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- W2316661925 abstract "Enantio- and diastereodivergent approaches to pyrrolidines are described by using catalyst- and substrate-controlled reaction pathways. A concerted endo-selective [3 + 2]-cycloaddition pathway is developed for the reaction of methyl imino ester, whereas endo-pyrrolidines with an opposite absolute stereochemical outcome are prepared by using the stepwise reaction pathway of tert-butyl imino ester. The development of catalyst- and substrate-controlled stereodivergent approaches highlights the inherent substrate–catalyst interactions in the [3 + 2]-cycloaddition reactions of metalated azomethine ylides." @default.
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- W2316661925 date "2015-02-19" @default.
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- W2316661925 title "Brucine Diol–Copper-Catalyzed Asymmetric Synthesis of <i>endo</i>-Pyrrolidines: The Mechanistic Dichotomy of Imino Esters" @default.
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- W2316661925 doi "https://doi.org/10.1021/acs.orglett.5b00277" @default.
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