Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316711782> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2316711782 abstract "Objective Mercury (Hg) is recognised as neurotoxin; nevertheless, the effect of prenatal mercury exposure on child behavior in fish eating population is still controversial. The benefit of nutrient element of fish may insufficient to explain it. Apolipoprotein (APOE) is a major protein transporter in brain, epsilon 4 (e4) allele is recognised with poorer neural repair function. We hypothesize that the APOE may modifier the effect of prenatal mercury exposure on child behaviour. Methods The present study is a prospective cohort study. There were 166 subjects recruited at delivery and followed up at age of two years. The level of prenatal mercury exposure is determined in cord blood and the genotype of APOE is analysis by the methods Restriction Fragment Length Polymorphism Analysis of PCR-Amplified Fragments (PCR-RFLP). The Child Behavior Checklists version 1.5/5, a parent rating scale, is used to determine the child’s behaviour. Results The adverse effect is found in e4 carriers whose cord blood Hg level is greater than 12ug/l. After controlling for the potential confounding factors, the total scale of internalising behavior (b = 8.4) and all symptoms of internalising problems is found statistically significant higher in this group. The symptoms and beta coefficients are emotional problem (b = 2.6), anxiety/depression (b = 2.4), somatic complaints (b = 1.68) and withdrawn (b = 1.7). In additional to internalising behaviour, the item of other problem (b = 6.7) from externalising behaviour and the total scale of CBCL (b = 20.7) are also found statistically significant higher in the group that e4 carriers with greater cord blood Hg. Conclusion APOE gene modifies the effect of prenatal mercury exposure on neurobehaviour. The different frequency of gene susceptible across populations may be a reason of the controversial finding in previous study. The impact of genetic susceptibility should be considered in future study." @default.
- W2316711782 created "2016-06-24" @default.
- W2316711782 creator A5000310523 @default.
- W2316711782 creator A5021473376 @default.
- W2316711782 creator A5036457690 @default.
- W2316711782 creator A5068607867 @default.
- W2316711782 creator A5069646901 @default.
- W2316711782 creator A5076324015 @default.
- W2316711782 date "2013-09-01" @default.
- W2316711782 modified "2023-09-23" @default.
- W2316711782 title "227 Cord Blood Mercury, APOE and Child’s Behaviour" @default.
- W2316711782 doi "https://doi.org/10.1136/oemed-2013-101717.227" @default.
- W2316711782 hasPublicationYear "2013" @default.
- W2316711782 type Work @default.
- W2316711782 sameAs 2316711782 @default.
- W2316711782 citedByCount "0" @default.
- W2316711782 crossrefType "journal-article" @default.
- W2316711782 hasAuthorship W2316711782A5000310523 @default.
- W2316711782 hasAuthorship W2316711782A5021473376 @default.
- W2316711782 hasAuthorship W2316711782A5036457690 @default.
- W2316711782 hasAuthorship W2316711782A5068607867 @default.
- W2316711782 hasAuthorship W2316711782A5069646901 @default.
- W2316711782 hasAuthorship W2316711782A5076324015 @default.
- W2316711782 hasBestOaLocation W23167117821 @default.
- W2316711782 hasConcept C118552586 @default.
- W2316711782 hasConcept C126322002 @default.
- W2316711782 hasConcept C2780914630 @default.
- W2316711782 hasConcept C2908647359 @default.
- W2316711782 hasConcept C558461103 @default.
- W2316711782 hasConcept C71924100 @default.
- W2316711782 hasConcept C72563966 @default.
- W2316711782 hasConcept C99454951 @default.
- W2316711782 hasConceptScore W2316711782C118552586 @default.
- W2316711782 hasConceptScore W2316711782C126322002 @default.
- W2316711782 hasConceptScore W2316711782C2780914630 @default.
- W2316711782 hasConceptScore W2316711782C2908647359 @default.
- W2316711782 hasConceptScore W2316711782C558461103 @default.
- W2316711782 hasConceptScore W2316711782C71924100 @default.
- W2316711782 hasConceptScore W2316711782C72563966 @default.
- W2316711782 hasConceptScore W2316711782C99454951 @default.
- W2316711782 hasLocation W23167117821 @default.
- W2316711782 hasOpenAccess W2316711782 @default.
- W2316711782 hasPrimaryLocation W23167117821 @default.
- W2316711782 hasRelatedWork W1475047071 @default.
- W2316711782 hasRelatedWork W1928921955 @default.
- W2316711782 hasRelatedWork W1981680932 @default.
- W2316711782 hasRelatedWork W1991204205 @default.
- W2316711782 hasRelatedWork W1999541346 @default.
- W2316711782 hasRelatedWork W2006932480 @default.
- W2316711782 hasRelatedWork W2049179315 @default.
- W2316711782 hasRelatedWork W2059596442 @default.
- W2316711782 hasRelatedWork W2084908102 @default.
- W2316711782 hasRelatedWork W2351099038 @default.
- W2316711782 hasRelatedWork W2501352815 @default.
- W2316711782 hasRelatedWork W2503477570 @default.
- W2316711782 hasRelatedWork W2899701947 @default.
- W2316711782 hasRelatedWork W2906056278 @default.
- W2316711782 hasRelatedWork W2912754916 @default.
- W2316711782 hasRelatedWork W2915921545 @default.
- W2316711782 hasRelatedWork W2942265148 @default.
- W2316711782 hasRelatedWork W2947101685 @default.
- W2316711782 hasRelatedWork W2953250340 @default.
- W2316711782 hasRelatedWork W3186937797 @default.
- W2316711782 isParatext "false" @default.
- W2316711782 isRetracted "false" @default.
- W2316711782 magId "2316711782" @default.
- W2316711782 workType "article" @default.