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• W2316731718 abstract "Event Abstract Back to Event Greater number of activated T cells and enlarged germinal centers in the spleen of bovine FcRn transgenic mice in the background of the enhanced immune response Zita Schneider1, Attila Végh1, 2, Judit Cervenak2, Péter Balogh3 and Imre Kacskovics1, 2* 1 Eötvös Loránd University, Department of Immunology, Hungary 2 ImmunoGenes Kft., Hungary 3 University of Pécs, Department of Immunology and Biotechnology, Hungary The neonatal Fc receptor (FcRn) plays key roles in IgG and albumin homeostasis, maternal IgG transports and antigen presentation in case of IgG-opsonized antigens. We have previously shown that bovine FcRn (bFcRn) overexpression in transgenic (Tg) mice resulted in mounting robust humoral response against weakly immunogenic antigens and improving hybridoma production efficiency without any sign of autoimmunity. Further studies showed strong expression of bFcRn in peritoneal macrophages and bone marrow-derived dendritic cells (BMDCs) as well as indicated significantly improved T cell proliferation induced by BMDCs after IgG-ovalbumin immune complex phagocytosis in vitro. To gain further insights of this enhanced antibody response, we immunized mice with ovalbumin and found at least twice as many activated, antigen-specific T cells in the spleen of bFcRn Tg mice compared with wild-type (wt) mice. Furthermore, germinal centers of the immunized bFcRn Tg mice were found to be double the size of those observed in wt controls after 3 days of booster injection, indicating significantly improved germinal center reactions in case of Tg mice. To identify cell populations expressing bFcRn, we developed bFcRn-specific monoclonal antibody that does not cross react with mouse FcRn. We detected strong bFcRn expression in macrophages of splenic marginal zone, but also found bFcRn positive cells in the T cell zone and in the red pulp, possibly dendritic cells and red pulp macrophages, respectively. These new findings provide better explanations for the augmented humoral immune response in bFcRn transgenic mice. Supported by grant K101364 from Hungarian Scientific Research Fund. Keywords: neonatal Fc receptor, Transgenic mice, Germinal Center, immune response, Monoclonal antibody Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune receptors and signaling Citation: Schneider Z, Végh A, Cervenak J, Balogh P and Kacskovics I (2013). Greater number of activated T cells and enlarged germinal centers in the spleen of bovine FcRn transgenic mice in the background of the enhanced immune response. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.01080 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Jul 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Imre Kacskovics, Eötvös Loránd University, Department of Immunology, Budapest, Hungary, imre.kacskovics@immunogenes.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Zita Schneider Attila Végh Judit Cervenak Péter Balogh Imre Kacskovics Google Zita Schneider Attila Végh Judit Cervenak Péter Balogh Imre Kacskovics Google Scholar Zita Schneider Attila Végh Judit Cervenak Péter Balogh Imre Kacskovics PubMed Zita Schneider Attila Végh Judit Cervenak Péter Balogh Imre Kacskovics Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2316731718 title "Greater number of activated T cells and enlarged germinal centers in the spleen of bovine FcRn transgenic mice in the background of the enhanced immune response" @default.
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