FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316407639> ?p ?o ?g. }

• W2316407639 endingPage "163" @default.
• W2316407639 startingPage "159" @default.
• W2316407639 abstract "Purpose: Clozapine is an atypical neuroleptic agent, effective in treating drug-resistant schizophrenia. The aim of this work was to investigate overall sleep architecture and sleep spindle morphology characteristics, before and after combination treatment with clozapine, in patients with drug-resistant schizophrenia who underwent polysomnography. Methods: Standard polysomnographic techniques were used. To quantify the sleep spindle morphology, a modeling technique was used that quantifies time-varying patterns in both the spindle envelope and the intraspindle frequency. Results: After combination treatment with clozapine, the patients showed clinical improvement. In addition, their overall sleep architecture and, more importantly, parameters that quantify the time-varying sleep spindle morphology were affected. Specifically, the results showed increased stage 2 sleep, reduced slow-wave sleep, increased rapid eye movement sleep, increased total sleep time, decreased wake time after sleep onset, as well as effects on spindle amplitude and intraspindle frequency parameters. However, the above changes in overall sleep architecture were statistically nonsignificant trends. Conclusions: The findings concerning statistically significant effects on spindle amplitude and intraspindle frequency parameters may imply changes in cortical sleep EEG generation mechanisms, as well as changes in thalamic pacing mechanisms or in thalamo–cortical network dynamics involved in sleep EEG generation, as a result of combination treatment with clozapine. Significance: Sleep spindle parameters may serve as metrics for the eventual development of effective EEG biomarkers to investigate treatment effects and pathophysiological mechanisms in schizophrenia." @default.
• W2316407639 created "2016-06-24" @default.
• W2316407639 creator A5027864974 @default.
• W2316407639 creator A5036767968 @default.
• W2316407639 creator A5037840674 @default.
• W2316407639 creator A5055786582 @default.
• W2316407639 creator A5058936518 @default.
• W2316407639 creator A5064915306 @default.
• W2316407639 creator A5073439420 @default.
• W2316407639 date "2015-04-01" @default.
• W2316407639 modified "2023-09-26" @default.
• W2316407639 title "Sleep EEG and Spindle Characteristics After Combination Treatment With Clozapine in Drug-Resistant Schizophrenia" @default.
• W2316407639 cites W1972462094 @default.
• W2316407639 cites W1979179687 @default.
• W2316407639 cites W1989177807 @default.
• W2316407639 cites W2005457043 @default.
• W2316407639 cites W2029430017 @default.
• W2316407639 cites W2032834873 @default.
• W2316407639 cites W2042317394 @default.
• W2316407639 cites W2047550690 @default.
• W2316407639 cites W2049396870 @default.
• W2316407639 cites W2063783661 @default.
• W2316407639 cites W2073797983 @default.
• W2316407639 cites W2077633827 @default.
• W2316407639 cites W2086630321 @default.
• W2316407639 cites W2086792305 @default.
• W2316407639 cites W2087505840 @default.
• W2316407639 cites W2122197304 @default.
• W2316407639 cites W2123391170 @default.
• W2316407639 cites W2140606211 @default.
• W2316407639 cites W2140802690 @default.
• W2316407639 cites W2142670205 @default.
• W2316407639 doi "https://doi.org/10.1097/wnp.0000000000000145" @default.
• W2316407639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25350635" @default.
• W2316407639 hasPublicationYear "2015" @default.
• W2316407639 type Work @default.
• W2316407639 sameAs 2316407639 @default.
• W2316407639 citedByCount "9" @default.
• W2316407639 countsByYear W23164076392016 @default.
• W2316407639 countsByYear W23164076392017 @default.
• W2316407639 countsByYear W23164076392019 @default.
• W2316407639 countsByYear W23164076392020 @default.
• W2316407639 countsByYear W23164076392022 @default.
• W2316407639 countsByYear W23164076392023 @default.
• W2316407639 crossrefType "journal-article" @default.
• W2316407639 hasAuthorship W2316407639A5027864974 @default.
• W2316407639 hasAuthorship W2316407639A5036767968 @default.
• W2316407639 hasAuthorship W2316407639A5037840674 @default.
• W2316407639 hasAuthorship W2316407639A5055786582 @default.
• W2316407639 hasAuthorship W2316407639A5058936518 @default.
• W2316407639 hasAuthorship W2316407639A5064915306 @default.
• W2316407639 hasAuthorship W2316407639A5073439420 @default.
• W2316407639 hasConcept C110539466 @default.
• W2316407639 hasConcept C111919701 @default.
• W2316407639 hasConcept C118552586 @default.
• W2316407639 hasConcept C143647101 @default.
• W2316407639 hasConcept C15744967 @default.
• W2316407639 hasConcept C169760540 @default.
• W2316407639 hasConcept C2775841894 @default.
• W2316407639 hasConcept C2776412080 @default.
• W2316407639 hasConcept C2778205975 @default.
• W2316407639 hasConcept C2780864610 @default.
• W2316407639 hasConcept C41008148 @default.
• W2316407639 hasConcept C42219234 @default.
• W2316407639 hasConcept C522805319 @default.
• W2316407639 hasConcept C548259974 @default.
• W2316407639 hasConcept C71924100 @default.
• W2316407639 hasConceptScore W2316407639C110539466 @default.
• W2316407639 hasConceptScore W2316407639C111919701 @default.
• W2316407639 hasConceptScore W2316407639C118552586 @default.
• W2316407639 hasConceptScore W2316407639C143647101 @default.
• W2316407639 hasConceptScore W2316407639C15744967 @default.
• W2316407639 hasConceptScore W2316407639C169760540 @default.
• W2316407639 hasConceptScore W2316407639C2775841894 @default.
• W2316407639 hasConceptScore W2316407639C2776412080 @default.
• W2316407639 hasConceptScore W2316407639C2778205975 @default.
• W2316407639 hasConceptScore W2316407639C2780864610 @default.
• W2316407639 hasConceptScore W2316407639C41008148 @default.
• W2316407639 hasConceptScore W2316407639C42219234 @default.
• W2316407639 hasConceptScore W2316407639C522805319 @default.
• W2316407639 hasConceptScore W2316407639C548259974 @default.
• W2316407639 hasConceptScore W2316407639C71924100 @default.
• W2316407639 hasIssue "2" @default.
• W2316407639 hasLocation W23164076391 @default.
• W2316407639 hasLocation W23164076392 @default.
• W2316407639 hasOpenAccess W2316407639 @default.
• W2316407639 hasPrimaryLocation W23164076391 @default.
• W2316407639 hasRelatedWork W1993349533 @default.
• W2316407639 hasRelatedWork W2013283479 @default.
• W2316407639 hasRelatedWork W2114603675 @default.
• W2316407639 hasRelatedWork W2124599396 @default.
• W2316407639 hasRelatedWork W2311117709 @default.
• W2316407639 hasRelatedWork W2316407639 @default.
• W2316407639 hasRelatedWork W2319810220 @default.
• W2316407639 hasRelatedWork W2803642516 @default.
• W2316407639 hasRelatedWork W3001920123 @default.
• W2316407639 hasRelatedWork W41640785 @default.
• W2316407639 hasVolume "32" @default.

• next