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- W2316910551 abstract "Context: Numerous variations in ghrelin gene have been established to be associated with obesity parameters and ghrelin level. Aims: to focus on single nucleotide polymorphism (SNP) 501A>C in ghrelin gene and study the association of its different genotypes with certain obesity parameters and examine the relationship of these genotypes with ghrelin levels. Settings and Design: The study included 88 unrelated obese subjects recruited from the outpatient clinics in king Abdul-Aziz hospital, Taif, KSA. Age and sex matched 56 unrelated healthy subjects serving as healthy controls. Methods and Material: Waist circumferences (WC) were measured and the body mass index (BMI) was calculated. Fasting serum leptin and ghrelin levels were determined using commercially available ELISA kits. SNP 501A>C in ghrelin gene was studied by restriction fragment length polymorphism (RFLP).The DNA fragment containing the SNP was amplified by PCR. Statistical analysis used: One-way analysis of variance (ANOVA) and simple linear regression analysis were analyzed using Package for Social Sciences (SPSS) software for Windows (version 12.0; SPSS Inc., Chicago, IL, USA). Results: BMI and WC were not significantly different in the SNP genotypes of both groups. In the obese group, Ghrelin level was significantly different in both groups regarding the three SNP genotypes. Ghrelin levels may be associated with -501A˃A and -501A˃C genotypes in obese. Conclusions: Anthropometric parameters were not significantly different in the SNP genotypes of both groups, while ghrelin level was significantly different regarding the three SNP genotypes. Ghrelin levels may be associated with -501A˃C variant in obese. Key-words: Single nucleotide polymorphism - 5- flanke ghrelin gene - obesity -Saudi subjects" @default.
- W2316910551 created "2016-06-24" @default.
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- W2316910551 date "2014-01-01" @default.
- W2316910551 modified "2023-09-25" @default.
- W2316910551 title "Association of single nucleotide polymorphism of 5- flanke ghrelin gene with obesity in Saudi subjects" @default.
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- W2316910551 doi "https://doi.org/10.9790/0853-131013035" @default.
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