Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316902912> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2316902912 endingPage "324" @default.
- W2316902912 startingPage "317" @default.
- W2316902912 abstract "The immunoregulatory effect of non-transferrin-bound iron (Fe3+) on the proliferative and cytotoxic responses of normal human T lymphocytes was studied using a sensitive limit-dilution technique capable of detecting the responses of individual lymphocytes. Iron, present in the form of ferric citrate at concentrations from 0·03 to 1·0 mmol/L. significantly reduced the cloning frequency of peripheral blood T lymphocytes. The effect of iron appeared, however, to be targeted to individual clones in that some clones that did grow in the presence of iron achieved a normal rate of proliferation. Thus, iron was not non-specifically toxic. At these same concentrations ferric citrate also produced significant reductions in the cloning frequency of CD4 + CD8- precursor T lymphocytes. Reductions in the response of T lymphocyte precursors capable of cytotoxic activity occurred in the presence of ferric citrate from 0·1 to 1·0 mmol/L. These data support the hypothesis that non-transferrin-bound iron has an immunoregulatory role in cell-mediated immunity." @default.
- W2316902912 created "2016-06-24" @default.
- W2316902912 creator A5012628085 @default.
- W2316902912 creator A5020773465 @default.
- W2316902912 creator A5035536310 @default.
- W2316902912 creator A5050278607 @default.
- W2316902912 creator A5058399464 @default.
- W2316902912 date "1990-10-01" @default.
- W2316902912 modified "2023-09-27" @default.
- W2316902912 title "Clonal analysis of the effect of iron on human cytotoxic and proliferating T lymphocytes" @default.
- W2316902912 cites W1512833508 @default.
- W2316902912 cites W1870525143 @default.
- W2316902912 cites W1979601721 @default.
- W2316902912 cites W1984579458 @default.
- W2316902912 cites W2023201913 @default.
- W2316902912 cites W2024962053 @default.
- W2316902912 cites W2039419274 @default.
- W2316902912 cites W2056149198 @default.
- W2316902912 cites W2060515380 @default.
- W2316902912 cites W2061055430 @default.
- W2316902912 cites W2071934246 @default.
- W2316902912 cites W2077173353 @default.
- W2316902912 cites W2079775232 @default.
- W2316902912 cites W2107359414 @default.
- W2316902912 cites W2119397834 @default.
- W2316902912 cites W2137292798 @default.
- W2316902912 cites W2314218964 @default.
- W2316902912 cites W2403750889 @default.
- W2316902912 cites W2427510662 @default.
- W2316902912 doi "https://doi.org/10.1038/icb.1990.43" @default.
- W2316902912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2150666" @default.
- W2316902912 hasPublicationYear "1990" @default.
- W2316902912 type Work @default.
- W2316902912 sameAs 2316902912 @default.
- W2316902912 citedByCount "17" @default.
- W2316902912 countsByYear W23169029122013 @default.
- W2316902912 countsByYear W23169029122021 @default.
- W2316902912 crossrefType "journal-article" @default.
- W2316902912 hasAuthorship W2316902912A5012628085 @default.
- W2316902912 hasAuthorship W2316902912A5020773465 @default.
- W2316902912 hasAuthorship W2316902912A5035536310 @default.
- W2316902912 hasAuthorship W2316902912A5050278607 @default.
- W2316902912 hasAuthorship W2316902912A5058399464 @default.
- W2316902912 hasConcept C121050878 @default.
- W2316902912 hasConcept C153911025 @default.
- W2316902912 hasConcept C154317977 @default.
- W2316902912 hasConcept C167672396 @default.
- W2316902912 hasConcept C178790620 @default.
- W2316902912 hasConcept C185592680 @default.
- W2316902912 hasConcept C199360897 @default.
- W2316902912 hasConcept C202751555 @default.
- W2316902912 hasConcept C203014093 @default.
- W2316902912 hasConcept C22814914 @default.
- W2316902912 hasConcept C2777761686 @default.
- W2316902912 hasConcept C2780534640 @default.
- W2316902912 hasConcept C41008148 @default.
- W2316902912 hasConcept C55493867 @default.
- W2316902912 hasConcept C86803240 @default.
- W2316902912 hasConcept C8891405 @default.
- W2316902912 hasConceptScore W2316902912C121050878 @default.
- W2316902912 hasConceptScore W2316902912C153911025 @default.
- W2316902912 hasConceptScore W2316902912C154317977 @default.
- W2316902912 hasConceptScore W2316902912C167672396 @default.
- W2316902912 hasConceptScore W2316902912C178790620 @default.
- W2316902912 hasConceptScore W2316902912C185592680 @default.
- W2316902912 hasConceptScore W2316902912C199360897 @default.
- W2316902912 hasConceptScore W2316902912C202751555 @default.
- W2316902912 hasConceptScore W2316902912C203014093 @default.
- W2316902912 hasConceptScore W2316902912C22814914 @default.
- W2316902912 hasConceptScore W2316902912C2777761686 @default.
- W2316902912 hasConceptScore W2316902912C2780534640 @default.
- W2316902912 hasConceptScore W2316902912C41008148 @default.
- W2316902912 hasConceptScore W2316902912C55493867 @default.
- W2316902912 hasConceptScore W2316902912C86803240 @default.
- W2316902912 hasConceptScore W2316902912C8891405 @default.
- W2316902912 hasIssue "5" @default.
- W2316902912 hasLocation W23169029121 @default.
- W2316902912 hasLocation W23169029122 @default.
- W2316902912 hasOpenAccess W2316902912 @default.
- W2316902912 hasPrimaryLocation W23169029121 @default.
- W2316902912 hasRelatedWork W1967623526 @default.
- W2316902912 hasRelatedWork W1980416103 @default.
- W2316902912 hasRelatedWork W2018916009 @default.
- W2316902912 hasRelatedWork W2054101033 @default.
- W2316902912 hasRelatedWork W2090531156 @default.
- W2316902912 hasRelatedWork W2152575655 @default.
- W2316902912 hasRelatedWork W2164587311 @default.
- W2316902912 hasRelatedWork W4220809286 @default.
- W2316902912 hasRelatedWork W4286560817 @default.
- W2316902912 hasRelatedWork W4316804851 @default.
- W2316902912 hasVolume "68" @default.
- W2316902912 isParatext "false" @default.
- W2316902912 isRetracted "false" @default.
- W2316902912 magId "2316902912" @default.
- W2316902912 workType "article" @default.