FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316876843> ?p ?o ?g. }

• W2316876843 endingPage "86" @default.
• W2316876843 startingPage "79" @default.
• W2316876843 abstract "Antineutrophil cytoplasmic autoantibodies (ANCA) play a role in the expression of adhesion molecules. Differences in ANCA test results in ANCA-associated vasculitis may provide differences in their renal expression.We assessed the renal expression of ICAM-1 and VCAM-1 with monoclonal antibodies in 19 patients with ANCA-vasculitis: 7 microscopic polyangiitis, 5 Wegener's granulomatosis, 4 renal-limited vasculitis and 3 Churg-Strauss disease. Immunofluorescence and ELISA for myeloperoxidase (MPO) and proteinase 3 (PR3) were performed for ANCA-testing. 10 normal renal tissues were used as controls.The ANCA staining pattern was perinuclear in 14 patients, with MPO-ANCA 31 - 220 EU/ml, and cytoplasmic in 5, with PR3-ANCA 37 - 144 EU/ml. Abnormal tubular expression of ICAM-1 and VCAM-1 was seen in more than 80% of biopsies and abnormal expression of VCAM-1 in glomerular tuft was seen in 60%. Glomerular tuft stains of ++ or +++ for VCAM-1 were observed in 10% of renal biopsies from MPO-ANCA-GN patients, but in 60% of biopsies from PR3-ANCA-GN patients (Fi = 8.538, p = 0.03).De novo expression of VCAM-1 on glomerular tuft suggests that the endothelial cells play a role in ANCA-GN. De novo glomerular expression of VCAM-1 is associated more with ANCA directed against PR3 than with ANCA directed against MPO. Upregulated glomerular expression of VCAM-1 may reflect a higher histological activity in patients with PR3-ANCA, and supports the existence of specific immune activation mechanisms in the different serologic subgroups in ANCA-GN. The de novo tubular expression of ICAM-1 and VCAM-1 suggests that the epithelial cells may participate in adhesive interactions in ANCA-GN." @default.
• W2316876843 created "2016-06-24" @default.
• W2316876843 creator A5008866975 @default.
• W2316876843 creator A5020063514 @default.
• W2316876843 creator A5041691301 @default.
• W2316876843 creator A5050917806 @default.
• W2316876843 creator A5060973314 @default.
• W2316876843 date "2006-02-01" @default.
• W2316876843 modified "2023-09-27" @default.
• W2316876843 title "Renal expression of ICAM-1 and VCAM-1 in ANCA-associated glomerulonephritis – are there differences among serologic subgroups?" @default.
• W2316876843 doi "https://doi.org/10.5414/cnp65079" @default.
• W2316876843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16509455" @default.
• W2316876843 hasPublicationYear "2006" @default.
• W2316876843 type Work @default.
• W2316876843 sameAs 2316876843 @default.
• W2316876843 citedByCount "6" @default.
• W2316876843 countsByYear W23168768432012 @default.
• W2316876843 countsByYear W23168768432014 @default.
• W2316876843 countsByYear W23168768432020 @default.
• W2316876843 countsByYear W23168768432022 @default.
• W2316876843 crossrefType "journal-article" @default.
• W2316876843 hasAuthorship W2316876843A5008866975 @default.
• W2316876843 hasAuthorship W2316876843A5020063514 @default.
• W2316876843 hasAuthorship W2316876843A5041691301 @default.
• W2316876843 hasAuthorship W2316876843A5050917806 @default.
• W2316876843 hasAuthorship W2316876843A5060973314 @default.
• W2316876843 hasConcept C126322002 @default.
• W2316876843 hasConcept C142724271 @default.
• W2316876843 hasConcept C159654299 @default.
• W2316876843 hasConcept C16224149 @default.
• W2316876843 hasConcept C163764329 @default.
• W2316876843 hasConcept C185946421 @default.
• W2316876843 hasConcept C203014093 @default.
• W2316876843 hasConcept C203565725 @default.
• W2316876843 hasConcept C21194631 @default.
• W2316876843 hasConcept C24040308 @default.
• W2316876843 hasConcept C2775934546 @default.
• W2316876843 hasConcept C2775998817 @default.
• W2316876843 hasConcept C2776015282 @default.
• W2316876843 hasConcept C2776914184 @default.
• W2316876843 hasConcept C2776985958 @default.
• W2316876843 hasConcept C2777146197 @default.
• W2316876843 hasConcept C2778910314 @default.
• W2316876843 hasConcept C2779134260 @default.
• W2316876843 hasConcept C2779561371 @default.
• W2316876843 hasConcept C2780091579 @default.
• W2316876843 hasConcept C2780368995 @default.
• W2316876843 hasConcept C2780819817 @default.
• W2316876843 hasConcept C2781087799 @default.
• W2316876843 hasConcept C2781156571 @default.
• W2316876843 hasConcept C45189115 @default.
• W2316876843 hasConcept C54847362 @default.
• W2316876843 hasConcept C71924100 @default.
• W2316876843 hasConceptScore W2316876843C126322002 @default.
• W2316876843 hasConceptScore W2316876843C142724271 @default.
• W2316876843 hasConceptScore W2316876843C159654299 @default.
• W2316876843 hasConceptScore W2316876843C16224149 @default.
• W2316876843 hasConceptScore W2316876843C163764329 @default.
• W2316876843 hasConceptScore W2316876843C185946421 @default.
• W2316876843 hasConceptScore W2316876843C203014093 @default.
• W2316876843 hasConceptScore W2316876843C203565725 @default.
• W2316876843 hasConceptScore W2316876843C21194631 @default.
• W2316876843 hasConceptScore W2316876843C24040308 @default.
• W2316876843 hasConceptScore W2316876843C2775934546 @default.
• W2316876843 hasConceptScore W2316876843C2775998817 @default.
• W2316876843 hasConceptScore W2316876843C2776015282 @default.
• W2316876843 hasConceptScore W2316876843C2776914184 @default.
• W2316876843 hasConceptScore W2316876843C2776985958 @default.
• W2316876843 hasConceptScore W2316876843C2777146197 @default.
• W2316876843 hasConceptScore W2316876843C2778910314 @default.
• W2316876843 hasConceptScore W2316876843C2779134260 @default.
• W2316876843 hasConceptScore W2316876843C2779561371 @default.
• W2316876843 hasConceptScore W2316876843C2780091579 @default.
• W2316876843 hasConceptScore W2316876843C2780368995 @default.
• W2316876843 hasConceptScore W2316876843C2780819817 @default.
• W2316876843 hasConceptScore W2316876843C2781087799 @default.
• W2316876843 hasConceptScore W2316876843C2781156571 @default.
• W2316876843 hasConceptScore W2316876843C45189115 @default.
• W2316876843 hasConceptScore W2316876843C54847362 @default.
• W2316876843 hasConceptScore W2316876843C71924100 @default.
• W2316876843 hasIssue "02" @default.
• W2316876843 hasLocation W23168768431 @default.
• W2316876843 hasLocation W23168768432 @default.
• W2316876843 hasOpenAccess W2316876843 @default.
• W2316876843 hasPrimaryLocation W23168768431 @default.
• W2316876843 hasRelatedWork W164635967 @default.
• W2316876843 hasRelatedWork W1970069359 @default.
• W2316876843 hasRelatedWork W1970898370 @default.
• W2316876843 hasRelatedWork W1984285143 @default.
• W2316876843 hasRelatedWork W2007398898 @default.
• W2316876843 hasRelatedWork W2036066587 @default.
• W2316876843 hasRelatedWork W2062030308 @default.
• W2316876843 hasRelatedWork W2316876843 @default.
• W2316876843 hasRelatedWork W2404654737 @default.
• W2316876843 hasRelatedWork W2342033846 @default.
• W2316876843 hasVolume "65" @default.
• W2316876843 isParatext "false" @default.
• W2316876843 isRetracted "false" @default.

• next