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- W2316842100 abstract "Since detergent-resistant lipid rafts play important roles in multidrug resistance (MDR), their comprehensive proteomics could provide new insights to understand the underlying molecular mechanism of MDR in cancer cells. In the present work, lipid rafts were isolated from MCF-7 and adriamycin-resistant MCF-7/ADR cells and their proteomes were analyzed by label-free quantitative proteomics. Polymerase I and transcript release factor (PTRF)/cavin-1 was measured to be upregulated along with multidrug-resistant P-glycoprotein, caveolin-1, and serum deprivation protein response/cavin-2 in the lipid rafts of MCF-7/ADR cells. PTRF knockdown led to reduction in the amount of lipid rafts on the surface of MCF7/ADR cells as determined by cellular staining with lipid raft-specific dyes such as S-laurdan2 and FITC-conjugated cholera toxin B. PTRF knockdown also reduced MDR in MCF-7/ADR cells. These data indicate that PTRF is necessary for MDR in cancer cells via the fortification of lipid rafts." @default.
- W2316842100 created "2016-06-24" @default.
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- W2316842100 date "2013-01-04" @default.
- W2316842100 modified "2023-09-23" @default.
- W2316842100 title "PTRF/Cavin-1 is Essential for Multidrug Resistance in Cancer Cells" @default.
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- W2316842100 cites W2001265443 @default.
- W2316842100 cites W2003414227 @default.
- W2316842100 cites W2005631145 @default.
- W2316842100 cites W2008225995 @default.
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- W2316842100 doi "https://doi.org/10.1021/pr300651m" @default.
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