FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316872222> ?p ?o ?g. }

• W2316872222 endingPage "605" @default.
• W2316872222 startingPage "597" @default.
• W2316872222 abstract "A novel and versatile family of enzymatically and reductively degradable α-amino acid-based poly(ester amide)s (SS-PEAs) were developed from solution polycondensation of disulfide-containing di-p-toluenesulfonic acid salts of bis-l-phenylalanine diesters (SS-Phe-2TsOH) with di-p-nitrophenyl adipate (NA) in N,N-dimethylformamide (DMF). SS-PEAs with Mn ranging from 16.6 to 23.6 kg/mol were obtained, depending on NA/SS-Phe-2TsOH molar ratios. The chemical structures of SS-PEAs were confirmed by 1H NMR and FTIR spectra. Thermal analyses showed that the obtained SS-PEAs were amorphous with a glass transition temperature (Tg) in the range of 35.2–39.5 °C. The in vitro degradation studies of SS-PEA films revealed that SS-PEAs underwent surface erosion in the presence of 0.1 mg/mL α-chymotrypsin and bulk degradation under a reductive environment containing 10 mM dithiothreitol (DTT). The preliminary cell culture studies displayed that SS-PEA films could well support adhesion and proliferation of L929 fibroblast cells, indicating that SS-PEAs have excellent cell compatibility. The nanoparticles prepared from SS-PEA with PVA as a surfactant had an average size of 167 nm in phosphate buffer (PB, 10 mM, pH 7.4). SS-PEA nanoparticles while stable under physiological environment undergo rapid disintegration under an enzymatic or reductive condition. The in vitro drug release studies showed that DOX release was accelerated in the presence of 0.1 mg/mL α-chymotrypsin or 10 mM DTT. Confocal microscopy observation displayed that SS-PEA nanoparticles effectively transported DOX into both drug-sensitive and -resistant MCF-7 cells. MTT assays revealed that DOX-loaded SS-PEA nanoparticles had a high antitumor activity approaching that of free DOX in drug-sensitive MCF-7 cells, while more than 10 times higher than free DOX in drug-resistant MCF-7/ADR cells. These enzymatically and reductively degradable α-amino acid-based poly(ester amide)s have provided an appealing platform for biomedical technology in particular controlled drug delivery applications." @default.
• W2316872222 created "2016-06-24" @default.
• W2316872222 creator A5011696248 @default.
• W2316872222 creator A5024490292 @default.
• W2316872222 creator A5026189929 @default.
• W2316872222 creator A5039037778 @default.
• W2316872222 creator A5058784587 @default.
• W2316872222 creator A5072931528 @default.
• W2316872222 creator A5077781605 @default.
• W2316872222 creator A5081367381 @default.
• W2316872222 date "2015-01-17" @default.
• W2316872222 modified "2023-10-18" @default.
• W2316872222 title "Enzymatically and Reductively Degradable α-Amino Acid-Based Poly(ester amide)s: Synthesis, Cell Compatibility, and Intracellular Anticancer Drug Delivery" @default.
• W2316872222 cites W1968660655 @default.
• W2316872222 cites W1971455130 @default.
• W2316872222 cites W1971512869 @default.
• W2316872222 cites W1973157007 @default.
• W2316872222 cites W1977176966 @default.
• W2316872222 cites W1977914585 @default.
• W2316872222 cites W1980426710 @default.
• W2316872222 cites W1989558185 @default.
• W2316872222 cites W1990136133 @default.
• W2316872222 cites W1991564299 @default.
• W2316872222 cites W1995939094 @default.
• W2316872222 cites W2005427187 @default.
• W2316872222 cites W2010791599 @default.
• W2316872222 cites W2011319610 @default.
• W2316872222 cites W2017315930 @default.
• W2316872222 cites W2025035473 @default.
• W2316872222 cites W2027432937 @default.
• W2316872222 cites W2029039324 @default.
• W2316872222 cites W2033281188 @default.
• W2316872222 cites W2035882594 @default.
• W2316872222 cites W2041951047 @default.
• W2316872222 cites W2042619042 @default.
• W2316872222 cites W2046297549 @default.
• W2316872222 cites W2046542140 @default.
• W2316872222 cites W2048069206 @default.
• W2316872222 cites W2049657544 @default.
• W2316872222 cites W2054310958 @default.
• W2316872222 cites W2057846324 @default.
• W2316872222 cites W2063891273 @default.
• W2316872222 cites W2066061791 @default.
• W2316872222 cites W2071726528 @default.
• W2316872222 cites W2079038224 @default.
• W2316872222 cites W2079195108 @default.
• W2316872222 cites W2081995675 @default.
• W2316872222 cites W2084877923 @default.
• W2316872222 cites W2108660560 @default.
• W2316872222 cites W2109956821 @default.
• W2316872222 cites W2113353533 @default.
• W2316872222 cites W2116726373 @default.
• W2316872222 cites W2118374257 @default.
• W2316872222 cites W2119576204 @default.
• W2316872222 cites W2121171143 @default.
• W2316872222 cites W2124015844 @default.
• W2316872222 cites W2132878122 @default.
• W2316872222 cites W2133982409 @default.
• W2316872222 cites W2157976579 @default.
• W2316872222 cites W2170547471 @default.
• W2316872222 cites W2170630327 @default.
• W2316872222 cites W2323183774 @default.
• W2316872222 cites W2323640168 @default.
• W2316872222 cites W2324209741 @default.
• W2316872222 cites W2330317414 @default.
• W2316872222 cites W2332030987 @default.
• W2316872222 doi "https://doi.org/10.1021/bm501652d" @default.
• W2316872222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25555025" @default.
• W2316872222 hasPublicationYear "2015" @default.
• W2316872222 type Work @default.
• W2316872222 sameAs 2316872222 @default.
• W2316872222 citedByCount "52" @default.
• W2316872222 countsByYear W23168722222015 @default.
• W2316872222 countsByYear W23168722222016 @default.
• W2316872222 countsByYear W23168722222017 @default.
• W2316872222 countsByYear W23168722222018 @default.
• W2316872222 countsByYear W23168722222019 @default.
• W2316872222 countsByYear W23168722222020 @default.
• W2316872222 countsByYear W23168722222021 @default.
• W2316872222 countsByYear W23168722222022 @default.
• W2316872222 countsByYear W23168722222023 @default.
• W2316872222 crossrefType "journal-article" @default.
• W2316872222 hasAuthorship W2316872222A5011696248 @default.
• W2316872222 hasAuthorship W2316872222A5024490292 @default.
• W2316872222 hasAuthorship W2316872222A5026189929 @default.
• W2316872222 hasAuthorship W2316872222A5039037778 @default.
• W2316872222 hasAuthorship W2316872222A5058784587 @default.
• W2316872222 hasAuthorship W2316872222A5072931528 @default.
• W2316872222 hasAuthorship W2316872222A5077781605 @default.
• W2316872222 hasAuthorship W2316872222A5081367381 @default.
• W2316872222 hasBestOaLocation W23168722222 @default.
• W2316872222 hasConcept C13965031 @default.
• W2316872222 hasConcept C178790620 @default.
• W2316872222 hasConcept C181199279 @default.
• W2316872222 hasConcept C185592680 @default.
• W2316872222 hasConcept C188027245 @default.
• W2316872222 hasConcept C2775997276 @default.
• W2316872222 hasConcept C2777824588 @default.

• next