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• W2316572695 abstract "Event Abstract Back to Event Peripheral quantitative computed tomography to study skeletal maturity KA Ward1*, J Thompson1, D Harnpanich1, M Ceesay2, M Mendy2 and A Prentice1 1 MRC Human Nutrition Research, United Kingdom 2 MRC Keneba, Gambia Growth plate fusion is a marker of cessation of longitudinal growth. The appearance and disappearance of growth plates is used to give a child a bone age which reflects their growth relative to maturity rather than chronological age. In Africa stunting is common and growth velocities often slower. Qualitative observations have suggested growth occurs well into the third decade. The present study aimed to i) determine whether peripheral quantitative computed tomography (pQCT) could be used to study growth status and ii) whether there is evidence for growth in females who have had at least one pregnancy).{BR}As part of an on-going study of skeletal phenotype in The Gambia we have acquired a longitudinal pQCT scans at the radius and tibia. A scout view is taken of the distal site to determine scan location; from this is it possible to visualise the growth plate. A scoring system was developed grading scout views as open, partially fused, or fused. {BR}Males and females aged 17-25 years old were scanned; 3 groups were studied males (M), females who were non pregnant, none lactating (NPNL), females who had at least on pregnancy (PF). At time of last measurement 77% M, 100% NPNL had fused growth plates at radius, 19% M were partially fused. At the tibia 30%, 0% fused; 70% and 100% partially fused in M & NPNL respectively. Similar patterns were found in PF whereby tibia was less mature than the radius and even those who had at least on reproductive cycle there was evidence for partially fused growth plate. During the study period, statural height increased in the study population, particularly in boys.{BR}These data demonstrate evidence for continued growth in young Gambian adults with a difference in the timing of completion of growth between non weight bearing and weight bearing sites. There also appeared to be evidence of growth in females with at least one reproductive cycle. The consequences of this for nutrient partitioning between mother and child requires follow-up. The implications of these observations for development of a healthy skeletal phenotype and timing of interventions require further study. Keywords: Bones, Bone Research Conference: 2011 joint meeting of the Bone Research Society & the British Orthopaedic Research Society, Cambridge, United Kingdom, 27 Jun - 29 Jun, 2011. Presentation Type: Poster Topic: Abstracts Citation: Ward K, Thompson J, Harnpanich D, Ceesay M, Mendy M and Prentice A (2011). Peripheral quantitative computed tomography to study skeletal maturity. Front. Endocrinol. Conference Abstract: 2011 joint meeting of the Bone Research Society & the British Orthopaedic Research Society. doi: 10.3389/conf.fendo.2011.02.00072 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Sep 2011; Published Online: 30 Sep 2011. * Correspondence: Dr. KA Ward, MRC Human Nutrition Research, Cambridge, United Kingdom, kw@mrc.soton.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers KA Ward J Thompson D Harnpanich M Ceesay M Mendy A Prentice Google KA Ward J Thompson D Harnpanich M Ceesay M Mendy A Prentice Google Scholar KA Ward J Thompson D Harnpanich M Ceesay M Mendy A Prentice PubMed KA Ward J Thompson D Harnpanich M Ceesay M Mendy A Prentice Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2316572695 title "Peripheral quantitative computed tomography to study skeletal maturity" @default.
• W2316572695 doi "https://doi.org/10.3389/conf.fendo.2011.02.00072" @default.
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