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- W2316751514 abstract "Therapeutic implications of marine omega-3 highly unsaturated fatty acids (HUFA) in cardiovascular disease are still discussed controversially. Several clinical trials report divergent findings and thus leave ambiguity on the meaning of oral omega-3 therapy. Potential prognostic indications of HUFA treatment have been predominantly studied in coronary artery disease, sudden cardiac death, ventricular arrhythmias, atrial fibrillation and heart failure of various origin. It is suspected that increased ventricular wall stress is crucially involved in the prognosis of heart failure. Increased wall stress and an unfavorable myocardial remodeling is associated with an increased risk of arrhythmias by stretch-activated membrane ion channels. Integration of HUFA into the microenvironment of cardiomyocyte ion channels lead to allosteric changes and increase the electrical stability. Increased ventricular wall stress appears to be involved in the local myocardial as well as in the hepatic fatty acid metabolism, i.e. a cardio-hepatic syndrome. Influences of an altered endogenous HUFA metabolism and an inverse shift of the fatty acid profile was underrated in the past. A better understanding of these interacting endogenous mechanisms appears to be required for interpreting the findings of recent experimental and clinical studies. The present article critically reviews major studies on basic pathophysiological mechanisms and treatment effects in clinical trials." @default.
- W2316751514 created "2016-06-24" @default.
- W2316751514 creator A5026619386 @default.
- W2316751514 creator A5036967952 @default.
- W2316751514 date "2016-07-01" @default.
- W2316751514 modified "2023-09-24" @default.
- W2316751514 title "Marine omega-3 highly unsaturated fatty acids: From mechanisms to clinical implications in heart failure and arrhythmias" @default.
- W2316751514 cites W1525552603 @default.
- W2316751514 cites W1527027162 @default.
- W2316751514 cites W1550716889 @default.
- W2316751514 cites W1560062315 @default.
- W2316751514 cites W1819207053 @default.
- W2316751514 cites W1863611356 @default.
- W2316751514 cites W1885774346 @default.
- W2316751514 cites W1901320394 @default.
- W2316751514 cites W1968786896 @default.
- W2316751514 cites W1971091197 @default.
- W2316751514 cites W1972246703 @default.
- W2316751514 cites W1973154574 @default.
- W2316751514 cites W1974029961 @default.
- W2316751514 cites W1974550968 @default.
- W2316751514 cites W1976721331 @default.
- W2316751514 cites W1976885664 @default.
- W2316751514 cites W1980857378 @default.
- W2316751514 cites W1983531379 @default.
- W2316751514 cites W1985761375 @default.
- W2316751514 cites W1986222699 @default.
- W2316751514 cites W1987045148 @default.
- W2316751514 cites W1991347929 @default.
- W2316751514 cites W1992687418 @default.
- W2316751514 cites W1997601961 @default.
- W2316751514 cites W2000913816 @default.
- W2316751514 cites W2001344835 @default.
- W2316751514 cites W2002313185 @default.
- W2316751514 cites W2002750215 @default.
- W2316751514 cites W2005594380 @default.
- W2316751514 cites W2006556786 @default.
- W2316751514 cites W2011218750 @default.
- W2316751514 cites W2012216316 @default.
- W2316751514 cites W2012332938 @default.
- W2316751514 cites W2012777696 @default.
- W2316751514 cites W2014226775 @default.
- W2316751514 cites W2020223480 @default.
- W2316751514 cites W2021339583 @default.
- W2316751514 cites W2026310866 @default.
- W2316751514 cites W2028257135 @default.
- W2316751514 cites W2030846416 @default.
- W2316751514 cites W2033283286 @default.
- W2316751514 cites W2034492390 @default.
- W2316751514 cites W2034696183 @default.
- W2316751514 cites W2039611770 @default.
- W2316751514 cites W2040837322 @default.
- W2316751514 cites W2041752824 @default.
- W2316751514 cites W2042411759 @default.
- W2316751514 cites W2045645934 @default.
- W2316751514 cites W2047173819 @default.
- W2316751514 cites W2048585401 @default.
- W2316751514 cites W2050708996 @default.
- W2316751514 cites W2051648756 @default.
- W2316751514 cites W2053388585 @default.
- W2316751514 cites W2054863456 @default.
- W2316751514 cites W2055143941 @default.
- W2316751514 cites W2055191929 @default.
- W2316751514 cites W2055911032 @default.
- W2316751514 cites W2056061902 @default.
- W2316751514 cites W2056239457 @default.
- W2316751514 cites W2057877030 @default.
- W2316751514 cites W2062573536 @default.
- W2316751514 cites W2062930869 @default.
- W2316751514 cites W2065740462 @default.
- W2316751514 cites W2065830303 @default.
- W2316751514 cites W2071077621 @default.
- W2316751514 cites W2071544160 @default.
- W2316751514 cites W2071755201 @default.
- W2316751514 cites W2077372396 @default.
- W2316751514 cites W2078472811 @default.
- W2316751514 cites W2080543940 @default.
- W2316751514 cites W2080621715 @default.
- W2316751514 cites W2080915708 @default.
- W2316751514 cites W2081245592 @default.
- W2316751514 cites W2081326812 @default.
- W2316751514 cites W2083693664 @default.
- W2316751514 cites W2084789998 @default.
- W2316751514 cites W2091593865 @default.
- W2316751514 cites W2093590196 @default.
- W2316751514 cites W2094522836 @default.
- W2316751514 cites W2095036821 @default.
- W2316751514 cites W2099749457 @default.
- W2316751514 cites W2099831545 @default.
- W2316751514 cites W2099859189 @default.
- W2316751514 cites W2104357833 @default.
- W2316751514 cites W2104680689 @default.
- W2316751514 cites W2109225320 @default.
- W2316751514 cites W2112229905 @default.
- W2316751514 cites W2115163080 @default.
- W2316751514 cites W2121137886 @default.
- W2316751514 cites W2122068440 @default.
- W2316751514 cites W2123694602 @default.