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• W2316943553 abstract "Event Abstract Back to Event Pituitary Adenylate Cyclase-Activating Polypeptide plays an important role in nitroglycerol-induced trigeminovascular activation in mice A. Markovics1*, A. Lashgarara1, E. Szőke1, K. Sándor1, B. Tuka2, V. Kormos1, J. Tajti2, J. Szolcsányi1, B. Gaszner3, D. Reglődi3, H. Hashimoto4 and Z. Helyes1 1 University of Pécs, Department of Pharmacology and Pharmacotherapy, Hungary 2 University of Szeged, Department of Neurology, Hungary 3 University of Pécs, Department of Anatomy, Hungary 4 Osaka University, Graduate School of Pharmaceutical Sciences, Japan Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and its receptors are present in sensory neurones and vascular smooth muscle. Its infusion triggers migraine-like headache in humans. Therefore, we aimed at examining the effects of PACAP in nitroglycerol (NG)-induced light-aversive behavior, meningeal vasodilatation and c-Fos expression in the trigeminal nucleus and ganglia using gene-deleted mice (PACAP-/-). Significantly reduced light-aversive behaviour was detected in the modified light-dark box in PACAP-/- mice both in the early phase (0-30 min) due to the acute vasodilating effect of NG (10 mg/kg i.p.) and in the late phase (90-120 min) when the trigeminal system is sensitized. NG produced significant (30-35%) biphasic increase of meningeal blood flow measured by laser Doppler imaging in anaesthesized mice with a second peak starting 170 minutes after its injection. In contrast, in PACAP-/- mice NG did not alter microcirculation in the first 2 h-period and exerted only a minor increase later. Exogenous PACAP (300 mg/kg i.p.) produced 30% meningeal flow increase. C-Fos expression in the trigeminal ganglia and nucleus caudalis was also significantly smaller in PACAP-/- mice. PACAP has both direct and indirect vasodilating effects on the brain surface, and also activates the trigeminovascular system involved in migraine. Exploration of its mechanism and targets might open interesting future perspectives in novel anti-migraine therapy. Keywords: Neurophysiology, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Neurophysiology Citation: Markovics A, Lashgarara A, Szőke E, Sándor K, Tuka B, Kormos V, Tajti J, Szolcsányi J, Gaszner B, Reglődi D, Hashimoto H and Helyes Z (2011). Pituitary Adenylate Cyclase-Activating Polypeptide plays an important role in nitroglycerol-induced trigeminovascular activation in mice. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00174 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. A. Markovics, University of Pécs, Department of Pharmacology and Pharmacotherapy, Pécs, Hungary, adri.markovics@yahoo.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers A. Markovics A. Lashgarara E. Szőke K. Sándor B. Tuka V. Kormos J. Tajti J. Szolcsányi B. Gaszner D. Reglődi H. Hashimoto Z. Helyes Google A. Markovics A. Lashgarara E. Szőke K. Sándor B. Tuka V. Kormos J. Tajti J. Szolcsányi B. Gaszner D. Reglődi H. Hashimoto Z. Helyes Google Scholar A. Markovics A. Lashgarara E. Szőke K. Sándor B. Tuka V. Kormos J. Tajti J. Szolcsányi B. Gaszner D. Reglődi H. Hashimoto Z. Helyes PubMed A. Markovics A. Lashgarara E. Szőke K. Sándor B. Tuka V. Kormos J. Tajti J. Szolcsányi B. Gaszner D. Reglődi H. Hashimoto Z. Helyes Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2316943553 title "Pituitary Adenylate Cyclase-Activating Polypeptide plays an important role in nitroglycerol-induced trigeminovascular activation in mice" @default.
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