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- W2316707295 abstract "Objectives In preeclampsia (PE) an imbalance in the T helper 1 (Th1)/T helper 2 (Th2) cytokine balance has been proposed with a deviation toward the Th1 cytokine profile rather than a shift toward Th2 cell differentiation in normal pregnancy, while its reason has been not yet known. Recently, many reports from western countries and our reports in Japan have been concerned with the relationship between female fetus and PE. But, this mechanism of female preponderance in PE has not been defined. Methods After Institutional Review Board approval, we examined the effect of maternal status (age and body mass index [BMI]), fetal sex, fetal body weight, and placental weight on maternal Th1/Th2 cytokine balance in singleton cases of PE in Japan. The ratio of IFN γ /IL-4 in peripheral blood CD4+ T cells was determined using a flow cytometry in 62 PE patients sampled after the onset of PE. Analysis of covariance (ANCOVA) was used to investigate the relationship between feto-maternal conditions and maternal Th1/Th2 cytokine balance. Results The Th1/Th2 ratio was higher in mothers with higher BMI and a male fetus, as well as in mothers with lower BMI and a female fetus. Fetal sex had a significantly different effect on the relationship between Th1/Th2 ratio and BMI (P = 0.04). But fetal sex didn’t affect the Th1/Th2 ratio in relation to maternal age, fetal weight, and placental weight (P = 0.95, P = 0.83, P = 0.93, respectively). Conclusions The current study suggest that high-BMI women with a male fetus and low-BMI women with a female fetus tend to develop PE with Th1 cytokine predominance. These findings may help clarify the previous conflicting results about fetal sex as one of risk factors in the pathogenesis of PE. Disclosures A. Shiozaki: None. S. Suzuki: None. K. Naruse: None. S. Soeda: None. Y. Ono: None. A. Sameshima: None. N. Yoneda: None. M. Ito: None. S. Yoneda: None. H. Kobayashi: None. S. Saito: None." @default.
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- W2316707295 date "2015-01-01" @default.
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- W2316707295 doi "https://doi.org/10.1016/j.preghy.2014.10.199" @default.
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