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- W2316457686 abstract "Novel boron-containing molecules prove effective killers of trypanosomes, the parasites that cause African trypanosomiasis, or sleeping sickness, according to Bakela Nare and Stephen Wring of Scynexis in Research Triangle Park, N.C., and their collaborators there, and at U.S. and Swiss universities as well as drug-development institutions in the United States and Switzerland. These oxaborole compounds, which belong to “the first new class of chemical showing activity in stage 2 African trypanosomiasis rodent models in a generation,” owe their effectiveness more to their pharmacokinetic tenacity for staying within the brain than to their direct potency against these parasites, Nare says. Details appear in the October 2010 Antimicrobial Agents and Chemotherapy (54:4379–4388)." @default.
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- W2316457686 date "2011-01-01" @default.
- W2316457686 modified "2023-09-25" @default.
- W2316457686 title "Boron-Containing Drug Candidates Effective vs. Sleeping Sickness Parasites" @default.
- W2316457686 doi "https://doi.org/10.1128/microbe.6.5.1" @default.
- W2316457686 hasPublicationYear "2011" @default.
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