Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316489150> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2316489150 abstract "Lung cancer in never-smokers is increasingly recognized as distinct from that in ever-smokers owing to substantial differences in etiology, clinical characteristics, and prognosis. Therefore, we aimed to identify prognostic markers specific for lung cancer in never-smokers in a two-stage study. First, 11,930 single-nucleotide polymorphisms (SNPs) in 904 inflammation-related genes were genotyped, and their associations with overall survival in 411 never-smokers with lung cancer at The University of Texas MD Anderson Cancer Center were analyzed. Next, fast-track validation of the top 37 SNPs in 311 never-smokers with lung cancer at Mayo Clinic was performed. Three SNPs (interleukin 17 receptor A:rs879576, bone morphogenetic protein 8A:rs698141, and spleen tyrosine kinase:rs290229) were validated (p −5 [p=0.61, heterogeneity test]). We successfully validated a survival tree created in MD Anderson population based on gene-gene interactions in the Mayo Clinic population. This survival tree stratified patients into subsets with significantly different risks of death: patients at MD Anderson with the rs1056400_GG/rs698141_GA+AA genotype had a 2.32-fold higher risk of death (p=1.72 × 10 −5 ) and 9-month shorter median survival time (MST) (p=4.5 × 10 −4 , log-rank test) than did those with the rs1056400_GG/rs698141_GG or rs1056400_GA+AA genotype in the discovery phase. Also, the patients at Mayo Clinic with the former genotype had an approximately twofold higher risk of death (p=0.02) and a strikingly shorter (by 26 months) MST (p=0.029, log-rank test) than did those with the latter genotype in the validation phase. We evaluated these five SNPs in 996 ever-smokers and found no significant associations. To our knowledge, this is the first study to systematically evaluate the associations of genetic variations in major inflammation-related genes with outcome of lung cancer in never-smokers. It provides strong evidence that inflammation-related genetic variations can affect clinical outcomes in these patients, which may lead to significant biological insight into these outcomes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2929. doi:1538-7445.AM2012-2929" @default.
- W2316489150 created "2016-06-24" @default.
- W2316489150 creator A5012002845 @default.
- W2316489150 creator A5015664950 @default.
- W2316489150 creator A5027152610 @default.
- W2316489150 creator A5048865240 @default.
- W2316489150 creator A5050250764 @default.
- W2316489150 creator A5066957198 @default.
- W2316489150 creator A5069190968 @default.
- W2316489150 creator A5076900449 @default.
- W2316489150 creator A5082365305 @default.
- W2316489150 creator A5085188591 @default.
- W2316489150 creator A5086376470 @default.
- W2316489150 creator A5086664647 @default.
- W2316489150 date "2012-04-15" @default.
- W2316489150 modified "2023-09-27" @default.
- W2316489150 title "Abstract 2929: Predictors of survival in never-smokers with non-small cell lung cancer: A large-scale, two-phase genetic study" @default.
- W2316489150 doi "https://doi.org/10.1158/1538-7445.am2012-2929" @default.
- W2316489150 hasPublicationYear "2012" @default.
- W2316489150 type Work @default.
- W2316489150 sameAs 2316489150 @default.
- W2316489150 citedByCount "0" @default.
- W2316489150 crossrefType "proceedings-article" @default.
- W2316489150 hasAuthorship W2316489150A5012002845 @default.
- W2316489150 hasAuthorship W2316489150A5015664950 @default.
- W2316489150 hasAuthorship W2316489150A5027152610 @default.
- W2316489150 hasAuthorship W2316489150A5048865240 @default.
- W2316489150 hasAuthorship W2316489150A5050250764 @default.
- W2316489150 hasAuthorship W2316489150A5066957198 @default.
- W2316489150 hasAuthorship W2316489150A5069190968 @default.
- W2316489150 hasAuthorship W2316489150A5076900449 @default.
- W2316489150 hasAuthorship W2316489150A5082365305 @default.
- W2316489150 hasAuthorship W2316489150A5085188591 @default.
- W2316489150 hasAuthorship W2316489150A5086376470 @default.
- W2316489150 hasAuthorship W2316489150A5086664647 @default.
- W2316489150 hasConcept C104317684 @default.
- W2316489150 hasConcept C121608353 @default.
- W2316489150 hasConcept C126322002 @default.
- W2316489150 hasConcept C135763542 @default.
- W2316489150 hasConcept C143998085 @default.
- W2316489150 hasConcept C153209595 @default.
- W2316489150 hasConcept C2776256026 @default.
- W2316489150 hasConcept C2908647359 @default.
- W2316489150 hasConcept C54355233 @default.
- W2316489150 hasConcept C71924100 @default.
- W2316489150 hasConcept C86803240 @default.
- W2316489150 hasConcept C90924648 @default.
- W2316489150 hasConcept C99454951 @default.
- W2316489150 hasConceptScore W2316489150C104317684 @default.
- W2316489150 hasConceptScore W2316489150C121608353 @default.
- W2316489150 hasConceptScore W2316489150C126322002 @default.
- W2316489150 hasConceptScore W2316489150C135763542 @default.
- W2316489150 hasConceptScore W2316489150C143998085 @default.
- W2316489150 hasConceptScore W2316489150C153209595 @default.
- W2316489150 hasConceptScore W2316489150C2776256026 @default.
- W2316489150 hasConceptScore W2316489150C2908647359 @default.
- W2316489150 hasConceptScore W2316489150C54355233 @default.
- W2316489150 hasConceptScore W2316489150C71924100 @default.
- W2316489150 hasConceptScore W2316489150C86803240 @default.
- W2316489150 hasConceptScore W2316489150C90924648 @default.
- W2316489150 hasConceptScore W2316489150C99454951 @default.
- W2316489150 hasLocation W23164891501 @default.
- W2316489150 hasOpenAccess W2316489150 @default.
- W2316489150 hasPrimaryLocation W23164891501 @default.
- W2316489150 hasRelatedWork W1488560897 @default.
- W2316489150 hasRelatedWork W1942134178 @default.
- W2316489150 hasRelatedWork W1990762386 @default.
- W2316489150 hasRelatedWork W1994835054 @default.
- W2316489150 hasRelatedWork W2018205319 @default.
- W2316489150 hasRelatedWork W2039138172 @default.
- W2316489150 hasRelatedWork W2060803453 @default.
- W2316489150 hasRelatedWork W2122126348 @default.
- W2316489150 hasRelatedWork W2134899948 @default.
- W2316489150 hasRelatedWork W2166938282 @default.
- W2316489150 hasRelatedWork W2290724787 @default.
- W2316489150 hasRelatedWork W2319757861 @default.
- W2316489150 hasRelatedWork W2328098624 @default.
- W2316489150 hasRelatedWork W2333922595 @default.
- W2316489150 hasRelatedWork W2556093218 @default.
- W2316489150 hasRelatedWork W2590541679 @default.
- W2316489150 hasRelatedWork W2806113357 @default.
- W2316489150 hasRelatedWork W2891594515 @default.
- W2316489150 hasRelatedWork W2959950520 @default.
- W2316489150 hasRelatedWork W3006226013 @default.
- W2316489150 isParatext "false" @default.
- W2316489150 isRetracted "false" @default.
- W2316489150 magId "2316489150" @default.
- W2316489150 workType "article" @default.