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- W2316577567 abstract "In the study of the chemical regulation of respiration a need for a continuous method of recording changes in the hydrogen ion concentration of the circulating arterial and venous blood was felt. Such a method has been developed. By means of a specially devised electrode vessel, a manganese dioxide electrode was placed in the circulating blood. The chain was closed with a non-polarizable electrode, and the E. M. F. recorded potentiometrically on smoked paper by means of a writing point attached to the hard rubber drum of a Leeds and Nor-thrup type K potentiometer. The continuity of the method, the facility of recording changes in CH+, the amount of data obtainable from single animals, and the possibility of recording synchronous changes in CH+ in the arterial and venous blood along with changes in pulmonary ventilation, oxygen consumption, blood pressure, etc., are advantages which make the method extremely valuable. In experiments so far performed the method has shown characteristic changes in the CH+ of the blood with various procedures. The administration of CO2 eliciting increased pulmonary ventilation was accompanied by a sharp rise in the CH+ of the arterial blood, followed by a slower fall in CH+ during recovery. The intravenous injection of NaHCO3, produced a sudden fall in the CH+ of the arterial blood, followed by a slow return to normal. Though the changes in CH+ were large they were unaccompanied by changes in pulmonary ventilation. See Figure 1. Occlusion and de-occlusion of the trachea produced typical changes in blood pressure and respiration. The CH+ record resembled in detail the form of the blood pressure record. A record of such an experiment is shown in Figure 2. The administration of rarefied air eliciting increased pulmonary ventilation was accompanied by a decrease in the CH+ of the arterial blood. Subsequent administration of room air was followed by a further short but sudden decrease in CH+, giving way to an increased CH+." @default.
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- W2316577567 date "1925-02-01" @default.
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- W2316577567 title "Continuous recording changes in hydrogen ion concentration of circulating blood: The relation to respiration." @default.
- W2316577567 doi "https://doi.org/10.3181/00379727-22-143" @default.
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