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- W2316402038 endingPage "23" @default.
- W2316402038 startingPage "1" @default.
- W2316402038 abstract "Liquid chromatography with single columns often does not succeed in the analysis of complex samples, in terms of resolution and analysis time. A relatively simple solution to enhance chromatographic resolution is the modulation of the stationary phase through the serial coupling of columns. This can be implemented with any type of column using compatible elution conditions and conventional instruments. This review describes the key features of column coupling and published procedures, where two or more columns were coupled in series to solve separation problems. In all reports, the authors could not resolve their samples with single columns, whereas significant enhancement in chromatographic performance was obtained when the columns were combined. Particularly interesting is the reduction in the analysis time in the isocratic mode, which alleviates the “general elution problem” of liquid chromatography, and may represent a stimulus for the proposal of new procedures, especially in combination with mass spectrometric, electrochemical and refractometric detection. Developments proposed to make the serial coupling of columns useful in routine and research laboratories are outlined, including optimisation strategies that facilitate the selection of the appropriate column combination and elution conditions (solvent content, flow rate or temperature) in both isocratic and gradient modes. The availability of zero dead volume couplers, able to connect standard columns, and the commercialisation of short columns with multiple lengths, have expanded the possibilities of success." @default.
- W2316402038 created "2016-06-24" @default.
- W2316402038 creator A5034828250 @default.
- W2316402038 creator A5038364672 @default.
- W2316402038 creator A5047722307 @default.
- W2316402038 creator A5053347505 @default.
- W2316402038 date "2016-06-01" @default.
- W2316402038 modified "2023-10-10" @default.
- W2316402038 title "Stationary phase modulation in liquid chromatography through the serial coupling of columns: A review" @default.
- W2316402038 cites W1501230833 @default.
- W2316402038 cites W1522833579 @default.
- W2316402038 cites W1557461046 @default.
- W2316402038 cites W1809364162 @default.
- W2316402038 cites W1961924463 @default.
- W2316402038 cites W1963962600 @default.
- W2316402038 cites W1966191999 @default.
- W2316402038 cites W1968646452 @default.
- W2316402038 cites W1968777632 @default.
- W2316402038 cites W1969916544 @default.
- W2316402038 cites W1970054715 @default.
- W2316402038 cites W1971134396 @default.
- W2316402038 cites W1971704874 @default.
- W2316402038 cites W1977493501 @default.
- W2316402038 cites W1977981145 @default.
- W2316402038 cites W1983556100 @default.
- W2316402038 cites W1983593215 @default.
- W2316402038 cites W1984578834 @default.
- W2316402038 cites W1987142394 @default.
- W2316402038 cites W1987708499 @default.
- W2316402038 cites W1987939257 @default.
- W2316402038 cites W1988623140 @default.
- W2316402038 cites W1991746363 @default.
- W2316402038 cites W2005022806 @default.
- W2316402038 cites W2007736346 @default.
- W2316402038 cites W2008835788 @default.
- W2316402038 cites W2008840494 @default.
- W2316402038 cites W2011659600 @default.
- W2316402038 cites W2015030176 @default.
- W2316402038 cites W2015466408 @default.
- W2316402038 cites W2016415565 @default.
- W2316402038 cites W2018804433 @default.
- W2316402038 cites W2019313964 @default.
- W2316402038 cites W2019488813 @default.
- W2316402038 cites W2026933075 @default.
- W2316402038 cites W2029895708 @default.
- W2316402038 cites W2032411444 @default.
- W2316402038 cites W2032873096 @default.
- W2316402038 cites W2033920475 @default.
- W2316402038 cites W2034958523 @default.
- W2316402038 cites W2036615855 @default.
- W2316402038 cites W2039048094 @default.
- W2316402038 cites W2045392883 @default.
- W2316402038 cites W2046752939 @default.
- W2316402038 cites W2047524855 @default.
- W2316402038 cites W2049596715 @default.
- W2316402038 cites W2052210288 @default.
- W2316402038 cites W2052839497 @default.
- W2316402038 cites W2057823493 @default.
- W2316402038 cites W2057974250 @default.
- W2316402038 cites W2059021082 @default.
- W2316402038 cites W2059788230 @default.
- W2316402038 cites W2060171650 @default.
- W2316402038 cites W2060182421 @default.
- W2316402038 cites W2061067338 @default.
- W2316402038 cites W2062179314 @default.
- W2316402038 cites W2068225561 @default.
- W2316402038 cites W2072175913 @default.
- W2316402038 cites W2072340658 @default.
- W2316402038 cites W2073541141 @default.
- W2316402038 cites W2075619260 @default.
- W2316402038 cites W2076266000 @default.
- W2316402038 cites W2076288055 @default.
- W2316402038 cites W2077208183 @default.
- W2316402038 cites W2079344043 @default.
- W2316402038 cites W2083094358 @default.
- W2316402038 cites W2087600316 @default.
- W2316402038 cites W2089687844 @default.
- W2316402038 cites W2090111710 @default.
- W2316402038 cites W2091592855 @default.
- W2316402038 cites W2092128755 @default.
- W2316402038 cites W2092228142 @default.
- W2316402038 cites W2092285118 @default.
- W2316402038 cites W2092292694 @default.
- W2316402038 cites W2093107063 @default.
- W2316402038 cites W2107743519 @default.
- W2316402038 cites W2118421249 @default.
- W2316402038 cites W2125840006 @default.
- W2316402038 cites W2133387602 @default.
- W2316402038 cites W2147409546 @default.
- W2316402038 cites W2147595314 @default.
- W2316402038 cites W2157492730 @default.
- W2316402038 cites W2164542685 @default.
- W2316402038 cites W2165714839 @default.
- W2316402038 cites W2169652569 @default.
- W2316402038 cites W2170954979 @default.
- W2316402038 cites W2318630629 @default.
- W2316402038 cites W2326727681 @default.
- W2316402038 cites W2767335610 @default.