Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316456224> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2316456224 endingPage "946" @default.
- W2316456224 startingPage "943" @default.
- W2316456224 abstract "The acquisition of resistance to nucleoside reverse transcriptase inhibitors (NRTIs) can be mediated by amino acid changes at the dNTP binding site that affect the catalytic efficiency of nucleotide analogue incorporation, or by mutations that, in the presence of a pyrophosphate donor, facilitate excision of 3'-terminal chain-terminating inhibitors from blocked primers. These mutations, known as thymidine analogue resistance mutations (TAMs) are M41L, D67N, K70R, L210W, T215F/Y and K219E/Q. Recently published crystal structures of wild-type and TAM-containing HIV-1 reverse transcriptases bound to double-stranded DNA and the excision product, azidothymidine adenosine dinucleoside tetraphosphate have shed light into the molecular mechanism of excision." @default.
- W2316456224 created "2016-06-24" @default.
- W2316456224 creator A5061687469 @default.
- W2316456224 date "2011-01-01" @default.
- W2316456224 modified "2023-09-26" @default.
- W2316456224 title "A structural frame for understanding the role of thymidine analogue resistance mutations in resistance to zidovudine and other nucleoside analogues" @default.
- W2316456224 doi "https://doi.org/10.3851/imp1889" @default.
- W2316456224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22024508" @default.
- W2316456224 hasPublicationYear "2011" @default.
- W2316456224 type Work @default.
- W2316456224 sameAs 2316456224 @default.
- W2316456224 citedByCount "3" @default.
- W2316456224 countsByYear W23164562242017 @default.
- W2316456224 countsByYear W23164562242020 @default.
- W2316456224 countsByYear W23164562242021 @default.
- W2316456224 crossrefType "journal-article" @default.
- W2316456224 hasAuthorship W2316456224A5061687469 @default.
- W2316456224 hasConcept C104317684 @default.
- W2316456224 hasConcept C153574943 @default.
- W2316456224 hasConcept C153911025 @default.
- W2316456224 hasConcept C156719811 @default.
- W2316456224 hasConcept C159047783 @default.
- W2316456224 hasConcept C185592680 @default.
- W2316456224 hasConcept C2776543447 @default.
- W2316456224 hasConcept C2776991684 @default.
- W2316456224 hasConcept C2777108182 @default.
- W2316456224 hasConcept C2777333352 @default.
- W2316456224 hasConcept C2780216070 @default.
- W2316456224 hasConcept C2780727368 @default.
- W2316456224 hasConcept C2909970146 @default.
- W2316456224 hasConcept C3013748606 @default.
- W2316456224 hasConcept C49105822 @default.
- W2316456224 hasConcept C501734568 @default.
- W2316456224 hasConcept C512185932 @default.
- W2316456224 hasConcept C54355233 @default.
- W2316456224 hasConcept C552990157 @default.
- W2316456224 hasConcept C55493867 @default.
- W2316456224 hasConcept C67705224 @default.
- W2316456224 hasConcept C86803240 @default.
- W2316456224 hasConceptScore W2316456224C104317684 @default.
- W2316456224 hasConceptScore W2316456224C153574943 @default.
- W2316456224 hasConceptScore W2316456224C153911025 @default.
- W2316456224 hasConceptScore W2316456224C156719811 @default.
- W2316456224 hasConceptScore W2316456224C159047783 @default.
- W2316456224 hasConceptScore W2316456224C185592680 @default.
- W2316456224 hasConceptScore W2316456224C2776543447 @default.
- W2316456224 hasConceptScore W2316456224C2776991684 @default.
- W2316456224 hasConceptScore W2316456224C2777108182 @default.
- W2316456224 hasConceptScore W2316456224C2777333352 @default.
- W2316456224 hasConceptScore W2316456224C2780216070 @default.
- W2316456224 hasConceptScore W2316456224C2780727368 @default.
- W2316456224 hasConceptScore W2316456224C2909970146 @default.
- W2316456224 hasConceptScore W2316456224C3013748606 @default.
- W2316456224 hasConceptScore W2316456224C49105822 @default.
- W2316456224 hasConceptScore W2316456224C501734568 @default.
- W2316456224 hasConceptScore W2316456224C512185932 @default.
- W2316456224 hasConceptScore W2316456224C54355233 @default.
- W2316456224 hasConceptScore W2316456224C552990157 @default.
- W2316456224 hasConceptScore W2316456224C55493867 @default.
- W2316456224 hasConceptScore W2316456224C67705224 @default.
- W2316456224 hasConceptScore W2316456224C86803240 @default.
- W2316456224 hasIssue "7" @default.
- W2316456224 hasLocation W23164562241 @default.
- W2316456224 hasLocation W23164562242 @default.
- W2316456224 hasOpenAccess W2316456224 @default.
- W2316456224 hasPrimaryLocation W23164562241 @default.
- W2316456224 hasRelatedWork W1978176235 @default.
- W2316456224 hasRelatedWork W2002104731 @default.
- W2316456224 hasRelatedWork W2011144380 @default.
- W2316456224 hasRelatedWork W2017028114 @default.
- W2316456224 hasRelatedWork W2026564608 @default.
- W2316456224 hasRelatedWork W2045696382 @default.
- W2316456224 hasRelatedWork W2089353687 @default.
- W2316456224 hasRelatedWork W2109587611 @default.
- W2316456224 hasRelatedWork W2130241957 @default.
- W2316456224 hasRelatedWork W2147264814 @default.
- W2316456224 hasVolume "16" @default.
- W2316456224 isParatext "false" @default.
- W2316456224 isRetracted "false" @default.
- W2316456224 magId "2316456224" @default.
- W2316456224 workType "article" @default.