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• W2316554325 abstract "Event Abstract Back to Event Electro-acupuncture upregulate alpha7 nAchR expression in hippocampus improving spatial memory in rats Jianying Tian1* and Tianqi Wang2 1 Ningxia Medical University, Department of Anatomy, China 2 Ningxia Medical University, China The expression of the alpha7 nicotinic acetylcholine receptor (alpha7 nAchR) diminishes in selected brain regions of patients with Alzheimer's Disease(AD) which may account for pathophysiological abnormalities and some of the deficits in attention and learning and working memory. There is emerging evidence that Yizhi Xingnao needling method have the effects of improveing in attention and memory in traditional Chinese medicine.Purpose: To investigate the effect of electroacupuncture (EA) stimulation at the acupoints on improving learning-memory ability and alpha7 nAchR expression in hippocampus tissue. Methods: SD rats were randomized into control, model group ,protective EA (pro-EA)group and EA group, with 10 cases in each. The model was established by administration of methyllycaconitine (MLA), a competitive alpha7 nAChR antagonist, 4.8mg/kg/d,for 10 days. For the pro-EA group and the EA group,after MLA treated, EA (2 Hz, 1mA)was applied to Baihui (GV 20), Dazhui (GV 14) and bilateral Shenshu(BL 23) and non-acupoint (the chest-abdominal juncture between the first and the second lumbar vertebrae) for 20 min, each time and on alternate days, continuously for 6 weeks. pro-EA group was applied one week additional EA before modeling.Morris water maze test was performed to detect the learning and memory ability . The expression of a7nAchR protein in hippocampal was measured by immunohistochemstry and Dot Blot.Results: The escape latencies on the 2nd day in model group were significantly longer than those of control group (P < 0.01) and swimming time in the platform quadrant were significantly shorter than those of control group (P<0.01). In comparison with model group, the escape latency of pro EA group on the 11th day and EA group on 18th day was significantly shorter (P < 0.05), and the time in the platform quadrant of EA group was significantly longer (P < 0.05). Compared to control group, the expression of alpha7 nAchR in hippocampal CA 3 region ,but not CA1 and dentate gyrus in pro-EA and EA groups decreased significantly (P<0.05). Compared to model group, the expression level of alpha7 nAchR in the hippocampal CA3 region increased markedly (P < 0.05). No significant difference was found between control and non-acupoint groups (P > 0.05).Conclusion: EA is able to exert beneficial effects on spatial memory which may be related to its effect on upregulating the expression of alpha7 nAchR in hippocampal CA3 region. Conference: Neuroinformatics 2010 , Kobe, Japan, 30 Aug - 1 Sep, 2010. Presentation Type: Poster Presentation Topic: General neuroinformatics Citation: Tian J and Wang T (2010). Electro-acupuncture upregulate alpha7 nAchR expression in hippocampus improving spatial memory in rats. Front. Neurosci. Conference Abstract: Neuroinformatics 2010 . doi: 10.3389/conf.fnins.2010.13.00017 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 09 Jun 2010; Published Online: 09 Jun 2010. * Correspondence: Jianying Tian, Ningxia Medical University, Department of Anatomy, Yinchuan, China, Tianjy@nxmu.edu.cn Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jianying Tian Tianqi Wang Google Jianying Tian Tianqi Wang Google Scholar Jianying Tian Tianqi Wang PubMed Jianying Tian Tianqi Wang Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2316554325 title "Electro-acupuncture upregulate alpha7 nAchR expression in hippocampus improving spatial memory in rats" @default.
• W2316554325 doi "https://doi.org/10.3389/conf.fnins.2010.13.00017" @default.
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