FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316672215> ?p ?o ?g. }

• W2316672215 abstract "To explore the characteristics of changes in neutrophil gelatinase-associated lipocalcin (NGAL), kidney injury molecule-1 (KIM-1) and interleukin-18 (IL-18) in Phytolaccae Radix-induced kidney injury in rats and the significance of the combined detection.Wistar rats were divided into three groups: high and low dose (crude drug 40, 20 g x kg(-1) x d(-1)) Phytolaccae Radix decoction groups and the control group, and orally administrated with distilled water or equal volume of Phytolaccae Radix decoction for 35 consecutive days. Their blood and urine samples were collected on day 7, 14, 21, 28, 35,42. The anatomical analysis was conducted for each group. The contents of serum total protein (TP), albumin (ALB), blood urea nitrogen (BUN), creatinine (CR) and urinary TP and ALB were detected-by means of biochemical analyzer. The concentrations of urinary NGAL, KIM-1 and IL-18 were measured by enzyme-linked immunosorbent assay (ELISA). The morphological changes of renal pathology were observed by light or electron microscopy. The curve areas of various serum or urine indexes and the combined detection were compared by receiver operating characteristic curve (ROC curve).Rats were given Phytolaccae Radix decoction at the doses of 40, 20 g crude drug/kg daily for 35 consecutive days to induce kidney injury characterized by the degeneration of renal tubular epithelial cell and protein cast. The injury was partially reversible during the recovery period. Compared with the control group, the content of serum BUN, CR and urinary TP in each dose group mostly showed a downward trend. On day 21, the content of urinary ALB obviously increased till the end of administration. The contents of urinary NGAL, KIM-1 and IL-18 began increasing on day 7. Since day 14, high and low dose groups showed significant difference (P<0.01). The high dose group even showed notable changes during the recovery period. According to ROC analysis, the curve areas of NGAL, KIM-1 and IL-18 were 0.846, 0.837 and 0.863 (P <0.01), respectively, much higher than that of BUN and CR. The area of the combined detection was up to 0.947.Urinary NGAL, IL-18 and KIM-1 could forecast and indicate the occurrence and development of renal injury to some degree, and show higher sensitivity and site specificity. The combined detection could further improve the test efficiency." @default.
• W2316672215 created "2016-06-24" @default.
• W2316672215 creator A5023153444 @default.
• W2316672215 creator A5035335869 @default.
• W2316672215 creator A5048596983 @default.
• W2316672215 creator A5087434414 @default.
• W2316672215 date "2012-12-01" @default.
• W2316672215 modified "2023-09-26" @default.
• W2316672215 title "Characteristics of changes in urinary NGAL, KIM-1 and IL-18 in Phytolaccae Radix-induced renal injury in rats and significance of combined detection" @default.
• W2316672215 doi "https://doi.org/10.4268/cjcmm20122322" @default.
• W2316672215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23477150" @default.
• W2316672215 hasPublicationYear "2012" @default.
• W2316672215 type Work @default.
• W2316672215 sameAs 2316672215 @default.
• W2316672215 citedByCount "0" @default.
• W2316672215 crossrefType "journal-article" @default.
• W2316672215 hasAuthorship W2316672215A5023153444 @default.
• W2316672215 hasAuthorship W2316672215A5035335869 @default.
• W2316672215 hasAuthorship W2316672215A5048596983 @default.
• W2316672215 hasAuthorship W2316672215A5087434414 @default.
• W2316672215 hasConcept C126322002 @default.
• W2316672215 hasConcept C126894567 @default.
• W2316672215 hasConcept C134018914 @default.
• W2316672215 hasConcept C185592680 @default.
• W2316672215 hasConcept C190409667 @default.
• W2316672215 hasConcept C2778176769 @default.
• W2316672215 hasConcept C2779091547 @default.
• W2316672215 hasConcept C2780026642 @default.
• W2316672215 hasConcept C2780091579 @default.
• W2316672215 hasConcept C2780306776 @default.
• W2316672215 hasConcept C59822182 @default.
• W2316672215 hasConcept C71924100 @default.
• W2316672215 hasConcept C76318530 @default.
• W2316672215 hasConcept C77411442 @default.
• W2316672215 hasConcept C86803240 @default.
• W2316672215 hasConceptScore W2316672215C126322002 @default.
• W2316672215 hasConceptScore W2316672215C126894567 @default.
• W2316672215 hasConceptScore W2316672215C134018914 @default.
• W2316672215 hasConceptScore W2316672215C185592680 @default.
• W2316672215 hasConceptScore W2316672215C190409667 @default.
• W2316672215 hasConceptScore W2316672215C2778176769 @default.
• W2316672215 hasConceptScore W2316672215C2779091547 @default.
• W2316672215 hasConceptScore W2316672215C2780026642 @default.
• W2316672215 hasConceptScore W2316672215C2780091579 @default.
• W2316672215 hasConceptScore W2316672215C2780306776 @default.
• W2316672215 hasConceptScore W2316672215C59822182 @default.
• W2316672215 hasConceptScore W2316672215C71924100 @default.
• W2316672215 hasConceptScore W2316672215C76318530 @default.
• W2316672215 hasConceptScore W2316672215C77411442 @default.
• W2316672215 hasConceptScore W2316672215C86803240 @default.
• W2316672215 hasLocation W23166722151 @default.
• W2316672215 hasLocation W23166722152 @default.
• W2316672215 hasOpenAccess W2316672215 @default.
• W2316672215 hasPrimaryLocation W23166722151 @default.
• W2316672215 hasRelatedWork W1557215271 @default.
• W2316672215 hasRelatedWork W1975430824 @default.
• W2316672215 hasRelatedWork W2068979787 @default.
• W2316672215 hasRelatedWork W2258981636 @default.
• W2316672215 hasRelatedWork W2369552721 @default.
• W2316672215 hasRelatedWork W2371369831 @default.
• W2316672215 hasRelatedWork W2373343304 @default.
• W2316672215 hasRelatedWork W2377006731 @default.
• W2316672215 hasRelatedWork W2387422450 @default.
• W2316672215 hasRelatedWork W252453601 @default.
• W2316672215 isParatext "false" @default.
• W2316672215 isRetracted "false" @default.
• W2316672215 magId "2316672215" @default.
• W2316672215 workType "article" @default.