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- W2316804004 abstract "In this study, hyaluronic acid (HA)/poly(lactic-co-glycolic acid, PLGA) core/shell fiber meshes loaded with epigallocatechin-3-O-gallate (EGCG) (HA/PLGA-E) for application to tissue engineering scaffolds for skin regeneration were prepared via coaxial electrospinning. Physicochemical properties of HA/PLGA-E core/shell fiber meshes were characterized by SEM, Raman spectroscopy, contact angle, EGCG release profiling and in vitro degradation. Biomechanical properties of HA/PLGA-E meshes were also investigated by a tensile strength test. SEM images showed that HA/PLGA-E fiber meshes had a three-dimensional interconnected pore structure with an average fiber diameter of about 1270 nm. Raman spectra revealed that EGCG was uniformly dispersed in the PLGA shell of meshes. HA/PLGA-E meshes showed sustained EGCG release patterns by controlled diffusion and PLGA degradation over 4 weeks. EGCG loading did not adversely affect the tensile strength and elastic modulus of HA/PLGA meshes, while increased their hydrophilicity and surface energy. Attachment of human dermal fibroblasts on HA/PLGA-E meshes was appreciably increased and their proliferation was steadily retained during the culture period. These results suggest that HA/PLGA-E core/shell fiber meshes can be potentially used as scaffolds supporting skin regeneration." @default.
- W2316804004 created "2016-06-24" @default.
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- W2316804004 date "2014-11-01" @default.
- W2316804004 modified "2023-09-25" @default.
- W2316804004 title "Hyaluronic Acid/Poly(lactic-<I>co</I>-glycolic acid) Core/Shell Fiber Meshes Loaded with Epigallocatechin-3-<I>O</I>-Gallate as Skin Tissue Engineering Scaffolds" @default.
- W2316804004 doi "https://doi.org/10.1166/jnn.2014.9922" @default.
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