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• W2316458411 abstract "Synthetic DNA molecules of 10-23 deoxyribozymes (Dz) are known to be efficient and site-specific agents for the RNA cleavage in a catalytic manner. To provide the penetration of Dz into cells, we have proposed the new delivery system for deoxyribozymes in the form of TiO2•PL-Dz nanocomposite. These nanocomposites consist of catalytically active Dz molecules noncovalently immobilized through the polylysine linker to TiO2 nanoparticles, which provide the penetration of Dz into cells. Deoxyribozymes in the prepared TiO2•PL-Dz nanocomposites were shown to retain their ability to cleave RNA targets albeit at a slower rate but with the same site-specificity and similar efficiency as free Dz. Unlike free Dz, the proposed TiO2•PL-Dz nanocomposites penetrate into cells without auxiliary actions. Keywords: Delivery, deoxyribozymes, immobilization, nanocomposites, TiO2 nanoparticles." @default.
• W2316458411 created "2016-06-24" @default.
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• W2316458411 date "2014-08-31" @default.
• W2316458411 modified "2023-10-03" @default.
• W2316458411 title "TiO₂&#126;Deoxyribozyme Nanocomposites as Delivery System and Efficient Site-Specific Agents for Cleavage of RNA Targets" @default.
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• W2316458411 doi "https://doi.org/10.2174/2210303104666140222002510" @default.
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