Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316608115> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2316608115 abstract "Abstract #6130 Background: Breast cancer (BC) therapies have been associated with decreases in bone health. Recent studies have shown that BC survivors have a 31% increased fracture risk compared with their peers, elevating the importance of monitoring bone health in women diagnosed with BC. Bone mineral density (BMD) has been the standard used by clinical guidelines (WHO, ASCO) to direct therapeutic decisions. However, emerging guidelines place BMD in the context of several other clinical risk factors that have been correlated with overall fracture risk. This retrospective, case-controlled study uses current and emerging guidelines to estimate the percentage of patients with newly diagnosed breast cancer who may be at increased risk for fracture and who require preventive therapy. Methods: Baseline data from 88 pre- and 402 postmenopausal women (PMW) with BC were compared with data from an equal number of healthy age- and body mass index-matched women. BMD was assessed by 2 methods; dual-energy x-ray absorptiometry (DXA) at the lumbar spine (LS) and total hip, and quantitative ultrasonometry (QUS) at the os calcaneus and phalanges. Baseline BMD measurements were collected at a mean duration of 15 and 242 days after diagnosis of cancer in pre- and PMW, respectively. Results: Baseline LS and total hip BMD was similar between the healthy control groups and patients with BC. Among estrogen receptor-positive (ER+) BC patients, 18.8% of premenopausal women and 36.9% of PMW were osteopenic, and 8.9% of PMW were osteoporotic (according to LS BMD). Among ER+ PMW with BC, 15.9% of patients > 65 years of age, 8.3% of patients 55 to 65 years of age, and 1.4% of patients Conclusions: Current treatment thresholds seem to inadequately identify patients who would benefit from bone-protective therapy. The results presented here support the use of overall fracture risk assessment in PMW with breast cancer. Using both BMD and clinical risk factors may more effectively identify patients at risk for fracture, although further studies are needed. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6130." @default.
- W2316608115 created "2016-06-24" @default.
- W2316608115 creator A5016290825 @default.
- W2316608115 creator A5016838561 @default.
- W2316608115 creator A5026364343 @default.
- W2316608115 creator A5028450771 @default.
- W2316608115 creator A5070338465 @default.
- W2316608115 date "2009-01-15" @default.
- W2316608115 modified "2023-09-27" @default.
- W2316608115 title "Fracture risk in women with breast cancer: can baseline assessment of risk be used to guide treatment?." @default.
- W2316608115 doi "https://doi.org/10.1158/0008-5472.sabcs-6130" @default.
- W2316608115 hasPublicationYear "2009" @default.
- W2316608115 type Work @default.
- W2316608115 sameAs 2316608115 @default.
- W2316608115 citedByCount "0" @default.
- W2316608115 crossrefType "proceedings-article" @default.
- W2316608115 hasAuthorship W2316608115A5016290825 @default.
- W2316608115 hasAuthorship W2316608115A5016838561 @default.
- W2316608115 hasAuthorship W2316608115A5026364343 @default.
- W2316608115 hasAuthorship W2316608115A5028450771 @default.
- W2316608115 hasAuthorship W2316608115A5070338465 @default.
- W2316608115 hasConcept C121608353 @default.
- W2316608115 hasConcept C126322002 @default.
- W2316608115 hasConcept C141071460 @default.
- W2316608115 hasConcept C151730666 @default.
- W2316608115 hasConcept C1862650 @default.
- W2316608115 hasConcept C2776541429 @default.
- W2316608115 hasConcept C2776886416 @default.
- W2316608115 hasConcept C2776889875 @default.
- W2316608115 hasConcept C2779343474 @default.
- W2316608115 hasConcept C2780221984 @default.
- W2316608115 hasConcept C29456083 @default.
- W2316608115 hasConcept C530470458 @default.
- W2316608115 hasConcept C71924100 @default.
- W2316608115 hasConcept C86803240 @default.
- W2316608115 hasConceptScore W2316608115C121608353 @default.
- W2316608115 hasConceptScore W2316608115C126322002 @default.
- W2316608115 hasConceptScore W2316608115C141071460 @default.
- W2316608115 hasConceptScore W2316608115C151730666 @default.
- W2316608115 hasConceptScore W2316608115C1862650 @default.
- W2316608115 hasConceptScore W2316608115C2776541429 @default.
- W2316608115 hasConceptScore W2316608115C2776886416 @default.
- W2316608115 hasConceptScore W2316608115C2776889875 @default.
- W2316608115 hasConceptScore W2316608115C2779343474 @default.
- W2316608115 hasConceptScore W2316608115C2780221984 @default.
- W2316608115 hasConceptScore W2316608115C29456083 @default.
- W2316608115 hasConceptScore W2316608115C530470458 @default.
- W2316608115 hasConceptScore W2316608115C71924100 @default.
- W2316608115 hasConceptScore W2316608115C86803240 @default.
- W2316608115 hasLocation W23166081151 @default.
- W2316608115 hasOpenAccess W2316608115 @default.
- W2316608115 hasPrimaryLocation W23166081151 @default.
- W2316608115 hasRelatedWork W1976994799 @default.
- W2316608115 hasRelatedWork W1994491838 @default.
- W2316608115 hasRelatedWork W1998331007 @default.
- W2316608115 hasRelatedWork W2003835736 @default.
- W2316608115 hasRelatedWork W2041118764 @default.
- W2316608115 hasRelatedWork W2048954280 @default.
- W2316608115 hasRelatedWork W2068025211 @default.
- W2316608115 hasRelatedWork W2331955939 @default.
- W2316608115 hasRelatedWork W2415168706 @default.
- W2316608115 hasRelatedWork W2616052939 @default.
- W2316608115 hasRelatedWork W2620837469 @default.
- W2316608115 hasRelatedWork W2747395163 @default.
- W2316608115 hasRelatedWork W2808784780 @default.
- W2316608115 hasRelatedWork W2894643037 @default.
- W2316608115 hasRelatedWork W2932354804 @default.
- W2316608115 hasRelatedWork W3002024499 @default.
- W2316608115 hasRelatedWork W3022797057 @default.
- W2316608115 hasRelatedWork W3045256074 @default.
- W2316608115 hasRelatedWork W3097195994 @default.
- W2316608115 hasRelatedWork W3180656799 @default.
- W2316608115 isParatext "false" @default.
- W2316608115 isRetracted "false" @default.
- W2316608115 magId "2316608115" @default.
- W2316608115 workType "article" @default.