FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316480452> ?p ?o ?g. }

• W2316480452 endingPage "1972" @default.
• W2316480452 startingPage "1966" @default.
• W2316480452 abstract "The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g). Whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in renal, intestinal, and cerebral blood flow is not known.Soon after they were born, we randomly assigned 1202 infants with birth weights of 500 to 999 g (extremely low birth weight) to receive either indomethacin (0.1 mg per kilogram of body weight) or placebo intravenously once daily for three days. The primary outcome was a composite of death, cerebral palsy, cognitive delay, deafness, and blindness at a corrected age of 18 months. Secondary long-term outcomes were hydrocephalus necessitating the placement of a shunt, seizure disorder, and microcephaly within the same time frame. Secondary short-term outcomes were patent ductus arteriosus, pulmonary hemorrhage, chronic lung disease, ultrasonographic evidence of intracranial abnormalities, necrotizing enterocolitis, and retinopathy.Of the 574 infants with data on the primary outcome who were assigned to prophylaxis with indomethacin, 271 (47 percent) died or survived with impairments, as compared with 261 of the 569 infants (46 percent) assigned to placebo (odds ratio, 1.1; 95 percent confidence interval, 0.8 to 1.4; P=0.61). Indomethacin reduced the incidence of patent ductus arteriosus (24 percent vs. 50 percent in the placebo group; odds ratio, 0.3; P<0.001) and of severe periventricular and intraventricular hemorrhage (9 percent vs. 13 percent in the placebo group; odds ratio, 0.6; P=0.02). No other outcomes were altered by the prophylactic administration of indomethacin.In extremely-low-birth-weight infants, prophylaxis with indomethacin does not improve the rate of survival without neurosensory impairment at 18 months, despite the fact that it reduces the frequency of patent ductus arteriosus and severe periventricular and intraventricular hemorrhage." @default.
• W2316480452 created "2016-06-24" @default.
• W2316480452 creator A5004762558 @default.
• W2316480452 creator A5014623789 @default.
• W2316480452 creator A5021581303 @default.
• W2316480452 creator A5027862581 @default.
• W2316480452 creator A5031705633 @default.
• W2316480452 creator A5033715797 @default.
• W2316480452 creator A5041821959 @default.
• W2316480452 creator A5046655310 @default.
• W2316480452 creator A5049709255 @default.
• W2316480452 date "2001-06-28" @default.
• W2316480452 modified "2023-10-17" @default.
• W2316480452 title "Long-Term Effects of Indomethacin Prophylaxis in Extremely-Low-Birth-Weight Infants" @default.
• W2316480452 cites W1518272913 @default.
• W2316480452 cites W1559776460 @default.
• W2316480452 cites W1572297871 @default.
• W2316480452 cites W1999954941 @default.
• W2316480452 cites W2017766892 @default.
• W2316480452 cites W2020861220 @default.
• W2316480452 cites W2041241400 @default.
• W2316480452 cites W2046224781 @default.
• W2316480452 cites W2074928061 @default.
• W2316480452 cites W2112597409 @default.
• W2316480452 cites W2130048159 @default.
• W2316480452 cites W2143627246 @default.
• W2316480452 cites W2149974774 @default.
• W2316480452 cites W2156168620 @default.
• W2316480452 cites W2319887059 @default.
• W2316480452 cites W4205953961 @default.
• W2316480452 cites W4293177759 @default.
• W2316480452 doi "https://doi.org/10.1056/nejm200106283442602" @default.
• W2316480452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11430325" @default.
• W2316480452 hasPublicationYear "2001" @default.
• W2316480452 type Work @default.
• W2316480452 sameAs 2316480452 @default.
• W2316480452 citedByCount "643" @default.
• W2316480452 countsByYear W23164804522012 @default.
• W2316480452 countsByYear W23164804522013 @default.
• W2316480452 countsByYear W23164804522014 @default.
• W2316480452 countsByYear W23164804522015 @default.
• W2316480452 countsByYear W23164804522016 @default.
• W2316480452 countsByYear W23164804522017 @default.
• W2316480452 countsByYear W23164804522018 @default.
• W2316480452 countsByYear W23164804522019 @default.
• W2316480452 countsByYear W23164804522020 @default.
• W2316480452 countsByYear W23164804522021 @default.
• W2316480452 countsByYear W23164804522022 @default.
• W2316480452 countsByYear W23164804522023 @default.
• W2316480452 crossrefType "journal-article" @default.
• W2316480452 hasAuthorship W2316480452A5004762558 @default.
• W2316480452 hasAuthorship W2316480452A5014623789 @default.
• W2316480452 hasAuthorship W2316480452A5021581303 @default.
• W2316480452 hasAuthorship W2316480452A5027862581 @default.
• W2316480452 hasAuthorship W2316480452A5031705633 @default.
• W2316480452 hasAuthorship W2316480452A5033715797 @default.
• W2316480452 hasAuthorship W2316480452A5041821959 @default.
• W2316480452 hasAuthorship W2316480452A5046655310 @default.
• W2316480452 hasAuthorship W2316480452A5049709255 @default.
• W2316480452 hasBestOaLocation W23164804521 @default.
• W2316480452 hasConcept C126322002 @default.
• W2316480452 hasConcept C141071460 @default.
• W2316480452 hasConcept C142724271 @default.
• W2316480452 hasConcept C156957248 @default.
• W2316480452 hasConcept C187212893 @default.
• W2316480452 hasConcept C204787440 @default.
• W2316480452 hasConcept C27081682 @default.
• W2316480452 hasConcept C2777050789 @default.
• W2316480452 hasConcept C2777714996 @default.
• W2316480452 hasConcept C2778376644 @default.
• W2316480452 hasConcept C2778721537 @default.
• W2316480452 hasConcept C2779083892 @default.
• W2316480452 hasConcept C2779234561 @default.
• W2316480452 hasConcept C2779252433 @default.
• W2316480452 hasConcept C2779303187 @default.
• W2316480452 hasConcept C2779918416 @default.
• W2316480452 hasConcept C2781236024 @default.
• W2316480452 hasConcept C42219234 @default.
• W2316480452 hasConcept C54355233 @default.
• W2316480452 hasConcept C66322754 @default.
• W2316480452 hasConcept C71924100 @default.
• W2316480452 hasConcept C86803240 @default.
• W2316480452 hasConceptScore W2316480452C126322002 @default.
• W2316480452 hasConceptScore W2316480452C141071460 @default.
• W2316480452 hasConceptScore W2316480452C142724271 @default.
• W2316480452 hasConceptScore W2316480452C156957248 @default.
• W2316480452 hasConceptScore W2316480452C187212893 @default.
• W2316480452 hasConceptScore W2316480452C204787440 @default.
• W2316480452 hasConceptScore W2316480452C27081682 @default.
• W2316480452 hasConceptScore W2316480452C2777050789 @default.
• W2316480452 hasConceptScore W2316480452C2777714996 @default.
• W2316480452 hasConceptScore W2316480452C2778376644 @default.
• W2316480452 hasConceptScore W2316480452C2778721537 @default.
• W2316480452 hasConceptScore W2316480452C2779083892 @default.
• W2316480452 hasConceptScore W2316480452C2779234561 @default.
• W2316480452 hasConceptScore W2316480452C2779252433 @default.
• W2316480452 hasConceptScore W2316480452C2779303187 @default.
• W2316480452 hasConceptScore W2316480452C2779918416 @default.

• next