FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316578031> ?p ?o ?g. }

• W2316578031 endingPage "3743" @default.
• W2316578031 startingPage "3737" @default.
• W2316578031 abstract "Currently there is limited information available on the accuracy and precision of relative isotopic abundance (RIA) measurements using high-resolution direct-infusion mass spectrometry (HR DIMS), and it is unclear if this information can benefit automated peak annotation in metabolomics. Here we characterize the accuracy of RIA measurements on the Thermo LTQ FT Ultra (resolution of 100 000–750 000) and LTQ Orbitrap (R = 100 000) mass spectrometers. This first involved reoptimizing the SIM-stitching method (Southam, A. D.Anal. Chem. 2007, 79, 4595−4602) for the LTQ FT Ultra, which achieved a ca. 3-fold sensitivity increase compared to the original method while maintaining a root-mean-squared mass error of 0.16 ppm. Using this method, we show the quality of RIA measurements is highly dependent on signal-to-noise ratio (SNR), with RIA accuracy increasing with higher SNR. Furthermore, a negative offset between the theoretical and empirically calculated numbers of carbon atoms was observed for both mass spectrometers. Increasing the resolution of the LTQ FT Ultra lowered both the sensitivity and the quality of RIA measurements. Overall, although the errors in the empirically calculated number of carbons can be large (e.g., 10 carbons), we demonstrate that RIA measurements do improve automated peak annotation, increasing the number of single empirical formula assignments by >3-fold compared to using accurate mass alone." @default.
• W2316578031 created "2016-06-24" @default.
• W2316578031 creator A5025526658 @default.
• W2316578031 creator A5055611974 @default.
• W2316578031 creator A5065318374 @default.
• W2316578031 creator A5082395364 @default.
• W2316578031 date "2011-04-19" @default.
• W2316578031 modified "2023-10-18" @default.
• W2316578031 title "Characterization of Isotopic Abundance Measurements in High Resolution FT-ICR and Orbitrap Mass Spectra for Improved Confidence of Metabolite Identification" @default.
• W2316578031 cites W1480161928 @default.
• W2316578031 cites W1964390274 @default.
• W2316578031 cites W1971983473 @default.
• W2316578031 cites W1979597489 @default.
• W2316578031 cites W1995415001 @default.
• W2316578031 cites W2011022636 @default.
• W2316578031 cites W2015503332 @default.
• W2316578031 cites W2019904349 @default.
• W2316578031 cites W2022574837 @default.
• W2316578031 cites W2033488880 @default.
• W2316578031 cites W2050154334 @default.
• W2316578031 cites W2064535527 @default.
• W2316578031 cites W2067519806 @default.
• W2316578031 cites W2068542211 @default.
• W2316578031 cites W2078547650 @default.
• W2316578031 cites W2087490875 @default.
• W2316578031 cites W2094820379 @default.
• W2316578031 cites W2095133506 @default.
• W2316578031 cites W2132833265 @default.
• W2316578031 cites W2140181854 @default.
• W2316578031 cites W2140695271 @default.
• W2316578031 cites W2140843074 @default.
• W2316578031 cites W2147443546 @default.
• W2316578031 cites W2154631167 @default.
• W2316578031 cites W2156858669 @default.
• W2316578031 cites W2163587256 @default.
• W2316578031 doi "https://doi.org/10.1021/ac2001803" @default.
• W2316578031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21466230" @default.
• W2316578031 hasPublicationYear "2011" @default.
• W2316578031 type Work @default.
• W2316578031 sameAs 2316578031 @default.
• W2316578031 citedByCount "101" @default.
• W2316578031 countsByYear W23165780312012 @default.
• W2316578031 countsByYear W23165780312013 @default.
• W2316578031 countsByYear W23165780312014 @default.
• W2316578031 countsByYear W23165780312015 @default.
• W2316578031 countsByYear W23165780312016 @default.
• W2316578031 countsByYear W23165780312017 @default.
• W2316578031 countsByYear W23165780312018 @default.
• W2316578031 countsByYear W23165780312019 @default.
• W2316578031 countsByYear W23165780312020 @default.
• W2316578031 countsByYear W23165780312021 @default.
• W2316578031 countsByYear W23165780312022 @default.
• W2316578031 countsByYear W23165780312023 @default.
• W2316578031 crossrefType "journal-article" @default.
• W2316578031 hasAuthorship W2316578031A5025526658 @default.
• W2316578031 hasAuthorship W2316578031A5055611974 @default.
• W2316578031 hasAuthorship W2316578031A5065318374 @default.
• W2316578031 hasAuthorship W2316578031A5082395364 @default.
• W2316578031 hasConcept C105795698 @default.
• W2316578031 hasConcept C113196181 @default.
• W2316578031 hasConcept C138268822 @default.
• W2316578031 hasConcept C154945302 @default.
• W2316578031 hasConcept C162356407 @default.
• W2316578031 hasConcept C185592680 @default.
• W2316578031 hasConcept C186060115 @default.
• W2316578031 hasConcept C202799725 @default.
• W2316578031 hasConcept C2780841973 @default.
• W2316578031 hasConcept C33923547 @default.
• W2316578031 hasConcept C41008148 @default.
• W2316578031 hasConcept C43617362 @default.
• W2316578031 hasConcept C86803240 @default.
• W2316578031 hasConceptScore W2316578031C105795698 @default.
• W2316578031 hasConceptScore W2316578031C113196181 @default.
• W2316578031 hasConceptScore W2316578031C138268822 @default.
• W2316578031 hasConceptScore W2316578031C154945302 @default.
• W2316578031 hasConceptScore W2316578031C162356407 @default.
• W2316578031 hasConceptScore W2316578031C185592680 @default.
• W2316578031 hasConceptScore W2316578031C186060115 @default.
• W2316578031 hasConceptScore W2316578031C202799725 @default.
• W2316578031 hasConceptScore W2316578031C2780841973 @default.
• W2316578031 hasConceptScore W2316578031C33923547 @default.
• W2316578031 hasConceptScore W2316578031C41008148 @default.
• W2316578031 hasConceptScore W2316578031C43617362 @default.
• W2316578031 hasConceptScore W2316578031C86803240 @default.
• W2316578031 hasIssue "10" @default.
• W2316578031 hasLocation W23165780311 @default.
• W2316578031 hasLocation W23165780312 @default.
• W2316578031 hasOpenAccess W2316578031 @default.
• W2316578031 hasPrimaryLocation W23165780311 @default.
• W2316578031 hasRelatedWork W1969949619 @default.
• W2316578031 hasRelatedWork W1972516621 @default.
• W2316578031 hasRelatedWork W2026642978 @default.
• W2316578031 hasRelatedWork W2080147620 @default.
• W2316578031 hasRelatedWork W2157970971 @default.
• W2316578031 hasRelatedWork W2371154968 @default.
• W2316578031 hasRelatedWork W2742173843 @default.
• W2316578031 hasRelatedWork W2829482732 @default.
• W2316578031 hasRelatedWork W3109604139 @default.

• next