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- W2316800036 abstract "Purpose: This study9s purpose was to evaluate the clinical utility of breast cancer intrinsic subtypes in the prediction of pathological complete response (pCR) in a cohort of breast cancer patients receiving primary systemic chemotherapy. Patients and Methods: Patients with stage II/III breast cancer received 4 cycles of XT (capecitabine 1650 mg/m 2 on days 1-14 and docetaxel 60 mg/m 2 on day 8 every 3 weeks), followed by 4 cycles of FEC (fluorouracil 500 mg/m 2 , epirubicin 90 mg/m 2 , cyclophosphamide 500 mg/m 2 on day 1 every 3 weeks). Immunohistochemical analysis of estrogen receptor (ER), progesterone receptor (PgR), HER2, epidermal growth factor receptor (EGFR), cytokeratin (ck) 5/6, and Ki67 was performed in core needle biopsy samples at baseline. Tumors were classified as luminal A (ER+ and/or PgR+, and Ki67 Conclusions: Our data indicate that breast cancer subtypes are useful predictive biomarkers of pCR in breast cancer patients treated with primary systemic chemotherapy. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P2-09-35." @default.
- W2316800036 created "2016-06-24" @default.
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- W2316800036 date "2010-12-15" @default.
- W2316800036 modified "2023-09-25" @default.
- W2316800036 title "Abstract P2-09-35: Differential Pathologic Response from Primary Systemic Chemotherapy across Breast Cancer Intrinsic Subtypes" @default.
- W2316800036 doi "https://doi.org/10.1158/0008-5472.sabcs10-p2-09-35" @default.
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