FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316457796> ?p ?o ?g. }

• W2316457796 endingPage "A36" @default.
• W2316457796 startingPage "A36" @default.
• W2316457796 abstract "<h3>Introduction and Objectives</h3> Endothelial barrier dysfunction contributes to the systemic inflammatory response syndrome (SIRS) for which cardiac surgery necessitating cardiopulmonary bypass (snCPB) is a human model. A growing body of evidence suggests that the receptor for advanced glycation end products (RAGE) is also implicated in the pathogenesis of SIRS. While RAGE activation, in vitro, is known to decrease barrier function of cultured endothelial cells, the role of RAGE in regulating vascular permeability in patients undergoing snCPB is unknown. We hypothesised that plasma levels of markers of endothelial barrier dysfunction, syndecan-1, an endothelial glycocalyx component; and sFlt-1, a soluble form of the vascular endothelial cell growth factor (VEGF) receptor-1, will increase during snCPB and levels relate to patient outcome. <h3>Methods</h3> ELISA measurements/western blotting was used to determine syndecan-1 and sFlt-1 levels in pre-, intra- and post-snCPB plasma samples; for comparison, glypican-1, another glycocalyx component and Robo4, an endothelial barrier stabilising protein, were also measured. Clinical indices: age, nature of operation, CPB time, ischaemic time, intensive care unit (ICU)/ hospital length of stay (LOS) were collected from electronic databases. <h3>Results</h3> Syndecan-1 was significantly higher during CPB (77.17±39.72 ng/ml) compared with pre-snCPB levels (35.26±25.81 ng/ml, n=14, p<0.01). Plasma levels of sFLt-1 were significantly (p<0.001) higher during (10 000 pg/ml±3601, n=10) and post-snCPB (4282±3271 pg/ml) compared with preoperative levels (69.68±35.22 pg/ml). Preoperative plasma syndecan-1 correlated positively with ICU LOS (r²=0.486, p=0.006); whereas, intraoperative sFlt-1 correlated negatively with ICU LOS (r²=0.406, p=0.048). Intraoperative syndecan-1 levels positively associated with ischaemic time (r²=0.383, p=0.018) and plasma sRAGE levels (r²=389, p=0.040); postoperative syndecan-1 levels correlated with sRAGE (r²=0.790, p=0.0003). Glypican-1 and Robo4 were also detected in snCPB plasma samples. <h3>Conclusion</h3> Plasma levels of syndecan-1 and sFlt-1 were highest during snCPB. A positive association between preoperative syndecan-1 and ICU LOS is consistent with a relationship between endothelial barrier dysfunction and outcome. By contrast, higher intraoperative sFlt-1 correlating with shorter ICU LOS implied a protective role of sFlt-1. Associations between syndecan-1 and sRAGE suggest a link between RAGE and endothelial barrier dysfunction that merits further investigation; as do the novel findings that glypican-1 and Robo4 were detected in plasma of patients undergoing snCPB." @default.
• W2316457796 created "2016-06-24" @default.
• W2316457796 creator A5002020342 @default.
• W2316457796 creator A5056425064 @default.
• W2316457796 creator A5066395614 @default.
• W2316457796 creator A5081233294 @default.
• W2316457796 creator A5086294849 @default.
• W2316457796 date "2011-12-01" @default.
• W2316457796 modified "2023-09-27" @default.
• W2316457796 title "S74 Increased plasma levels of syndecan-1 and sFlt-1 during cardiopulmonary bypass surgery: associations with sRAGE" @default.
• W2316457796 doi "https://doi.org/10.1136/thoraxjnl-2011-201054b.74" @default.
• W2316457796 hasPublicationYear "2011" @default.
• W2316457796 type Work @default.
• W2316457796 sameAs 2316457796 @default.
• W2316457796 citedByCount "0" @default.
• W2316457796 crossrefType "journal-article" @default.
• W2316457796 hasAuthorship W2316457796A5002020342 @default.
• W2316457796 hasAuthorship W2316457796A5056425064 @default.
• W2316457796 hasAuthorship W2316457796A5066395614 @default.
• W2316457796 hasAuthorship W2316457796A5081233294 @default.
• W2316457796 hasAuthorship W2316457796A5086294849 @default.
• W2316457796 hasBestOaLocation W23164577961 @default.
• W2316457796 hasConcept C104317684 @default.
• W2316457796 hasConcept C126322002 @default.
• W2316457796 hasConcept C134018914 @default.
• W2316457796 hasConcept C147990577 @default.
• W2316457796 hasConcept C1491633281 @default.
• W2316457796 hasConcept C164705383 @default.
• W2316457796 hasConcept C167734588 @default.
• W2316457796 hasConcept C169760540 @default.
• W2316457796 hasConcept C170493617 @default.
• W2316457796 hasConcept C203014093 @default.
• W2316457796 hasConcept C2776246508 @default.
• W2316457796 hasConcept C2776992346 @default.
• W2316457796 hasConcept C2777025900 @default.
• W2316457796 hasConcept C2778857457 @default.
• W2316457796 hasConcept C2778881276 @default.
• W2316457796 hasConcept C2779094623 @default.
• W2316457796 hasConcept C2780098789 @default.
• W2316457796 hasConcept C2780972559 @default.
• W2316457796 hasConcept C54355233 @default.
• W2316457796 hasConcept C55493867 @default.
• W2316457796 hasConcept C65001120 @default.
• W2316457796 hasConcept C71924100 @default.
• W2316457796 hasConcept C85265743 @default.
• W2316457796 hasConcept C86803240 @default.
• W2316457796 hasConceptScore W2316457796C104317684 @default.
• W2316457796 hasConceptScore W2316457796C126322002 @default.
• W2316457796 hasConceptScore W2316457796C134018914 @default.
• W2316457796 hasConceptScore W2316457796C147990577 @default.
• W2316457796 hasConceptScore W2316457796C1491633281 @default.
• W2316457796 hasConceptScore W2316457796C164705383 @default.
• W2316457796 hasConceptScore W2316457796C167734588 @default.
• W2316457796 hasConceptScore W2316457796C169760540 @default.
• W2316457796 hasConceptScore W2316457796C170493617 @default.
• W2316457796 hasConceptScore W2316457796C203014093 @default.
• W2316457796 hasConceptScore W2316457796C2776246508 @default.
• W2316457796 hasConceptScore W2316457796C2776992346 @default.
• W2316457796 hasConceptScore W2316457796C2777025900 @default.
• W2316457796 hasConceptScore W2316457796C2778857457 @default.
• W2316457796 hasConceptScore W2316457796C2778881276 @default.
• W2316457796 hasConceptScore W2316457796C2779094623 @default.
• W2316457796 hasConceptScore W2316457796C2780098789 @default.
• W2316457796 hasConceptScore W2316457796C2780972559 @default.
• W2316457796 hasConceptScore W2316457796C54355233 @default.
• W2316457796 hasConceptScore W2316457796C55493867 @default.
• W2316457796 hasConceptScore W2316457796C65001120 @default.
• W2316457796 hasConceptScore W2316457796C71924100 @default.
• W2316457796 hasConceptScore W2316457796C85265743 @default.
• W2316457796 hasConceptScore W2316457796C86803240 @default.
• W2316457796 hasIssue "Suppl 4" @default.
• W2316457796 hasLocation W23164577961 @default.
• W2316457796 hasLocation W23164577962 @default.
• W2316457796 hasOpenAccess W2316457796 @default.
• W2316457796 hasPrimaryLocation W23164577961 @default.
• W2316457796 hasRelatedWork W151770906 @default.
• W2316457796 hasRelatedWork W1688216993 @default.
• W2316457796 hasRelatedWork W2040465332 @default.
• W2316457796 hasRelatedWork W2097873621 @default.
• W2316457796 hasRelatedWork W2313951464 @default.
• W2316457796 hasRelatedWork W2316457796 @default.
• W2316457796 hasRelatedWork W2809320056 @default.
• W2316457796 hasRelatedWork W2898508325 @default.
• W2316457796 hasRelatedWork W3161555936 @default.
• W2316457796 hasRelatedWork W3197306031 @default.
• W2316457796 hasVolume "66" @default.
• W2316457796 isParatext "false" @default.
• W2316457796 isRetracted "false" @default.
• W2316457796 magId "2316457796" @default.
• W2316457796 workType "article" @default.