Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316449713> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2316449713 abstract "Objective: The accurate evaluation of the extent of residual disease after neoadjuvant chemotherapy (NAC) for breast cancer appears essential for successful clinical outcomes. However, there are limited date about the success of achieving negative margins in breast conservation therapy. Recently, we have developed virtual MRI sonography with magnetic navigation (real-time virtual sonography; RVS). RVS can overlay high-resolution structural image taken by sonography with functional image reflecting vascular permeability taken by MRI of the same site in real time. The objective of our study was to determine the relative accuracy of RVS in detecting residual tumors after NAC.Materials and Methods: Between April 2007 and May 2009, 96 breast conservation therapy were performed for invasive ductal carcinoma at our hospital. Fourteen patients with stage IIA-IIIB palpable invasive ductal carcinoma were enrolled in a study investigating the effects of NAC on tumor imaging. All patients underwent mammography, sonography, MRI, and RVS before and after NAC. MRI was performed with a 1.5-T scanner in the supine position using a flexible body surface coil to achieve the same position as that used in sonography. Based on MRI results, the absence or presence of residual tumors was used to classify treatment response into a clinically complete response (cCR) or non-cCR, respectively. Nine patients received lumpectomy, and 5 received mastectomy. The surgical resection area was determined by RVS. Detection rate was determined for residual tumors with or without RVS. The pathologically complete response (pCR) was defined as no invasive carcinoma.Results: All index tumors were detected by sonography and MRI before NAC. After NAC, a cCR was seen in 5 (5 of 14, 36%) patients. MRI correctly diagnosed pCR in 4 (4 of 5, 80%) patients. Detection rate for residual tumors was 9% (1 of 11) for mammography, 33% (3 of 9) for sonography alone, 78% (7 of 9) for MRI, and 89% (8 of 9) for RVS. It was noteworthy that 5 (5 of 5, 100%) cases with cCR were accurately localized onto the body surface with supplementation using RVS combined with pre- and post-NAC imaging while we were checking sonography. Although surgical excision was incomplete in 5 (5 of 9, 56%) patients, all positive surgical margins were ductal carcinoma in situ.Conclusions: By using RVS, two different forms of diagnostic imaging can be integrated in real time and thereby complement each other. The present results suggest that RVS is a useful imaging technique for detecting residual tumors that have been associated with local recurrence after NAC. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5024." @default.
- W2316449713 created "2016-06-24" @default.
- W2316449713 creator A5016171700 @default.
- W2316449713 creator A5032295552 @default.
- W2316449713 creator A5034705987 @default.
- W2316449713 creator A5039588134 @default.
- W2316449713 creator A5042998334 @default.
- W2316449713 creator A5059199772 @default.
- W2316449713 creator A5061945229 @default.
- W2316449713 creator A5064636550 @default.
- W2316449713 creator A5064838609 @default.
- W2316449713 date "2009-12-15" @default.
- W2316449713 modified "2023-09-27" @default.
- W2316449713 title "Impact of Virtual MRI Sonography with Magnetic Navigation on Detecting Residual Tumors in Patients with Breast Cancer Who Undergo Neoadjuvant Chemotherapy; Initial Experience." @default.
- W2316449713 doi "https://doi.org/10.1158/0008-5472.sabcs-09-5024" @default.
- W2316449713 hasPublicationYear "2009" @default.
- W2316449713 type Work @default.
- W2316449713 sameAs 2316449713 @default.
- W2316449713 citedByCount "0" @default.
- W2316449713 crossrefType "proceedings-article" @default.
- W2316449713 hasAuthorship W2316449713A5016171700 @default.
- W2316449713 hasAuthorship W2316449713A5032295552 @default.
- W2316449713 hasAuthorship W2316449713A5034705987 @default.
- W2316449713 hasAuthorship W2316449713A5039588134 @default.
- W2316449713 hasAuthorship W2316449713A5042998334 @default.
- W2316449713 hasAuthorship W2316449713A5059199772 @default.
- W2316449713 hasAuthorship W2316449713A5061945229 @default.
- W2316449713 hasAuthorship W2316449713A5064636550 @default.
- W2316449713 hasAuthorship W2316449713A5064838609 @default.
- W2316449713 hasConcept C121608353 @default.
- W2316449713 hasConcept C126322002 @default.
- W2316449713 hasConcept C126838900 @default.
- W2316449713 hasConcept C143409427 @default.
- W2316449713 hasConcept C146357865 @default.
- W2316449713 hasConcept C151730666 @default.
- W2316449713 hasConcept C2776694085 @default.
- W2316449713 hasConcept C2777757722 @default.
- W2316449713 hasConcept C2779572924 @default.
- W2316449713 hasConcept C530470458 @default.
- W2316449713 hasConcept C71924100 @default.
- W2316449713 hasConcept C86803240 @default.
- W2316449713 hasConceptScore W2316449713C121608353 @default.
- W2316449713 hasConceptScore W2316449713C126322002 @default.
- W2316449713 hasConceptScore W2316449713C126838900 @default.
- W2316449713 hasConceptScore W2316449713C143409427 @default.
- W2316449713 hasConceptScore W2316449713C146357865 @default.
- W2316449713 hasConceptScore W2316449713C151730666 @default.
- W2316449713 hasConceptScore W2316449713C2776694085 @default.
- W2316449713 hasConceptScore W2316449713C2777757722 @default.
- W2316449713 hasConceptScore W2316449713C2779572924 @default.
- W2316449713 hasConceptScore W2316449713C530470458 @default.
- W2316449713 hasConceptScore W2316449713C71924100 @default.
- W2316449713 hasConceptScore W2316449713C86803240 @default.
- W2316449713 hasLocation W23164497131 @default.
- W2316449713 hasOpenAccess W2316449713 @default.
- W2316449713 hasPrimaryLocation W23164497131 @default.
- W2316449713 hasRelatedWork W1990185598 @default.
- W2316449713 hasRelatedWork W2011241834 @default.
- W2316449713 hasRelatedWork W2055831487 @default.
- W2316449713 hasRelatedWork W2072383130 @default.
- W2316449713 hasRelatedWork W2074705244 @default.
- W2316449713 hasRelatedWork W2079445897 @default.
- W2316449713 hasRelatedWork W2104897925 @default.
- W2316449713 hasRelatedWork W2128734851 @default.
- W2316449713 hasRelatedWork W2317763280 @default.
- W2316449713 hasRelatedWork W2330299754 @default.
- W2316449713 hasRelatedWork W2338011289 @default.
- W2316449713 hasRelatedWork W2797282265 @default.
- W2316449713 hasRelatedWork W2888672322 @default.
- W2316449713 hasRelatedWork W2926443120 @default.
- W2316449713 hasRelatedWork W3013807449 @default.
- W2316449713 hasRelatedWork W3016694714 @default.
- W2316449713 hasRelatedWork W3025229436 @default.
- W2316449713 hasRelatedWork W3160825506 @default.
- W2316449713 hasRelatedWork W3168418507 @default.
- W2316449713 hasRelatedWork W3210574527 @default.
- W2316449713 isParatext "false" @default.
- W2316449713 isRetracted "false" @default.
- W2316449713 magId "2316449713" @default.
- W2316449713 workType "article" @default.