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- W2316506314 abstract "Abnormal extracellular deposition of β-amyloid (Aβ) is thought to play a key role in the pathogenesis of Alzheimer’s disease (AD). Preventing Aβ-induced neurotoxicity has become a potential therapeutic approach to improve the onset and progression of AD. Here we report the synthesis of 1,1′-(biphenyl-4,4′-diyl)-bis(3-(dimethylamino)-propan-1-one) (BDBDP) and evaluate whether it protects PC12 cells from Aβ1–42-induced cytotoxicity in PC12 cells. Treating cells with Aβ1–42 significantly reduced cell viability and mitochondrial membrane potential while also significantly increasing apoptosis and production of reactive oxygen species (ROS). Pretreating the cells with BDBDP significantly ameloriated these Aβ1–42-induced effects. Futhermore, BDBDP strongly reduced pro-apoptotic signaling in response to ROS by reducing levels of activated caspase-3 and increasing the ratio of Bcl-2 to Bax. These findings provide evidence that BDBDP protects against Aβ1–42-induced neurotoxicity in PC12 cells by inhibiting oxidative stress and cell apoptosis." @default.
- W2316506314 created "2016-06-24" @default.
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- W2316506314 date "2013-12-26" @default.
- W2316506314 modified "2023-10-02" @default.
- W2316506314 title "Antioxidant and Antiapoptotic Effects of 1,1′-(Biphenyl-4,4′-diyl)-bis(3-(dimethylamino)-propan-1-one) on Protecting PC12 Cells from Aβ-Induced Injury" @default.
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- W2316506314 doi "https://doi.org/10.1021/mp400395g" @default.
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