FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316537586> ?p ?o ?g. }

• W2316537586 endingPage "568" @default.
• W2316537586 startingPage "561" @default.
• W2316537586 abstract "To investigate the mechanism of Fuzheng Huayu recipe (FZHY), a compound traditional Chinese herbal medicine, against liver fibrosis related to transforming growth factor-β1 (TGF-β1)/Smads signaling transduction.The research consisted of in vitro and in vivo experiments. In the in vivo experiment, 37 male Wistar rats were divided into 3 groups: 5 rats in normal group, 18 and 14 rats respectively in model and FZHY groups. Liver fibrosis was induced in rats of the model group and the FZHY group by intraperitoneal injection of dimethylnitrosamine with a dose of 10μg/kg body weight for 4 weeks. Rats in the FZHY group were administered with FZHY for 4 weeks after liver fibrosis was induced. After the treatment of FZHY, hydroxyproline (Hyp) content in rat liver tissue was assayed by Jamall's method and protein expressions of TGF-β1, TGF-β1 receptor I (TβR-I), Smad2, Smad3 and phosphorylated-Smad2/3 were analyzed by Western blotting. In the in vitro experiment, hepatic stellate cells (HSCs) were isolated from normal rats by in situ pronase/collagenase perfusion followed by density gradient centrifugation. On the 4th day of cell culture, HSCs were stimulated by 2.5 ng/mL TGF-β1 for 24 h, then incubated with the medium containing 10% FZHY-medicated serum or 10μmol/L SB-431542 (a potent and specific inhibitor of TGF-β1 receptor I kinase) for 24 h. And the HSCs without TGF-β1 stimulating were used as control group. Protein expressions and location of α-smooth muscle actin (α-SMA) and Smad3 in HSCs were assayed by immunofluorescent staining, and the image was analyzed by Image-Pro Plus 6.1 System.In the in vivo experiment, liver Hyp content in the FZHY group was reduced significantly compared with the model group. FZHY also down-regulated the protein expressions of TGF-β1, TβR-I and p-Smad2/3 in fibrotic liver tissue. In the in vitro experiment, FZHY-medicated serum incubated with TGF-β1-stimulated HSCs significantly down-regulated the protein expression of α-SMA. It also inhibited Smad3 nuclear translocation in TGF-β1-stimulated HSCs.The mechanism of FZHY against liver fibrosis is related to the regulation of TGF-β1 signaling transduction pathway by inhibition of TGF-β1 and TβR-I expressions and Smads activation in fibrotic liver tissue and HSCs." @default.
• W2316537586 created "2016-06-24" @default.
• W2316537586 creator A5017467059 @default.
• W2316537586 creator A5031751057 @default.
• W2316537586 creator A5040059088 @default.
• W2316537586 creator A5067618472 @default.
• W2316537586 creator A5074880411 @default.
• W2316537586 date "2012-05-15" @default.
• W2316537586 modified "2023-10-16" @default.
• W2316537586 title "Chinese herbal medicine Fuzheng Huayu recipe inhibits liver fibrosis by mediating the transforming growth factor-β1/Smads signaling pathway" @default.
• W2316537586 cites W120657793 @default.
• W2316537586 cites W1597871970 @default.
• W2316537586 cites W1906235443 @default.
• W2316537586 cites W1928254388 @default.
• W2316537586 cites W1982406043 @default.
• W2316537586 cites W2008668619 @default.
• W2316537586 cites W2010145160 @default.
• W2316537586 cites W2025294090 @default.
• W2316537586 cites W2061053541 @default.
• W2316537586 cites W2065430432 @default.
• W2316537586 cites W2086367010 @default.
• W2316537586 cites W2097059462 @default.
• W2316537586 cites W2111288662 @default.
• W2316537586 cites W2117814548 @default.
• W2316537586 cites W2142988890 @default.
• W2316537586 cites W2159538695 @default.
• W2316537586 cites W2331324641 @default.
• W2316537586 cites W4212985336 @default.
• W2316537586 doi "https://doi.org/10.3736/jcim20120512" @default.
• W2316537586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22587979" @default.
• W2316537586 hasPublicationYear "2012" @default.
• W2316537586 type Work @default.
• W2316537586 sameAs 2316537586 @default.
• W2316537586 citedByCount "16" @default.
• W2316537586 countsByYear W23165375862015 @default.
• W2316537586 countsByYear W23165375862016 @default.
• W2316537586 countsByYear W23165375862017 @default.
• W2316537586 countsByYear W23165375862018 @default.
• W2316537586 countsByYear W23165375862019 @default.
• W2316537586 countsByYear W23165375862020 @default.
• W2316537586 countsByYear W23165375862022 @default.
• W2316537586 countsByYear W23165375862023 @default.
• W2316537586 crossrefType "journal-article" @default.
• W2316537586 hasAuthorship W2316537586A5017467059 @default.
• W2316537586 hasAuthorship W2316537586A5031751057 @default.
• W2316537586 hasAuthorship W2316537586A5040059088 @default.
• W2316537586 hasAuthorship W2316537586A5067618472 @default.
• W2316537586 hasAuthorship W2316537586A5074880411 @default.
• W2316537586 hasConcept C118131993 @default.
• W2316537586 hasConcept C126322002 @default.
• W2316537586 hasConcept C134018914 @default.
• W2316537586 hasConcept C150903083 @default.
• W2316537586 hasConcept C170493617 @default.
• W2316537586 hasConcept C176891718 @default.
• W2316537586 hasConcept C181199279 @default.
• W2316537586 hasConcept C185592680 @default.
• W2316537586 hasConcept C207001950 @default.
• W2316537586 hasConcept C2778394429 @default.
• W2316537586 hasConcept C2779797417 @default.
• W2316537586 hasConcept C2780159080 @default.
• W2316537586 hasConcept C55493867 @default.
• W2316537586 hasConcept C71924100 @default.
• W2316537586 hasConcept C86803240 @default.
• W2316537586 hasConcept C98274493 @default.
• W2316537586 hasConceptScore W2316537586C118131993 @default.
• W2316537586 hasConceptScore W2316537586C126322002 @default.
• W2316537586 hasConceptScore W2316537586C134018914 @default.
• W2316537586 hasConceptScore W2316537586C150903083 @default.
• W2316537586 hasConceptScore W2316537586C170493617 @default.
• W2316537586 hasConceptScore W2316537586C176891718 @default.
• W2316537586 hasConceptScore W2316537586C181199279 @default.
• W2316537586 hasConceptScore W2316537586C185592680 @default.
• W2316537586 hasConceptScore W2316537586C207001950 @default.
• W2316537586 hasConceptScore W2316537586C2778394429 @default.
• W2316537586 hasConceptScore W2316537586C2779797417 @default.
• W2316537586 hasConceptScore W2316537586C2780159080 @default.
• W2316537586 hasConceptScore W2316537586C55493867 @default.
• W2316537586 hasConceptScore W2316537586C71924100 @default.
• W2316537586 hasConceptScore W2316537586C86803240 @default.
• W2316537586 hasConceptScore W2316537586C98274493 @default.
• W2316537586 hasIssue "5" @default.
• W2316537586 hasLocation W23165375861 @default.
• W2316537586 hasLocation W23165375862 @default.
• W2316537586 hasOpenAccess W2316537586 @default.
• W2316537586 hasPrimaryLocation W23165375861 @default.
• W2316537586 hasRelatedWork W1964368655 @default.
• W2316537586 hasRelatedWork W1985910614 @default.
• W2316537586 hasRelatedWork W2060435101 @default.
• W2316537586 hasRelatedWork W2071797521 @default.
• W2316537586 hasRelatedWork W2289232604 @default.
• W2316537586 hasRelatedWork W2340574926 @default.
• W2316537586 hasRelatedWork W2364278627 @default.
• W2316537586 hasRelatedWork W2411352342 @default.
• W2316537586 hasRelatedWork W2414553945 @default.
• W2316537586 hasRelatedWork W2419034385 @default.
• W2316537586 hasVolume "10" @default.
• W2316537586 isParatext "false" @default.
• W2316537586 isRetracted "false" @default.

• next