FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316397925> ?p ?o ?g. }

• W2316397925 endingPage "10810" @default.
• W2316397925 startingPage "10804" @default.
• W2316397925 abstract "Diazeniumdiolates that have the structure RHN-N(O)═NOR' are of interest as prodrug (caged) forms of the bioeffectors nitric oxide (NO) and nitroxyl (HNO). Previous work has focused on examples possessing α-branched R groups, with isopropylamine (IPA)/NO (R = isopropyl) being the smallest examined to date. To probe the effect of minimizing the alkyl-group size on the chemistry of IPA/NO, we prepared the corresponding methylamine derivative as a sodium salt that was highly unstable but could be trapped in very low overall yield as the stable O(2)-benzyl derivative. To prepare enough for efficient characterization, we devised an alternate synthesis involving a novel N-dealkylation route. CH(3)HN-N(O)═NOBn, synthesized in high yield and crystallized as the Z isomer as determined by X-ray crystallography, was observed to exist as a 11:1 mixture of two isomeric forms in dynamic equilibrium in solution. Similar results were seen for the O(2)-ethyl derivative, whose two equilibrium constituents were partially separated by HPLC to reveal essentially identical UV and mass spectra, indicating them to be Z and E isomers of CH(3)HN-N(O)═NOEt. The results could lead the way to a fuller understanding of the chemistry of the acyclic (E)-diazeniumdiolates." @default.
• W2316397925 created "2016-06-24" @default.
• W2316397925 creator A5030863493 @default.
• W2316397925 creator A5040241398 @default.
• W2316397925 creator A5069348197 @default.
• W2316397925 creator A5076715400 @default.
• W2316397925 creator A5078389294 @default.
• W2316397925 creator A5083878721 @default.
• W2316397925 date "2012-11-20" @default.
• W2316397925 modified "2023-09-25" @default.
• W2316397925 title "O2-Functionalized Methylamine Diazeniumdiolates: Evidence for E ⇄ Z Equilibration in an Acyclic System" @default.
• W2316397925 cites W1488020481 @default.
• W2316397925 cites W1512538844 @default.
• W2316397925 cites W1968578286 @default.
• W2316397925 cites W1973082528 @default.
• W2316397925 cites W1993482433 @default.
• W2316397925 cites W1993601025 @default.
• W2316397925 cites W1996254150 @default.
• W2316397925 cites W2000241647 @default.
• W2316397925 cites W2004325558 @default.
• W2316397925 cites W2008139703 @default.
• W2316397925 cites W2011083094 @default.
• W2316397925 cites W2032578248 @default.
• W2316397925 cites W2043286086 @default.
• W2316397925 cites W2045168703 @default.
• W2316397925 cites W2047504478 @default.
• W2316397925 cites W2051378307 @default.
• W2316397925 cites W2066837478 @default.
• W2316397925 cites W2068751000 @default.
• W2316397925 cites W2074920875 @default.
• W2316397925 cites W2085108974 @default.
• W2316397925 cites W2085555295 @default.
• W2316397925 cites W2088151161 @default.
• W2316397925 cites W2088456044 @default.
• W2316397925 cites W2093903751 @default.
• W2316397925 cites W2135822356 @default.
• W2316397925 cites W2152558346 @default.
• W2316397925 cites W2319319929 @default.
• W2316397925 doi "https://doi.org/10.1021/jo3020837" @default.
• W2316397925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7243909" @default.
• W2316397925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23137026" @default.
• W2316397925 hasPublicationYear "2012" @default.
• W2316397925 type Work @default.
• W2316397925 sameAs 2316397925 @default.
• W2316397925 citedByCount "9" @default.
• W2316397925 countsByYear W23163979252013 @default.
• W2316397925 countsByYear W23163979252014 @default.
• W2316397925 countsByYear W23163979252015 @default.
• W2316397925 countsByYear W23163979252016 @default.
• W2316397925 countsByYear W23163979252017 @default.
• W2316397925 countsByYear W23163979252018 @default.
• W2316397925 crossrefType "journal-article" @default.
• W2316397925 hasAuthorship W2316397925A5030863493 @default.
• W2316397925 hasAuthorship W2316397925A5040241398 @default.
• W2316397925 hasAuthorship W2316397925A5069348197 @default.
• W2316397925 hasAuthorship W2316397925A5076715400 @default.
• W2316397925 hasAuthorship W2316397925A5078389294 @default.
• W2316397925 hasAuthorship W2316397925A5083878721 @default.
• W2316397925 hasBestOaLocation W23163979252 @default.
• W2316397925 hasConcept C104264131 @default.
• W2316397925 hasConcept C106159729 @default.
• W2316397925 hasConcept C111771559 @default.
• W2316397925 hasConcept C134121241 @default.
• W2316397925 hasConcept C155647269 @default.
• W2316397925 hasConcept C161790260 @default.
• W2316397925 hasConcept C162324750 @default.
• W2316397925 hasConcept C164361826 @default.
• W2316397925 hasConcept C178790620 @default.
• W2316397925 hasConcept C179104552 @default.
• W2316397925 hasConcept C185592680 @default.
• W2316397925 hasConcept C191897082 @default.
• W2316397925 hasConcept C192562407 @default.
• W2316397925 hasConcept C2776142628 @default.
• W2316397925 hasConcept C2778969155 @default.
• W2316397925 hasConcept C2780263894 @default.
• W2316397925 hasConcept C2781206959 @default.
• W2316397925 hasConcept C2992472348 @default.
• W2316397925 hasConcept C71240020 @default.
• W2316397925 hasConceptScore W2316397925C104264131 @default.
• W2316397925 hasConceptScore W2316397925C106159729 @default.
• W2316397925 hasConceptScore W2316397925C111771559 @default.
• W2316397925 hasConceptScore W2316397925C134121241 @default.
• W2316397925 hasConceptScore W2316397925C155647269 @default.
• W2316397925 hasConceptScore W2316397925C161790260 @default.
• W2316397925 hasConceptScore W2316397925C162324750 @default.
• W2316397925 hasConceptScore W2316397925C164361826 @default.
• W2316397925 hasConceptScore W2316397925C178790620 @default.
• W2316397925 hasConceptScore W2316397925C179104552 @default.
• W2316397925 hasConceptScore W2316397925C185592680 @default.
• W2316397925 hasConceptScore W2316397925C191897082 @default.
• W2316397925 hasConceptScore W2316397925C192562407 @default.
• W2316397925 hasConceptScore W2316397925C2776142628 @default.
• W2316397925 hasConceptScore W2316397925C2778969155 @default.
• W2316397925 hasConceptScore W2316397925C2780263894 @default.
• W2316397925 hasConceptScore W2316397925C2781206959 @default.
• W2316397925 hasConceptScore W2316397925C2992472348 @default.
• W2316397925 hasConceptScore W2316397925C71240020 @default.
• W2316397925 hasIssue "23" @default.

• next