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- W2316793025 abstract "Malignant fibrous histiocytoma (MFH), which has been clarified in a recent years, commonly arises in the soft tissue of the adult extremities, but rarely in the lung. Here an operated case of primary MFH of the lung is reported. An 80-year-old man visited with the chief complaint of cough. Biopsy revealed no malignant findings, but imaging techniques offered a suspicion of adenocarcinoma in the right lobe. Right upper lobectomy with regional lymph node dissection was carried out. The tumor was located in the S2 area with pleural indentation. In dissected mediastinal lymph nodes, metastatic tumor cells were observed. Light microscopic findings showed predominantly mixed cells of both histiocytic and fibroblastic cells with a storiform pattern. Electron microscopic findings showed multinucleated giant histiocytic cells. The fibroblastic cells also presented with moderately prominent rough endoplasmic reticulum. Immunohistochemical findings by PAP method were as follows: staining for α-1-antitrypsin, α-1-antichmyotrypsin, lysozyme and ferritin were all positively stained, whereas staining for CEA, keratin, secretary component, epithelial membrane antigen, vimentin, actin, myoglobin and factor were not stained. From the above-mentioned histological findings, we diagnosed this lung tumor as primary malignant fibrous histiocytoma of the lung. A review of the 35 cases in the literature indicated: Including this case, the patient ranged in age 12 to 80 years old (median of 57.8 years). Two patients survived for 5 and 10 years, respectively and the median survival period was 1 year and 6 months. Twenty eight cases had surgical therapy: lobectomy in 20 (80%), pneumonecotmy in 4 (14.2%) and partial resection in 4 cases (14.2%). Distant metastasis from lung MFH occurred in 18 cases (50%) in which brain metastasis in 8 cases (44.4%) was most frequently observed. These findings suggested poor prognosis of MFH arising primarily in the lung." @default.
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- W2316793025 date "1991-01-01" @default.
- W2316793025 modified "2023-10-04" @default.
- W2316793025 title "AN OPERATED CASE OF PRIMARY MALIGNANT FIBROUS HISTIOCYTOMA OF THE LUNG" @default.
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- W2316793025 doi "https://doi.org/10.3919/ringe1963.52.2636" @default.
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