FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316606009> ?p ?o ?g. }

• W2316606009 endingPage "1240" @default.
• W2316606009 startingPage "1231" @default.
• W2316606009 abstract "Piwi-like protein 2 (Piwil2) has recently emerged as a putative oncogene which is amplified in several human malignancies. However, the role of Piwil2 in colon cancer remains poorly understood. The aim of this study was to investigate the clinical and pathological significance of Piwil2, and the possible role in the proliferation and metastasis of colon cancer. Primary colon cancer paired with adjacent normal colon tissue and lymph node metastasis (LNM) lesions in 66 patients’ tissue microarrays (TMA) were used to determine the expression of Piwil2. Knocked down Piwil2 expression in SW620 and SW480 colon cancer cell lines was performed to evaluate the role of Piwil2 in cell proliferation, invasion, metastasis in vitro and tumorigenecity in vivo. The possible roles of Piwil2 in the regulation of a 2 kb matrix metallopeptidase 9 (MMP9) promoter fragment and on the regulation of apoptotic pathways were evaluated by using a luciferase reporter construct and Western blots, respectively. Significantly higher expression levels of Piwil2 were observed in primary colon cancer tissue and in LNM in comparison with normal colon mucosa. Piwil2 expression significantly correlated with more aggressive clinical and pathological parameters with poorer five-year metastasis-free survival and overall survival. Piwil2 silencing significantly reduced cancer cell proliferation, colony formation ability and increased apoptosis in vitro and inhibited tumor growth in vivo. Piwil2 knockdown also attenuated migration and invasion of colon cancer cells via modulation of MMP9 transcriptional activities. Our results indicate that Piwil2 moderates the proliferation and metastasis potential of colon cancer." @default.
• W2316606009 created "2016-06-24" @default.
• W2316606009 creator A5003744584 @default.
• W2316606009 creator A5004512291 @default.
• W2316606009 creator A5026178971 @default.
• W2316606009 creator A5052095213 @default.
• W2316606009 creator A5070212853 @default.
• W2316606009 creator A5071773097 @default.
• W2316606009 creator A5082761011 @default.
• W2316606009 date "2012-10-01" @default.
• W2316606009 modified "2023-09-26" @default.
• W2316606009 title "Piwil2 modulates the proliferation and metastasis of colon cancer via regulation of matrix metallopeptidase 9 transcriptional activity" @default.
• W2316606009 cites W1845807280 @default.
• W2316606009 cites W1965124339 @default.
• W2316606009 cites W1976191537 @default.
• W2316606009 cites W1994429466 @default.
• W2316606009 cites W2005334224 @default.
• W2316606009 cites W2034502325 @default.
• W2316606009 cites W2034916462 @default.
• W2316606009 cites W2035251095 @default.
• W2316606009 cites W2040577960 @default.
• W2316606009 cites W2041306541 @default.
• W2316606009 cites W2041983260 @default.
• W2316606009 cites W2052016345 @default.
• W2316606009 cites W2053449782 @default.
• W2316606009 cites W2060345644 @default.
• W2316606009 cites W2072407844 @default.
• W2316606009 cites W2093545250 @default.
• W2316606009 cites W2099950781 @default.
• W2316606009 cites W2102085111 @default.
• W2316606009 cites W2121350246 @default.
• W2316606009 cites W2124255173 @default.
• W2316606009 cites W2126002765 @default.
• W2316606009 cites W2129545382 @default.
• W2316606009 cites W2133058137 @default.
• W2316606009 cites W2141829495 @default.
• W2316606009 cites W2148492370 @default.
• W2316606009 cites W2155256293 @default.
• W2316606009 cites W4236272075 @default.
• W2316606009 doi "https://doi.org/10.1258/ebm.2012.011380" @default.
• W2316606009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23104504" @default.
• W2316606009 hasPublicationYear "2012" @default.
• W2316606009 type Work @default.
• W2316606009 sameAs 2316606009 @default.
• W2316606009 citedByCount "47" @default.
• W2316606009 countsByYear W23166060092013 @default.
• W2316606009 countsByYear W23166060092014 @default.
• W2316606009 countsByYear W23166060092015 @default.
• W2316606009 countsByYear W23166060092016 @default.
• W2316606009 countsByYear W23166060092017 @default.
• W2316606009 countsByYear W23166060092018 @default.
• W2316606009 countsByYear W23166060092019 @default.
• W2316606009 countsByYear W23166060092020 @default.
• W2316606009 countsByYear W23166060092021 @default.
• W2316606009 countsByYear W23166060092022 @default.
• W2316606009 countsByYear W23166060092023 @default.
• W2316606009 crossrefType "journal-article" @default.
• W2316606009 hasAuthorship W2316606009A5003744584 @default.
• W2316606009 hasAuthorship W2316606009A5004512291 @default.
• W2316606009 hasAuthorship W2316606009A5026178971 @default.
• W2316606009 hasAuthorship W2316606009A5052095213 @default.
• W2316606009 hasAuthorship W2316606009A5070212853 @default.
• W2316606009 hasAuthorship W2316606009A5071773097 @default.
• W2316606009 hasAuthorship W2316606009A5082761011 @default.
• W2316606009 hasConcept C104317684 @default.
• W2316606009 hasConcept C119056186 @default.
• W2316606009 hasConcept C121608353 @default.
• W2316606009 hasConcept C127561419 @default.
• W2316606009 hasConcept C147724379 @default.
• W2316606009 hasConcept C166703698 @default.
• W2316606009 hasConcept C173396325 @default.
• W2316606009 hasConcept C190283241 @default.
• W2316606009 hasConcept C2775997469 @default.
• W2316606009 hasConcept C2779013556 @default.
• W2316606009 hasConcept C2781018059 @default.
• W2316606009 hasConcept C29537977 @default.
• W2316606009 hasConcept C502942594 @default.
• W2316606009 hasConcept C526805850 @default.
• W2316606009 hasConcept C54355233 @default.
• W2316606009 hasConcept C62112901 @default.
• W2316606009 hasConcept C67705224 @default.
• W2316606009 hasConcept C86803240 @default.
• W2316606009 hasConceptScore W2316606009C104317684 @default.
• W2316606009 hasConceptScore W2316606009C119056186 @default.
• W2316606009 hasConceptScore W2316606009C121608353 @default.
• W2316606009 hasConceptScore W2316606009C127561419 @default.
• W2316606009 hasConceptScore W2316606009C147724379 @default.
• W2316606009 hasConceptScore W2316606009C166703698 @default.
• W2316606009 hasConceptScore W2316606009C173396325 @default.
• W2316606009 hasConceptScore W2316606009C190283241 @default.
• W2316606009 hasConceptScore W2316606009C2775997469 @default.
• W2316606009 hasConceptScore W2316606009C2779013556 @default.
• W2316606009 hasConceptScore W2316606009C2781018059 @default.
• W2316606009 hasConceptScore W2316606009C29537977 @default.
• W2316606009 hasConceptScore W2316606009C502942594 @default.
• W2316606009 hasConceptScore W2316606009C526805850 @default.
• W2316606009 hasConceptScore W2316606009C54355233 @default.
• W2316606009 hasConceptScore W2316606009C62112901 @default.

• next