FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316656192> ?p ?o ?g. }

• W2316656192 abstract "Objectives: A novel topical formulation of lipid based amphotericin B (0.1% amphotericin B Gel) was developed to assess the safety, tolerability and efficacy in adult patients with cutaneous and/or mucocutaneous fungal infection.Methods: Amphotericin B gel was formulated using lipids. In vitro release assay of amphotericin B was measured using paddle apparatus maintained at 37.0° ± 0.5°C. The stability studies of amphotericin B gel were carried out at 2-8°C, 25°C and 40°C. To test the effect of the drug in clinical setting, 100 patients with recurrent case after failure to standard therapy for cutaneous and/or mucocutaneous fungal infection were treated with amphotericin B Gel. The amphotericin B Gel was applied on the affected area twice daily for 14 days in patients with cutaneous fungal infection and for 7 days in patients of mucocutaneous fungal infection. Response to the amphotericin B Gel treatment was monitored in the patients for up to 14 days and 28 days for mucocutaneous and cutaneous infection respectively.Results: Based on the stability studies, the recommended shelf life of amphotericin B gel is 24 months at 25°C. In vitro studies showed the release of ~90% amphotericin B within two hours and complete release within four hours. A total of 83 patients were assessed for cutaneous fungal infection where 39 patients were cured, 9 patients showed marked improvement, 26 patients showed moderate improvement and 9 patients showed failure after the treatment. For mucocutaneous fungal infection, 100% patients were cured at the end of the treatment. No serious adverse events were reported in patients during the study.Conclusion: Lipid based amphotericin B gel in patients with cutaneous and mucocutaneous fungal infections was found to be safe, tolerable and efficacious." @default.
• W2316656192 created "2016-06-24" @default.
• W2316656192 creator A5055853083 @default.
• W2316656192 date "2014-01-01" @default.
• W2316656192 modified "2023-09-25" @default.
• W2316656192 title "Topical Delivery of Lipid Based Amphotericin B Gel in the Treatment of Fungal Infection: A Clinical Efficacy, Safety and Tolerability Study in Patients" @default.
• W2316656192 cites W1450986477 @default.
• W2316656192 cites W1893349977 @default.
• W2316656192 cites W1969803231 @default.
• W2316656192 cites W1972082947 @default.
• W2316656192 cites W1999964163 @default.
• W2316656192 cites W2007409220 @default.
• W2316656192 cites W2011801278 @default.
• W2316656192 cites W2022322709 @default.
• W2316656192 cites W2028761028 @default.
• W2316656192 cites W2057769202 @default.
• W2316656192 cites W2064817138 @default.
• W2316656192 cites W2102264445 @default.
• W2316656192 cites W2141162588 @default.
• W2316656192 cites W2181470663 @default.
• W2316656192 doi "https://doi.org/10.4172/2155-9554.1000248" @default.
• W2316656192 hasPublicationYear "2014" @default.
• W2316656192 type Work @default.
• W2316656192 sameAs 2316656192 @default.
• W2316656192 citedByCount "2" @default.
• W2316656192 countsByYear W23166561922020 @default.
• W2316656192 countsByYear W23166561922022 @default.
• W2316656192 crossrefType "journal-article" @default.
• W2316656192 hasAuthorship W2316656192A5055853083 @default.
• W2316656192 hasConcept C157585117 @default.
• W2316656192 hasConcept C16005928 @default.
• W2316656192 hasConcept C177713679 @default.
• W2316656192 hasConcept C197934379 @default.
• W2316656192 hasConcept C2778375690 @default.
• W2316656192 hasConcept C2779548794 @default.
• W2316656192 hasConcept C2779629538 @default.
• W2316656192 hasConcept C3018359032 @default.
• W2316656192 hasConcept C60644358 @default.
• W2316656192 hasConcept C71924100 @default.
• W2316656192 hasConcept C86803240 @default.
• W2316656192 hasConcept C98274493 @default.
• W2316656192 hasConceptScore W2316656192C157585117 @default.
• W2316656192 hasConceptScore W2316656192C16005928 @default.
• W2316656192 hasConceptScore W2316656192C177713679 @default.
• W2316656192 hasConceptScore W2316656192C197934379 @default.
• W2316656192 hasConceptScore W2316656192C2778375690 @default.
• W2316656192 hasConceptScore W2316656192C2779548794 @default.
• W2316656192 hasConceptScore W2316656192C2779629538 @default.
• W2316656192 hasConceptScore W2316656192C3018359032 @default.
• W2316656192 hasConceptScore W2316656192C60644358 @default.
• W2316656192 hasConceptScore W2316656192C71924100 @default.
• W2316656192 hasConceptScore W2316656192C86803240 @default.
• W2316656192 hasConceptScore W2316656192C98274493 @default.
• W2316656192 hasIssue "06" @default.
• W2316656192 hasLocation W23166561921 @default.
• W2316656192 hasOpenAccess W2316656192 @default.
• W2316656192 hasPrimaryLocation W23166561921 @default.
• W2316656192 hasRelatedWork W1982653358 @default.
• W2316656192 hasRelatedWork W1999314602 @default.
• W2316656192 hasRelatedWork W2009695083 @default.
• W2316656192 hasRelatedWork W2088448469 @default.
• W2316656192 hasRelatedWork W2108988378 @default.
• W2316656192 hasRelatedWork W2566351228 @default.
• W2316656192 hasRelatedWork W2583665135 @default.
• W2316656192 hasRelatedWork W3023502736 @default.
• W2316656192 hasRelatedWork W3042350762 @default.
• W2316656192 hasRelatedWork W2016210988 @default.
• W2316656192 hasVolume "05" @default.
• W2316656192 isParatext "false" @default.
• W2316656192 isRetracted "false" @default.
• W2316656192 magId "2316656192" @default.
• W2316656192 workType "article" @default.