Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316592114> ?p ?o ?g. }
- W2316592114 endingPage "H523" @default.
- W2316592114 startingPage "H515" @default.
- W2316592114 abstract "The physiological role of the vasoconstrictive hormones arginine vasopressin (AVP) and angiotensin II (ANG II) in the development of vascular hyperplasia is still unclear. We examined the effects of these hormones on cell cycle regulation of cultured rat vascular smooth muscle cells (VSMC). AVP and ANG II were able to induce G(1)/S transition and DNA synthesis in serum-starved quiescent VSMC but failed to promote further progression into G(2)/M phases. AVP and ANG II enhanced the expression and activity of cdk2, cyclin E, and proliferating cell nuclear antigen but did not induce expression of cdc2/cyclin B complex, a critical regulator of G(2)/M transition. The failure of cdc2 mRNA induction was found to be caused by a defect in cdc2 promoter activation. Binding of free E2F-1 to the cdc2 promoter did not occur in hormone-treated VSMC, which may account for the defective induction of cdc2. The absence of cdc2 promoter activation and G(2)/M transition may be important for the prevention of hyperplasia under physiological conditions but underlies the hypertrophy of VSMC." @default.
- W2316592114 created "2016-06-24" @default.
- W2316592114 creator A5004329352 @default.
- W2316592114 creator A5012371496 @default.
- W2316592114 creator A5014484265 @default.
- W2316592114 creator A5031378537 @default.
- W2316592114 creator A5032481392 @default.
- W2316592114 creator A5051683488 @default.
- W2316592114 creator A5072205946 @default.
- W2316592114 date "1999-08-01" @default.
- W2316592114 modified "2023-09-27" @default.
- W2316592114 title "Failure of cdc2 promoter activation and G2/M transition by ANG II and AVP in vascular smooth muscle cells" @default.
- W2316592114 cites W1480117485 @default.
- W2316592114 cites W1489414711 @default.
- W2316592114 cites W1534302336 @default.
- W2316592114 cites W1631517817 @default.
- W2316592114 cites W1663047717 @default.
- W2316592114 cites W1787712636 @default.
- W2316592114 cites W1891141800 @default.
- W2316592114 cites W1896727857 @default.
- W2316592114 cites W1966700765 @default.
- W2316592114 cites W1972557244 @default.
- W2316592114 cites W1974778979 @default.
- W2316592114 cites W1975108132 @default.
- W2316592114 cites W1990132316 @default.
- W2316592114 cites W1993243592 @default.
- W2316592114 cites W1994292735 @default.
- W2316592114 cites W1995928382 @default.
- W2316592114 cites W1996530399 @default.
- W2316592114 cites W1997643531 @default.
- W2316592114 cites W2001870404 @default.
- W2316592114 cites W2005431808 @default.
- W2316592114 cites W2006739286 @default.
- W2316592114 cites W2008494281 @default.
- W2316592114 cites W2014575233 @default.
- W2316592114 cites W2015446431 @default.
- W2316592114 cites W2024219876 @default.
- W2316592114 cites W2026575473 @default.
- W2316592114 cites W2039741976 @default.
- W2316592114 cites W2054399854 @default.
- W2316592114 cites W2054844747 @default.
- W2316592114 cites W2065882690 @default.
- W2316592114 cites W2068611486 @default.
- W2316592114 cites W2070983017 @default.
- W2316592114 cites W2071782926 @default.
- W2316592114 cites W2087375731 @default.
- W2316592114 cites W2093290398 @default.
- W2316592114 cites W2094516179 @default.
- W2316592114 cites W2102242413 @default.
- W2316592114 cites W2104567339 @default.
- W2316592114 cites W2117939247 @default.
- W2316592114 cites W2123292462 @default.
- W2316592114 cites W2123930515 @default.
- W2316592114 cites W2135125719 @default.
- W2316592114 cites W2144206181 @default.
- W2316592114 cites W2169927110 @default.
- W2316592114 cites W2172140351 @default.
- W2316592114 cites W81266651 @default.
- W2316592114 cites W97469372 @default.
- W2316592114 doi "https://doi.org/10.1152/ajpheart.1999.277.2.h515" @default.
- W2316592114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10444476" @default.
- W2316592114 hasPublicationYear "1999" @default.
- W2316592114 type Work @default.
- W2316592114 sameAs 2316592114 @default.
- W2316592114 citedByCount "3" @default.
- W2316592114 crossrefType "journal-article" @default.
- W2316592114 hasAuthorship W2316592114A5004329352 @default.
- W2316592114 hasAuthorship W2316592114A5012371496 @default.
- W2316592114 hasAuthorship W2316592114A5014484265 @default.
- W2316592114 hasAuthorship W2316592114A5031378537 @default.
- W2316592114 hasAuthorship W2316592114A5032481392 @default.
- W2316592114 hasAuthorship W2316592114A5051683488 @default.
- W2316592114 hasAuthorship W2316592114A5072205946 @default.
- W2316592114 hasConcept C104317684 @default.
- W2316592114 hasConcept C126322002 @default.
- W2316592114 hasConcept C134018914 @default.
- W2316592114 hasConcept C185592680 @default.
- W2316592114 hasConcept C194232998 @default.
- W2316592114 hasConcept C2779395532 @default.
- W2316592114 hasConcept C2992686903 @default.
- W2316592114 hasConcept C54355233 @default.
- W2316592114 hasConcept C71924100 @default.
- W2316592114 hasConcept C86803240 @default.
- W2316592114 hasConcept C95444343 @default.
- W2316592114 hasConceptScore W2316592114C104317684 @default.
- W2316592114 hasConceptScore W2316592114C126322002 @default.
- W2316592114 hasConceptScore W2316592114C134018914 @default.
- W2316592114 hasConceptScore W2316592114C185592680 @default.
- W2316592114 hasConceptScore W2316592114C194232998 @default.
- W2316592114 hasConceptScore W2316592114C2779395532 @default.
- W2316592114 hasConceptScore W2316592114C2992686903 @default.
- W2316592114 hasConceptScore W2316592114C54355233 @default.
- W2316592114 hasConceptScore W2316592114C71924100 @default.
- W2316592114 hasConceptScore W2316592114C86803240 @default.
- W2316592114 hasConceptScore W2316592114C95444343 @default.
- W2316592114 hasIssue "2" @default.
- W2316592114 hasLocation W23165921141 @default.
- W2316592114 hasLocation W23165921142 @default.