Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316663249> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2316663249 abstract "Objective: Although HER2 and ER pathways are predominant pathways altered in breast cancer, it is now well accepted that many other signaling pathways are also involved in the pathogenesis of breast cancer, especially in triple negative breast cancer. The understanding of these additional pathways may assist in identifying new therapeutic approaches for breast cancer. Methods: 13 invasive ductal carcinoma tissues and 5 benign breast tissues were analyzed for the mRNA expression level of 1243 cancer pathway-related genes using SmartChip (WaferGen, CA), a real-time PCR-base method. In addition, the levels of 154 cancer pathway-related proteins and phosphoproteins were measured using our innovative Protein Pathway Array. Results: Out of 1,243 mRNAs, 68.7% were detected in breast cancer and 73 mRNAs were statistically significant between benign and cancer tissues. Of these mRNAs, 105 only expressed in breast cancer tissues and 33 mRNAs only expressed in normal breast tissues. Out of 154 proteins and phosphoproteins, 39% were detected in cancer tissues and 50 proteins were significantly differentiated between tumor and normal tissues. Interestingly, only 3 genes (CDK6, Vimentin and SLUG) showed decrease of both protein and mRNA. Six proteins (BCL6, CCNE1, PCNA, PDK1, SRC and XIAP) showed differentially expressed between tumor and normal tissues but no differences were observed at mRNA levels. Analyses of mRNA and protein data using Ingenuity Pathway Analysis showed more 15 pathways were altered in breast cancers and 6 of them shared between mRNAs and proteins, including p53, IL17, HGF, NGF, PTEN and PI3K/AKT. Conclusion: There is a broad dysregulation of various pathways in breast cancer both at protein levels and mRNA levels. It is important to note that mRNA expression does not correlate with protein level, suggesting that different regulation mechanisms between proteins and mRNAs. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-05-19." @default.
- W2316663249 created "2016-06-24" @default.
- W2316663249 creator A5017482227 @default.
- W2316663249 creator A5027857029 @default.
- W2316663249 creator A5033186359 @default.
- W2316663249 creator A5046027057 @default.
- W2316663249 creator A5054386630 @default.
- W2316663249 creator A5069028088 @default.
- W2316663249 creator A5073339735 @default.
- W2316663249 date "2012-12-15" @default.
- W2316663249 modified "2023-09-26" @default.
- W2316663249 title "Abstract P2-05-19: Pathway-based analysis of breast cancer" @default.
- W2316663249 doi "https://doi.org/10.1158/0008-5472.sabcs12-p2-05-19" @default.
- W2316663249 hasPublicationYear "2012" @default.
- W2316663249 type Work @default.
- W2316663249 sameAs 2316663249 @default.
- W2316663249 citedByCount "0" @default.
- W2316663249 crossrefType "proceedings-article" @default.
- W2316663249 hasAuthorship W2316663249A5017482227 @default.
- W2316663249 hasAuthorship W2316663249A5027857029 @default.
- W2316663249 hasAuthorship W2316663249A5033186359 @default.
- W2316663249 hasAuthorship W2316663249A5046027057 @default.
- W2316663249 hasAuthorship W2316663249A5054386630 @default.
- W2316663249 hasAuthorship W2316663249A5069028088 @default.
- W2316663249 hasAuthorship W2316663249A5073339735 @default.
- W2316663249 hasConcept C104317684 @default.
- W2316663249 hasConcept C105580179 @default.
- W2316663249 hasConcept C121608353 @default.
- W2316663249 hasConcept C126322002 @default.
- W2316663249 hasConcept C147447768 @default.
- W2316663249 hasConcept C203014093 @default.
- W2316663249 hasConcept C204232928 @default.
- W2316663249 hasConcept C2775975398 @default.
- W2316663249 hasConcept C2777609662 @default.
- W2316663249 hasConcept C502942594 @default.
- W2316663249 hasConcept C530470458 @default.
- W2316663249 hasConcept C55493867 @default.
- W2316663249 hasConcept C62478195 @default.
- W2316663249 hasConcept C71924100 @default.
- W2316663249 hasConcept C86554907 @default.
- W2316663249 hasConcept C86803240 @default.
- W2316663249 hasConcept C95444343 @default.
- W2316663249 hasConceptScore W2316663249C104317684 @default.
- W2316663249 hasConceptScore W2316663249C105580179 @default.
- W2316663249 hasConceptScore W2316663249C121608353 @default.
- W2316663249 hasConceptScore W2316663249C126322002 @default.
- W2316663249 hasConceptScore W2316663249C147447768 @default.
- W2316663249 hasConceptScore W2316663249C203014093 @default.
- W2316663249 hasConceptScore W2316663249C204232928 @default.
- W2316663249 hasConceptScore W2316663249C2775975398 @default.
- W2316663249 hasConceptScore W2316663249C2777609662 @default.
- W2316663249 hasConceptScore W2316663249C502942594 @default.
- W2316663249 hasConceptScore W2316663249C530470458 @default.
- W2316663249 hasConceptScore W2316663249C55493867 @default.
- W2316663249 hasConceptScore W2316663249C62478195 @default.
- W2316663249 hasConceptScore W2316663249C71924100 @default.
- W2316663249 hasConceptScore W2316663249C86554907 @default.
- W2316663249 hasConceptScore W2316663249C86803240 @default.
- W2316663249 hasConceptScore W2316663249C95444343 @default.
- W2316663249 hasLocation W23166632491 @default.
- W2316663249 hasOpenAccess W2316663249 @default.
- W2316663249 hasPrimaryLocation W23166632491 @default.
- W2316663249 hasRelatedWork W2006960020 @default.
- W2316663249 hasRelatedWork W2022143863 @default.
- W2316663249 hasRelatedWork W2034065555 @default.
- W2316663249 hasRelatedWork W2045585997 @default.
- W2316663249 hasRelatedWork W2155677499 @default.
- W2316663249 hasRelatedWork W2159879760 @default.
- W2316663249 hasRelatedWork W2278441875 @default.
- W2316663249 hasRelatedWork W2325760039 @default.
- W2316663249 hasRelatedWork W2333362454 @default.
- W2316663249 hasRelatedWork W2461065768 @default.
- W2316663249 hasRelatedWork W2479207946 @default.
- W2316663249 hasRelatedWork W2556020554 @default.
- W2316663249 hasRelatedWork W2801115987 @default.
- W2316663249 hasRelatedWork W2936124731 @default.
- W2316663249 hasRelatedWork W2944768831 @default.
- W2316663249 hasRelatedWork W2978603976 @default.
- W2316663249 hasRelatedWork W2981123062 @default.
- W2316663249 hasRelatedWork W3006441749 @default.
- W2316663249 hasRelatedWork W3031366189 @default.
- W2316663249 hasRelatedWork W3037889263 @default.
- W2316663249 isParatext "false" @default.
- W2316663249 isRetracted "false" @default.
- W2316663249 magId "2316663249" @default.
- W2316663249 workType "article" @default.