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- W2316942023 abstract "1Epidemiological studies show that dietary intake of ascorbic acid correlate inversely with hypertension and its clinical sequelae. 2,3 We examined the effect of ascorbic acid treatment on blood pressure. Otherwise healthy patients with hypertension (a history of antihypertensive treatment or untreated diastolic blood pressure >90 mm Hg) were recruited by advertisement and provided informed consent. Exclusion criteria included coronary artery disease, diabetes mellitus, uncontrolled hypertension (diastolic blood pressure >110 mm Hg), heart failure, and use of antioxidants or oestrogens within one month. Patients fasted overnight, and, if applicable, did not smoke for 24 h before two visits, one month apart. Shortacting and long-acting vasoactive medications were withheld for 12 and 24 h, respectively, before both visits. Otherwise, antihypertensives were continued throughout the study period. Blood and urine samples were collected at each visit, and circulatory indices measured after 10 min semirecumbent rest, with an automated monitor (Dinamap XL). In a double-blinded manner, patients were randomised to treatment with ascorbic acid or matched placebo tablets (Leiner Health Products, Carson, CA). Measurements were repeated 2 h after a 2 g dose and after continuation of assigned treatment for 30 days (500 mg/day). Baseline characteristics were compared with unpaired t test, 2 test or Fisher’s exact test as appropriate. The effect of treatment (by intention-to-treat) was compared by two-way (treatment and time) repeated measures ANOVA, with post hoc Student-Newman-Keuls comparison. 45 patients were enrolled. Three from each group did not return for follow-up. Baseline characteristics were balanced (table). As shown in the figure, systolic blood pressure in the two groups was similar at baseline and after acute treatment. 1 month of ascorbic acid treatment decreased systolic blood pressure (mean 155 [SD 22] to 142 [16] mm Hg, p<0·001), whereas placebo had no effect. This difference between treatments was significant (p=0·03). Mean blood pressures were similar at baseline and after acute treatment. However, after 1 month, ascorbic acid decreased mean blood pressure from 110 (12) to 100 (8) mm Hg, p<0·001, and the effect was significantly different from placebo (p=0·02). Diastolic blood pressures were similar at baseline and after acute treatment. After 1 month, ascorbic acid decreased diastolic blood" @default.
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- W2316942023 date "1999-01-01" @default.
- W2316942023 modified "2023-09-27" @default.
- W2316942023 title "Treatment of hy pertension with ascorbic acid" @default.
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