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- W2316508053 abstract "Objective: An abnormal central nervous system excitability level was found in patients with migraine. Whether it is hyper- or hypo-excitable is still debated. This study aimed to compare the somatosensory high-frequency oscillations (HFOs), which reflected subcortical excitability (early phase) and intracortical inhibition (late phase), between patients with migraine and control subjects. Methods: HFOs were recorded from C3'-Fz, using a 500-1000 Hz frequency filter after stimulation at right median nerves at the wrists, and divided into early and late phases based on the N20 peak. Fifty-nine untreated patients (n=24 during ictal period; n=35, interictal) and 22 controls finished the study. Results: In early HFOs, patients both during ictal and interictal periods had higher maximal amplitudes ( p =0.039) and area-under-curve ( p =0.029) than those of the controls. Regarding the late HFOs, there were no significant differences among these groups. Conclusion: Our study suggests a hyper-excitable state in the subcortical regions in patients with migraine both during interictal and ictal periods." @default.
- W2316508053 created "2016-06-24" @default.
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- W2316508053 date "2011-03-01" @default.
- W2316508053 modified "2023-09-26" @default.
- W2316508053 title "Subcortical Hyperexcitability in Migraineurs: A High-Frequency Oscillation Study" @default.
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- W2316508053 doi "https://doi.org/10.1017/s0317167100011525" @default.
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