FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316866275> ?p ?o ?g. }

• W2316866275 endingPage "177" @default.
• W2316866275 startingPage "173" @default.
• W2316866275 abstract "Wistar–Kyoto (WKY) rats, but not spontaneously hypertensive rats (SHRs), are insensitive to the acute hypolocomotor and anxiogenic effects of the selective serotonin reuptake inhibitors (SSRIs), fluoxetine and citalopram, in elevated plus-maze tests. Several observations suggest that these strain-dependent effects involve postsynaptic serotonin (5-HT) receptors. In keeping with the recent finding that citalopram-elicited anxiety in Sprague–Dawley rats, as measured in the social interaction test, involves 5-HT2C receptor stimulation, we tested the hypothesis that this receptor is prone to subsensitivity in WKY rats, compared to SHRs. Thus, we first examined the acute behavioural effects of the 5-HT2B/2C receptor agonist, mCPP, in SHRs and WKY rats exposed to an elevated plus-maze; in addition, because WKY rats display anxiety and hypolocomotion, compared to SHRs, we next used the 5-HT2B/2C receptor antagonist, SB-206553, to test whether 5-HT2C receptors are tonically active in WKY rats. The results confirmed that WKY rats and SHRs differ in locomotor activity and anxiety-related behaviours, and showed that pretreatment with mCPP decreased locomotion in both strains. In contrast, the strains differed with respect to mCPP-elicited anxiety, as WKY rats were sensitive to the lowest dose of mCPP, while only the highest dose increased anxiety in SHRs. Finally, elevated plus-maze behaviours of SHRs and WKY rats were found to be insensitive to SB-206553 pretreatment. This study therefore suggests that 5-HT2C receptors (at least those which mediate mCPP-induced hypolocomotion and anxiety) are neither desensitized nor tonically active in WKY rats." @default.
• W2316866275 created "2016-06-24" @default.
• W2316866275 creator A5005300801 @default.
• W2316866275 creator A5015707424 @default.
• W2316866275 creator A5045500471 @default.
• W2316866275 date "2003-03-01" @default.
• W2316866275 modified "2023-10-16" @default.
• W2316866275 title "Wistar–Kyoto rats are sensitive to the hypolocomotor and anxiogenic effects of mCPP" @default.
• W2316866275 cites W1964289699 @default.
• W2316866275 cites W1968638036 @default.
• W2316866275 cites W1976152983 @default.
• W2316866275 cites W2008197220 @default.
• W2316866275 cites W2018286553 @default.
• W2316866275 cites W2024551842 @default.
• W2316866275 cites W2037277347 @default.
• W2316866275 cites W2038620688 @default.
• W2316866275 cites W2038647013 @default.
• W2316866275 cites W2044069216 @default.
• W2316866275 cites W2044716658 @default.
• W2316866275 cites W2051459893 @default.
• W2316866275 cites W2055096975 @default.
• W2316866275 cites W2058242946 @default.
• W2316866275 cites W2058878434 @default.
• W2316866275 cites W2059014690 @default.
• W2316866275 cites W2064307164 @default.
• W2316866275 cites W2089210700 @default.
• W2316866275 cites W2091715004 @default.
• W2316866275 cites W2095131733 @default.
• W2316866275 cites W2095133395 @default.
• W2316866275 cites W2097477666 @default.
• W2316866275 cites W2155773280 @default.
• W2316866275 doi "https://doi.org/10.1097/00008877-200303000-00010" @default.
• W2316866275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12658079" @default.
• W2316866275 hasPublicationYear "2003" @default.
• W2316866275 type Work @default.
• W2316866275 sameAs 2316866275 @default.
• W2316866275 citedByCount "13" @default.
• W2316866275 countsByYear W23168662752012 @default.
• W2316866275 countsByYear W23168662752014 @default.
• W2316866275 countsByYear W23168662752016 @default.
• W2316866275 countsByYear W23168662752017 @default.
• W2316866275 countsByYear W23168662752018 @default.
• W2316866275 countsByYear W23168662752022 @default.
• W2316866275 crossrefType "journal-article" @default.
• W2316866275 hasAuthorship W2316866275A5005300801 @default.
• W2316866275 hasAuthorship W2316866275A5015707424 @default.
• W2316866275 hasAuthorship W2316866275A5045500471 @default.
• W2316866275 hasConcept C118552586 @default.
• W2316866275 hasConcept C126322002 @default.
• W2316866275 hasConcept C134018914 @default.
• W2316866275 hasConcept C15744967 @default.
• W2316866275 hasConcept C170493617 @default.
• W2316866275 hasConcept C173586616 @default.
• W2316866275 hasConcept C185592680 @default.
• W2316866275 hasConcept C205044023 @default.
• W2316866275 hasConcept C24998067 @default.
• W2316866275 hasConcept C2775864247 @default.
• W2316866275 hasConcept C2776134451 @default.
• W2316866275 hasConcept C2776885963 @default.
• W2316866275 hasConcept C2777490545 @default.
• W2316866275 hasConcept C2777765862 @default.
• W2316866275 hasConcept C2778122271 @default.
• W2316866275 hasConcept C2778938600 @default.
• W2316866275 hasConcept C53910766 @default.
• W2316866275 hasConcept C558461103 @default.
• W2316866275 hasConcept C71924100 @default.
• W2316866275 hasConcept C98274493 @default.
• W2316866275 hasConceptScore W2316866275C118552586 @default.
• W2316866275 hasConceptScore W2316866275C126322002 @default.
• W2316866275 hasConceptScore W2316866275C134018914 @default.
• W2316866275 hasConceptScore W2316866275C15744967 @default.
• W2316866275 hasConceptScore W2316866275C170493617 @default.
• W2316866275 hasConceptScore W2316866275C173586616 @default.
• W2316866275 hasConceptScore W2316866275C185592680 @default.
• W2316866275 hasConceptScore W2316866275C205044023 @default.
• W2316866275 hasConceptScore W2316866275C24998067 @default.
• W2316866275 hasConceptScore W2316866275C2775864247 @default.
• W2316866275 hasConceptScore W2316866275C2776134451 @default.
• W2316866275 hasConceptScore W2316866275C2776885963 @default.
• W2316866275 hasConceptScore W2316866275C2777490545 @default.
• W2316866275 hasConceptScore W2316866275C2777765862 @default.
• W2316866275 hasConceptScore W2316866275C2778122271 @default.
• W2316866275 hasConceptScore W2316866275C2778938600 @default.
• W2316866275 hasConceptScore W2316866275C53910766 @default.
• W2316866275 hasConceptScore W2316866275C558461103 @default.
• W2316866275 hasConceptScore W2316866275C71924100 @default.
• W2316866275 hasConceptScore W2316866275C98274493 @default.
• W2316866275 hasIssue "2" @default.
• W2316866275 hasLocation W23168662751 @default.
• W2316866275 hasLocation W23168662752 @default.
• W2316866275 hasLocation W23168662753 @default.
• W2316866275 hasOpenAccess W2316866275 @default.
• W2316866275 hasPrimaryLocation W23168662751 @default.
• W2316866275 hasRelatedWork W1977917237 @default.
• W2316866275 hasRelatedWork W2009606758 @default.
• W2316866275 hasRelatedWork W2023567520 @default.
• W2316866275 hasRelatedWork W2023748980 @default.
• W2316866275 hasRelatedWork W2072023643 @default.

• next