Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316571023> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2316571023 endingPage "578" @default.
- W2316571023 startingPage "573" @default.
- W2316571023 abstract "Slow-release metoprolol tartrate 120 mg tablets were given orally to 14 healthy male volunteers in the morning when fasting and after breakfast according to a cross-over design, and the influence of food intake on the bioavailability of the slow-release 120 mg tablet was examined.Serum samples were collected from healthy volunteers receiving slow-release 120 mg tablets in the morning when fasting, and the binding of metoprolol to serum protein in vivo was determined using ultrafiltration method. The mean peak concentration (Cmax) values (±SE) were 86.6±11.1ng/ml in the preprandial state, and 119.6±17.1ng/ml in the postprandial state, and the mean area under the concentration time curve (AUC0-24) values (±SE) were 896.7±150.3ng•hr/ml and 1140.0±196.0ng•hr/ml, respectively. The mean Cmax values and AUC0-24 values in the postprandial state were significantly higher than the corresponding values in the preprandial state, but the mean time to peak concentration (Tmax) values in the preprandial and postprandial state were not significant.The mean percentage of serum protein binding values at 4, 9 and 12 hr when fasting were 19.8%, 21.0% and 32.2%, respectively." @default.
- W2316571023 created "2016-06-24" @default.
- W2316571023 creator A5003769248 @default.
- W2316571023 creator A5021819365 @default.
- W2316571023 creator A5032450264 @default.
- W2316571023 creator A5051721192 @default.
- W2316571023 creator A5060692693 @default.
- W2316571023 creator A5082216081 @default.
- W2316571023 date "1991-01-01" @default.
- W2316571023 modified "2023-09-27" @default.
- W2316571023 title "The Influence of food on the bioavailability of slow-release metoprolol tartrate 120mg tablet in healthy volunteers and serum protein binding of metoprolol." @default.
- W2316571023 cites W187714522 @default.
- W2316571023 doi "https://doi.org/10.2133/dmpk.6.573" @default.
- W2316571023 hasPublicationYear "1991" @default.
- W2316571023 type Work @default.
- W2316571023 sameAs 2316571023 @default.
- W2316571023 citedByCount "0" @default.
- W2316571023 crossrefType "journal-article" @default.
- W2316571023 hasAuthorship W2316571023A5003769248 @default.
- W2316571023 hasAuthorship W2316571023A5021819365 @default.
- W2316571023 hasAuthorship W2316571023A5032450264 @default.
- W2316571023 hasAuthorship W2316571023A5051721192 @default.
- W2316571023 hasAuthorship W2316571023A5060692693 @default.
- W2316571023 hasAuthorship W2316571023A5082216081 @default.
- W2316571023 hasBestOaLocation W23165710231 @default.
- W2316571023 hasConcept C126322002 @default.
- W2316571023 hasConcept C134018914 @default.
- W2316571023 hasConcept C140793950 @default.
- W2316571023 hasConcept C181389837 @default.
- W2316571023 hasConcept C185592680 @default.
- W2316571023 hasConcept C19720800 @default.
- W2316571023 hasConcept C22979827 @default.
- W2316571023 hasConcept C2778199505 @default.
- W2316571023 hasConcept C2778345441 @default.
- W2316571023 hasConcept C2779306644 @default.
- W2316571023 hasConcept C2781280847 @default.
- W2316571023 hasConcept C2909447574 @default.
- W2316571023 hasConcept C31903555 @default.
- W2316571023 hasConcept C71924100 @default.
- W2316571023 hasConcept C86803240 @default.
- W2316571023 hasConcept C98274493 @default.
- W2316571023 hasConceptScore W2316571023C126322002 @default.
- W2316571023 hasConceptScore W2316571023C134018914 @default.
- W2316571023 hasConceptScore W2316571023C140793950 @default.
- W2316571023 hasConceptScore W2316571023C181389837 @default.
- W2316571023 hasConceptScore W2316571023C185592680 @default.
- W2316571023 hasConceptScore W2316571023C19720800 @default.
- W2316571023 hasConceptScore W2316571023C22979827 @default.
- W2316571023 hasConceptScore W2316571023C2778199505 @default.
- W2316571023 hasConceptScore W2316571023C2778345441 @default.
- W2316571023 hasConceptScore W2316571023C2779306644 @default.
- W2316571023 hasConceptScore W2316571023C2781280847 @default.
- W2316571023 hasConceptScore W2316571023C2909447574 @default.
- W2316571023 hasConceptScore W2316571023C31903555 @default.
- W2316571023 hasConceptScore W2316571023C71924100 @default.
- W2316571023 hasConceptScore W2316571023C86803240 @default.
- W2316571023 hasConceptScore W2316571023C98274493 @default.
- W2316571023 hasIssue "4" @default.
- W2316571023 hasLocation W23165710231 @default.
- W2316571023 hasOpenAccess W2316571023 @default.
- W2316571023 hasPrimaryLocation W23165710231 @default.
- W2316571023 hasRelatedWork W1977940558 @default.
- W2316571023 hasRelatedWork W2070038484 @default.
- W2316571023 hasRelatedWork W2093139537 @default.
- W2316571023 hasRelatedWork W2145666773 @default.
- W2316571023 hasRelatedWork W2313466420 @default.
- W2316571023 hasRelatedWork W2316571023 @default.
- W2316571023 hasRelatedWork W2330396868 @default.
- W2316571023 hasRelatedWork W2355382095 @default.
- W2316571023 hasRelatedWork W2389869137 @default.
- W2316571023 hasRelatedWork W2416234618 @default.
- W2316571023 hasVolume "6" @default.
- W2316571023 isParatext "false" @default.
- W2316571023 isRetracted "false" @default.
- W2316571023 magId "2316571023" @default.
- W2316571023 workType "article" @default.