FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316923815> ?p ?o ?g. }

• W2316923815 endingPage "A13" @default.
• W2316923815 startingPage "A13.2" @default.
• W2316923815 abstract "<h3>Introduction</h3> The origin and development of Barrett’s oesophagus has long been discussed, with three main proposals for the origin of metaplasia: from oesophageal squamous epithelium, from upward migration of cardiac glands, or from submucosal glands. <h3>Methods</h3> In Barrett’s glands we have studied the distribution of proliferative activity using Ki67 and the migration of cells in Barrett’s glands from patients infused with iododeoxyuridine 7 and 11 days pre-oesophagectomy. We have localised gene expression of mucins using immunohistochemistry (IHC) and trefoil family factor (TFF) peptides using IHC and <i>in situ</i> hybridization (ISH) and the stem cell marker Lgr5 using ISH, combining this with analysis of the clonal architecture of Barrett’s glands using mitochondrial DNA (mtDNA) as a clonal marker. <h3>Results</h3> In Barrett’s glands proliferation is seen mainly in the middle part of the gland and diminishes towards the surface and the base of the gland. Cells migrate in a bidirectional manner. MUC5AC and TFF1 expression are found superficially, while MUC6 and TFF2 are found at the bases of the glands, similar to the distribution seen in antral gastric glands: MUC2, staining goblet cells and columnar cells, is concentrated superficially. <i>Lgr5</i> mRNA is also found in the middle part of the glands, indicating the location of the stem cell niche. Barrett’s glands are clonal, indicating derivation from a single cell, and suggesting that Barrett’s stem cells have dual differentiation capacity. Gastric intestinal metaplasia, on the other hand, shows basal <i>Lgr5</i> mRNA localisation with a distribution of proliferative activity similar to intestinal crypts. <h3>Conclusion</h3> We conclude that Barrett’s glands show the proliferative and stem cell architecture, and preserve patterns of gene expression of pyloric-type gastric glands, but are maintained by unique stem cells with both gastric and intestinal differentiation capacity: we propose that Barrett’s glands originate as gastric glands and that subsequent intestinal differentiation advances with time, strongly supporting an origin from the proximal cardiac mucosa. <h3>Disclosure of Interest</h3> None Declared" @default.
• W2316923815 created "2016-06-24" @default.
• W2316923815 creator A5000353679 @default.
• W2316923815 creator A5010990967 @default.
• W2316923815 creator A5011340913 @default.
• W2316923815 creator A5025576054 @default.
• W2316923815 creator A5034762894 @default.
• W2316923815 creator A5035868689 @default.
• W2316923815 creator A5036343699 @default.
• W2316923815 creator A5037946370 @default.
• W2316923815 creator A5042860532 @default.
• W2316923815 creator A5043932592 @default.
• W2316923815 creator A5045327103 @default.
• W2316923815 creator A5085100825 @default.
• W2316923815 date "2013-06-01" @default.
• W2316923815 modified "2023-10-18" @default.
• W2316923815 title "OC-030 Barrett’S Epithelium Shows Evidence of Gastric and Intestinal Differentiation Programmes but Preserves the Proliferative and Stem Cell Architecture of Gastric Glands" @default.
• W2316923815 doi "https://doi.org/10.1136/gutjnl-2013-304907.030" @default.
• W2316923815 hasPublicationYear "2013" @default.
• W2316923815 type Work @default.
• W2316923815 sameAs 2316923815 @default.
• W2316923815 citedByCount "0" @default.
• W2316923815 crossrefType "journal-article" @default.
• W2316923815 hasAuthorship W2316923815A5000353679 @default.
• W2316923815 hasAuthorship W2316923815A5010990967 @default.
• W2316923815 hasAuthorship W2316923815A5011340913 @default.
• W2316923815 hasAuthorship W2316923815A5025576054 @default.
• W2316923815 hasAuthorship W2316923815A5034762894 @default.
• W2316923815 hasAuthorship W2316923815A5035868689 @default.
• W2316923815 hasAuthorship W2316923815A5036343699 @default.
• W2316923815 hasAuthorship W2316923815A5037946370 @default.
• W2316923815 hasAuthorship W2316923815A5042860532 @default.
• W2316923815 hasAuthorship W2316923815A5043932592 @default.
• W2316923815 hasAuthorship W2316923815A5045327103 @default.
• W2316923815 hasAuthorship W2316923815A5085100825 @default.
• W2316923815 hasBestOaLocation W23169238151 @default.
• W2316923815 hasConcept C10116572 @default.
• W2316923815 hasConcept C104317684 @default.
• W2316923815 hasConcept C121608353 @default.
• W2316923815 hasConcept C134018914 @default.
• W2316923815 hasConcept C136302470 @default.
• W2316923815 hasConcept C142724271 @default.
• W2316923815 hasConcept C150194340 @default.
• W2316923815 hasConcept C179264091 @default.
• W2316923815 hasConcept C203014093 @default.
• W2316923815 hasConcept C204232928 @default.
• W2316923815 hasConcept C2776145723 @default.
• W2316923815 hasConcept C2776497702 @default.
• W2316923815 hasConcept C2777116383 @default.
• W2316923815 hasConcept C2777882243 @default.
• W2316923815 hasConcept C2778052355 @default.
• W2316923815 hasConcept C2778148616 @default.
• W2316923815 hasConcept C2779357193 @default.
• W2316923815 hasConcept C2779422922 @default.
• W2316923815 hasConcept C2781443798 @default.
• W2316923815 hasConcept C28328180 @default.
• W2316923815 hasConcept C529295009 @default.
• W2316923815 hasConcept C54355233 @default.
• W2316923815 hasConcept C55427017 @default.
• W2316923815 hasConcept C55493867 @default.
• W2316923815 hasConcept C71924100 @default.
• W2316923815 hasConcept C81439078 @default.
• W2316923815 hasConcept C86803240 @default.
• W2316923815 hasConcept C90378955 @default.
• W2316923815 hasConcept C95444343 @default.
• W2316923815 hasConceptScore W2316923815C10116572 @default.
• W2316923815 hasConceptScore W2316923815C104317684 @default.
• W2316923815 hasConceptScore W2316923815C121608353 @default.
• W2316923815 hasConceptScore W2316923815C134018914 @default.
• W2316923815 hasConceptScore W2316923815C136302470 @default.
• W2316923815 hasConceptScore W2316923815C142724271 @default.
• W2316923815 hasConceptScore W2316923815C150194340 @default.
• W2316923815 hasConceptScore W2316923815C179264091 @default.
• W2316923815 hasConceptScore W2316923815C203014093 @default.
• W2316923815 hasConceptScore W2316923815C204232928 @default.
• W2316923815 hasConceptScore W2316923815C2776145723 @default.
• W2316923815 hasConceptScore W2316923815C2776497702 @default.
• W2316923815 hasConceptScore W2316923815C2777116383 @default.
• W2316923815 hasConceptScore W2316923815C2777882243 @default.
• W2316923815 hasConceptScore W2316923815C2778052355 @default.
• W2316923815 hasConceptScore W2316923815C2778148616 @default.
• W2316923815 hasConceptScore W2316923815C2779357193 @default.
• W2316923815 hasConceptScore W2316923815C2779422922 @default.
• W2316923815 hasConceptScore W2316923815C2781443798 @default.
• W2316923815 hasConceptScore W2316923815C28328180 @default.
• W2316923815 hasConceptScore W2316923815C529295009 @default.
• W2316923815 hasConceptScore W2316923815C54355233 @default.
• W2316923815 hasConceptScore W2316923815C55427017 @default.
• W2316923815 hasConceptScore W2316923815C55493867 @default.
• W2316923815 hasConceptScore W2316923815C71924100 @default.
• W2316923815 hasConceptScore W2316923815C81439078 @default.
• W2316923815 hasConceptScore W2316923815C86803240 @default.
• W2316923815 hasConceptScore W2316923815C90378955 @default.
• W2316923815 hasConceptScore W2316923815C95444343 @default.
• W2316923815 hasIssue "Suppl 1" @default.
• W2316923815 hasLocation W23169238151 @default.
• W2316923815 hasOpenAccess W2316923815 @default.
• W2316923815 hasPrimaryLocation W23169238151 @default.

• next