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• W2316746946 startingPage "1478" @default.
• W2316746946 abstract "Transport of surface active anesthetic drugs through silicone hydrogel contact lenses containing nanosized vitamin E aggregates is explored for achieving extended anesthetics delivery. Commercial silicone hydrogel contact lenses release most ophthalmic drugs including local anesthetics for only a few hours, which is not adequate. Here we focus on creating dispersion of highly hydrophobic vitamin E aggregates in the lenses as barriers for drug diffusion for increasing the release durations. This approach has been shown previously to be successful in extending the release durations for some common hydrophilic ophthalmic drugs. The topical anesthetic drugs considered here (lidocaine, bupivacaine, and tetracaine) are hydrophilic at physiologic pH due to the charge, and so these cannot partition into the vitamin E barriers. However, these surface active drug molecules adsorb on the surface of the vitamin E barriers and diffuse along the surface, leading to only a small decrease in the effective diffusivity compared to non-surface-active hydrophilic drugs. The drug adsorption can be described by the Langmuir isotherm, and measurements of surface coverage of the drugs on the vitamin E provide an estimate of the available surface area of vitamin E, which can then be utilized to estimate the size of the aggregates. A diffusion controlled transport model that includes surface diffusion along the vitamin E aggregates and diffusion in the gel fit the transport data well. In conclusion, the vitamin E loaded silicone contact lens can provide continuous anesthetics release for about 1–7 days, depending on the method of drug loading in the lenses, and thus could be very useful for postoperative pain control after corneal surgery such as the photorefractive keratectomy (PRK) procedure for vision correction." @default.
• W2316746946 created "2016-06-24" @default.
• W2316746946 creator A5029555815 @default.
• W2316746946 creator A5032289092 @default.
• W2316746946 creator A5064866113 @default.
• W2316746946 date "2011-12-22" @default.
• W2316746946 modified "2023-09-25" @default.
• W2316746946 title "Transport of Topical Anesthetics in Vitamin E Loaded Silicone Hydrogel Contact Lenses" @default.
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• W2316746946 doi "https://doi.org/10.1021/la203606z" @default.
• W2316746946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22149062" @default.
• W2316746946 hasPublicationYear "2011" @default.
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