Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316438863> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2316438863 endingPage "24" @default.
- W2316438863 startingPage "15" @default.
- W2316438863 abstract "Telomerase is an essential enzyme for maintaining the telomeres of chromosomes and thereby enhancing the sustained replication of cells. Because atherosclerosis and restenosis are characterized by cellular proliferation, we determined whether telomerase enzyme activity was present in coronary artery tissue from 23 patients undergoing directional coronary atherectomy. Telomerase activity was determined from detergent lysates of the atherectomy tissue using an enzyme-linked immunoadsorbent assay (ELISA)-based modification of the Telomere Repeat Amplification Protocol. The presence of telomerase activity was correlated with the occurrence of coronary artery restenosis. Eight of the 23 samples (35%) were positive for telomerase. Seventeen of the 23 patients had adequate clinical follow-up to judge restenosis status. Of these, 7 had restenosis and 5 of these 7 had detectable telomerase. Of the 10 patients without restenosis, 8 were telomerase negative (p≤ 0.05). We have shown, for the first time, that telomerase is found in 35% of atherosclerotic tissues. There was a strong trend toward an association between telomerase presence and restenosis in patients for whom follow-up data were available. The presence of telomerase in atherosclerotic tissue may enable a robust, sustained cellular proliferation in response to vascular injury that culminates in restenosis." @default.
- W2316438863 created "2016-06-24" @default.
- W2316438863 creator A5010984764 @default.
- W2316438863 creator A5015612883 @default.
- W2316438863 creator A5023351793 @default.
- W2316438863 creator A5041348555 @default.
- W2316438863 creator A5090186707 @default.
- W2316438863 date "2000-01-01" @default.
- W2316438863 modified "2023-09-25" @default.
- W2316438863 title "Prevalence of Telomerase in Coronary Artery Atherosclerosis" @default.
- W2316438863 cites W1600373583 @default.
- W2316438863 cites W1996593524 @default.
- W2316438863 cites W2004314923 @default.
- W2316438863 cites W2018089879 @default.
- W2316438863 cites W2019961938 @default.
- W2316438863 cites W2022893313 @default.
- W2316438863 cites W2049462421 @default.
- W2316438863 cites W2052910631 @default.
- W2316438863 cites W2058773932 @default.
- W2316438863 cites W2062395030 @default.
- W2316438863 cites W2076825355 @default.
- W2316438863 cites W2100550233 @default.
- W2316438863 cites W2104104049 @default.
- W2316438863 cites W2107392339 @default.
- W2316438863 cites W2108482850 @default.
- W2316438863 cites W2143063758 @default.
- W2316438863 cites W2157050965 @default.
- W2316438863 cites W2067688851 @default.
- W2316438863 doi "https://doi.org/10.1089/rej.1.2000.3.15" @default.
- W2316438863 hasPublicationYear "2000" @default.
- W2316438863 type Work @default.
- W2316438863 sameAs 2316438863 @default.
- W2316438863 citedByCount "5" @default.
- W2316438863 countsByYear W23164388632015 @default.
- W2316438863 crossrefType "journal-article" @default.
- W2316438863 hasAuthorship W2316438863A5010984764 @default.
- W2316438863 hasAuthorship W2316438863A5015612883 @default.
- W2316438863 hasAuthorship W2316438863A5023351793 @default.
- W2316438863 hasAuthorship W2316438863A5041348555 @default.
- W2316438863 hasAuthorship W2316438863A5090186707 @default.
- W2316438863 hasConcept C104317684 @default.
- W2316438863 hasConcept C126322002 @default.
- W2316438863 hasConcept C164705383 @default.
- W2316438863 hasConcept C177336024 @default.
- W2316438863 hasConcept C2776820930 @default.
- W2316438863 hasConcept C2777209855 @default.
- W2316438863 hasConcept C2778283817 @default.
- W2316438863 hasConcept C2778583881 @default.
- W2316438863 hasConcept C2778742706 @default.
- W2316438863 hasConcept C502942594 @default.
- W2316438863 hasConcept C54355233 @default.
- W2316438863 hasConcept C552990157 @default.
- W2316438863 hasConcept C71924100 @default.
- W2316438863 hasConcept C86803240 @default.
- W2316438863 hasConcept C94581717 @default.
- W2316438863 hasConceptScore W2316438863C104317684 @default.
- W2316438863 hasConceptScore W2316438863C126322002 @default.
- W2316438863 hasConceptScore W2316438863C164705383 @default.
- W2316438863 hasConceptScore W2316438863C177336024 @default.
- W2316438863 hasConceptScore W2316438863C2776820930 @default.
- W2316438863 hasConceptScore W2316438863C2777209855 @default.
- W2316438863 hasConceptScore W2316438863C2778283817 @default.
- W2316438863 hasConceptScore W2316438863C2778583881 @default.
- W2316438863 hasConceptScore W2316438863C2778742706 @default.
- W2316438863 hasConceptScore W2316438863C502942594 @default.
- W2316438863 hasConceptScore W2316438863C54355233 @default.
- W2316438863 hasConceptScore W2316438863C552990157 @default.
- W2316438863 hasConceptScore W2316438863C71924100 @default.
- W2316438863 hasConceptScore W2316438863C86803240 @default.
- W2316438863 hasConceptScore W2316438863C94581717 @default.
- W2316438863 hasIssue "1" @default.
- W2316438863 hasLocation W23164388631 @default.
- W2316438863 hasOpenAccess W2316438863 @default.
- W2316438863 hasPrimaryLocation W23164388631 @default.
- W2316438863 hasRelatedWork W1986135504 @default.
- W2316438863 hasRelatedWork W2091699981 @default.
- W2316438863 hasRelatedWork W2131014183 @default.
- W2316438863 hasRelatedWork W2316438863 @default.
- W2316438863 hasRelatedWork W2424105038 @default.
- W2316438863 hasRelatedWork W2906719431 @default.
- W2316438863 hasRelatedWork W2980841471 @default.
- W2316438863 hasRelatedWork W3111515855 @default.
- W2316438863 hasRelatedWork W3130033876 @default.
- W2316438863 hasRelatedWork W4286214341 @default.
- W2316438863 hasVolume "3" @default.
- W2316438863 isParatext "false" @default.
- W2316438863 isRetracted "false" @default.
- W2316438863 magId "2316438863" @default.
- W2316438863 workType "article" @default.