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• W2316646022 startingPage "3029" @default.
• W2316646022 abstract "The exploration of biocompatible quantum dots (QDs) for biomedical imaging is currently one of the fastest growing fields of nanotechnology. This strategy overcomes the intrinsic toxicity of well-developed II–VI and other semiconductor QDs (Cd, Hg, Pb, Se, Te, As, etc.) that remains a major obstacle to their clinical use. In this report, we synthesized high-quality CuInS2/ZnS (CIS/ZnS) QDs without using conventional toxic heavy metals. These QDs exhibited improved photoluminescence (PL) properties, with tunable emission peaks ranging from 550 to 800 nm and a maximum PL quantum yield (QY) up to 80%. Next, we explored the effective loading of the prepared oil-soluble CIS/ZnS QDs using biodegradable folate-modified N-succinyl-N′-octyl chitosan (FA-SOC) micelles. Targeting efficacy of the resulting QDs-loaded micelles to tumors using in vitro and in vivo optical imaging techniques was also investigated. The results show that the micelle platform allowed successful formulation of these oil-soluble QDs in water, while retaining the morphology, crystal structure, and PL of the initial CIS/ZnS QDs. This study demonstrates the versatility of using the biocompatible CIS/ZnS QDs across different spatial scales (in vitro cell imaging and in vivo small animal imaging) for multicolor biological imaging applications." @default.
• W2316646022 created "2016-06-24" @default.
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• W2316646022 date "2012-07-31" @default.
• W2316646022 modified "2023-10-17" @default.
• W2316646022 title "High-Quality CuInS₂/ZnS Quantum Dots for In vitro and In vivo Bioimaging" @default.
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• W2316646022 doi "https://doi.org/10.1021/cm3015594" @default.
• W2316646022 hasPublicationYear "2012" @default.
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