Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316532677> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2316532677 endingPage "35" @default.
- W2316532677 startingPage "32" @default.
- W2316532677 abstract "The intracellular class of proteins that bind the interleukin-2 suppressing drugs (cyclosporin, tacrolimus, and sirolimus) are called immunophilins. It is believed that the drugs do not act directly on T cells to cause immunosuppression. Instead, there is evidence that drug–immunophilin complexes are responsible for the therapeutic effect. In this work, evidence is presented that ubiquitin is an immunophilin. Ubiquitin is a highly conserved protein essential to an important pathway that targets proteins for proteolysis. The interaction of these drugs could cause accelerated proteolysis of a key protein for T-cell upregulation or could cause the inhibition of proteolysis of a T-cell suppressor. It was also shown that when ubiquitin is complexed with tacrolimus, the complex inhibits calcineurin phosphatase, and it is known that immunosuppression with these drugs occurs concurrently with a decrease in the activity of this enzyme. The discovery of ubiquitin as an immunophilin has opened many new avenues to explore in relation to the effects of these drugs." @default.
- W2316532677 created "2016-06-24" @default.
- W2316532677 creator A5024842070 @default.
- W2316532677 creator A5078142175 @default.
- W2316532677 date "2002-02-01" @default.
- W2316532677 modified "2023-10-14" @default.
- W2316532677 title "Protein Ubiquitin is an Immunophilin" @default.
- W2316532677 cites W1535070554 @default.
- W2316532677 cites W1969883378 @default.
- W2316532677 cites W1978879981 @default.
- W2316532677 cites W1981404996 @default.
- W2316532677 cites W1988271696 @default.
- W2316532677 cites W1992447833 @default.
- W2316532677 cites W2015174638 @default.
- W2316532677 cites W2018365938 @default.
- W2316532677 cites W2024842574 @default.
- W2316532677 cites W2027561633 @default.
- W2316532677 cites W2042844998 @default.
- W2316532677 cites W2066868766 @default.
- W2316532677 cites W2073234505 @default.
- W2316532677 cites W2083131818 @default.
- W2316532677 cites W2089850443 @default.
- W2316532677 cites W2091538386 @default.
- W2316532677 cites W2091676399 @default.
- W2316532677 cites W2093155377 @default.
- W2316532677 cites W2129752729 @default.
- W2316532677 cites W2156012420 @default.
- W2316532677 cites W2168839546 @default.
- W2316532677 cites W2169532909 @default.
- W2316532677 cites W2178503716 @default.
- W2316532677 cites W2321738727 @default.
- W2316532677 cites W2362925597 @default.
- W2316532677 doi "https://doi.org/10.1097/00007691-200202000-00006" @default.
- W2316532677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11805719" @default.
- W2316532677 hasPublicationYear "2002" @default.
- W2316532677 type Work @default.
- W2316532677 sameAs 2316532677 @default.
- W2316532677 citedByCount "7" @default.
- W2316532677 countsByYear W23165326772012 @default.
- W2316532677 countsByYear W23165326772016 @default.
- W2316532677 countsByYear W23165326772019 @default.
- W2316532677 crossrefType "journal-article" @default.
- W2316532677 hasAuthorship W2316532677A5024842070 @default.
- W2316532677 hasAuthorship W2316532677A5078142175 @default.
- W2316532677 hasConcept C104317684 @default.
- W2316532677 hasConcept C128057223 @default.
- W2316532677 hasConcept C133956753 @default.
- W2316532677 hasConcept C141071460 @default.
- W2316532677 hasConcept C178666793 @default.
- W2316532677 hasConcept C181199279 @default.
- W2316532677 hasConcept C185592680 @default.
- W2316532677 hasConcept C25602115 @default.
- W2316532677 hasConcept C2781307694 @default.
- W2316532677 hasConcept C2911091166 @default.
- W2316532677 hasConcept C55493867 @default.
- W2316532677 hasConcept C71924100 @default.
- W2316532677 hasConcept C86803240 @default.
- W2316532677 hasConcept C95444343 @default.
- W2316532677 hasConceptScore W2316532677C104317684 @default.
- W2316532677 hasConceptScore W2316532677C128057223 @default.
- W2316532677 hasConceptScore W2316532677C133956753 @default.
- W2316532677 hasConceptScore W2316532677C141071460 @default.
- W2316532677 hasConceptScore W2316532677C178666793 @default.
- W2316532677 hasConceptScore W2316532677C181199279 @default.
- W2316532677 hasConceptScore W2316532677C185592680 @default.
- W2316532677 hasConceptScore W2316532677C25602115 @default.
- W2316532677 hasConceptScore W2316532677C2781307694 @default.
- W2316532677 hasConceptScore W2316532677C2911091166 @default.
- W2316532677 hasConceptScore W2316532677C55493867 @default.
- W2316532677 hasConceptScore W2316532677C71924100 @default.
- W2316532677 hasConceptScore W2316532677C86803240 @default.
- W2316532677 hasConceptScore W2316532677C95444343 @default.
- W2316532677 hasIssue "1" @default.
- W2316532677 hasLocation W23165326771 @default.
- W2316532677 hasLocation W23165326772 @default.
- W2316532677 hasOpenAccess W2316532677 @default.
- W2316532677 hasPrimaryLocation W23165326771 @default.
- W2316532677 hasRelatedWork W1843531984 @default.
- W2316532677 hasRelatedWork W1967603109 @default.
- W2316532677 hasRelatedWork W1982869248 @default.
- W2316532677 hasRelatedWork W1984754431 @default.
- W2316532677 hasRelatedWork W2007540790 @default.
- W2316532677 hasRelatedWork W2023166792 @default.
- W2316532677 hasRelatedWork W2047106546 @default.
- W2316532677 hasRelatedWork W2080169144 @default.
- W2316532677 hasRelatedWork W2089579242 @default.
- W2316532677 hasRelatedWork W2593713688 @default.
- W2316532677 hasVolume "24" @default.
- W2316532677 isParatext "false" @default.
- W2316532677 isRetracted "false" @default.
- W2316532677 magId "2316532677" @default.
- W2316532677 workType "article" @default.