Matches in SemOpenAlex for { <https://semopenalex.org/work/W2316972904> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2316972904 endingPage "263" @default.
- W2316972904 startingPage "256" @default.
- W2316972904 abstract "It was demonstrated that the reaction of some cell species to peanut agglutinin (PNA) involved the maturity of the cells. We investigated the selective adhesion of circulating hemopoietic cells and lymphoid cells to hepatic sinusoidal cells. We experimented with thymocyte (TYC) models that could be easily isolated into PNA positive [PNA(+)] and PNA negative [PNA(-)] subsets, and transfused these subsets, labeled with 51Cr into the isogenic mice, then measured the radioactivity in the kidney, lung, spleen, liver, Peyer's patch (P.P.), and thymus, after 48 hrs. The radioactivity (% total dose recovered) in the liver and spleen represented the degree of cellular distribution and indicated that a significantly higher dose had accumulated in the liver and spleen than in other organs. Additionally, TYC-PNA(+), recognized to be immature cells, demonstrated high aggregation in the liver, while TYCPNA(-), recognized to be mature cells, demonstrated high aggregation in the spleen. Similar results were observed in our subsequent experiment using wheat germ agglutinin (WGA), other indicator of maturity, and spleen cells (SPC). Next, we transfused TYC-PNA(+) to mice at various intervals after 70% hepatectomy. The degree of aggregation (radioactivity/ weight) in the liver was reduced 1 day after hepatectomy, and that in the spleen increased proportionately. Whereas the aggregation degree of, TYC-PNA(-) in the same experiment did not change significantly.We postulated that hepatic sinusoidal cells recognize and, sequentially, trap specific carbohydrates on lymphoid cells by a lectin, PNA or WGA, like receptor. Reviewing our previous report, adhesion to Kupffer cells indused SPC activation and proliferation, this recognition and trapping mechanism seems to play an important role of intrahepatic hematolymphoid system. (J Nippon Med Sch 1997; 64: 256-263)" @default.
- W2316972904 created "2016-06-24" @default.
- W2316972904 creator A5000755477 @default.
- W2316972904 creator A5034575449 @default.
- W2316972904 creator A5087070845 @default.
- W2316972904 date "1997-01-01" @default.
- W2316972904 modified "2023-09-25" @default.
- W2316972904 title "The role of hepatic sinusoidal cells in homing of lymphocytes. Preferential hepatic trapping of PNA(+) lymphocyte and its modulation during liver regeneration." @default.
- W2316972904 doi "https://doi.org/10.1272/jnms1923.64.256" @default.
- W2316972904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9217369" @default.
- W2316972904 hasPublicationYear "1997" @default.
- W2316972904 type Work @default.
- W2316972904 sameAs 2316972904 @default.
- W2316972904 citedByCount "0" @default.
- W2316972904 crossrefType "journal-article" @default.
- W2316972904 hasAuthorship W2316972904A5000755477 @default.
- W2316972904 hasAuthorship W2316972904A5034575449 @default.
- W2316972904 hasAuthorship W2316972904A5087070845 @default.
- W2316972904 hasBestOaLocation W23169729041 @default.
- W2316972904 hasConcept C126322002 @default.
- W2316972904 hasConcept C134018914 @default.
- W2316972904 hasConcept C151872237 @default.
- W2316972904 hasConcept C153911025 @default.
- W2316972904 hasConcept C171056886 @default.
- W2316972904 hasConcept C181152851 @default.
- W2316972904 hasConcept C185592680 @default.
- W2316972904 hasConcept C18903297 @default.
- W2316972904 hasConcept C203014093 @default.
- W2316972904 hasConcept C2776795407 @default.
- W2316972904 hasConcept C2777626840 @default.
- W2316972904 hasConcept C2777761686 @default.
- W2316972904 hasConcept C2780175098 @default.
- W2316972904 hasConcept C2780758401 @default.
- W2316972904 hasConcept C2780931953 @default.
- W2316972904 hasConcept C71924100 @default.
- W2316972904 hasConcept C86803240 @default.
- W2316972904 hasConcept C95444343 @default.
- W2316972904 hasConceptScore W2316972904C126322002 @default.
- W2316972904 hasConceptScore W2316972904C134018914 @default.
- W2316972904 hasConceptScore W2316972904C151872237 @default.
- W2316972904 hasConceptScore W2316972904C153911025 @default.
- W2316972904 hasConceptScore W2316972904C171056886 @default.
- W2316972904 hasConceptScore W2316972904C181152851 @default.
- W2316972904 hasConceptScore W2316972904C185592680 @default.
- W2316972904 hasConceptScore W2316972904C18903297 @default.
- W2316972904 hasConceptScore W2316972904C203014093 @default.
- W2316972904 hasConceptScore W2316972904C2776795407 @default.
- W2316972904 hasConceptScore W2316972904C2777626840 @default.
- W2316972904 hasConceptScore W2316972904C2777761686 @default.
- W2316972904 hasConceptScore W2316972904C2780175098 @default.
- W2316972904 hasConceptScore W2316972904C2780758401 @default.
- W2316972904 hasConceptScore W2316972904C2780931953 @default.
- W2316972904 hasConceptScore W2316972904C71924100 @default.
- W2316972904 hasConceptScore W2316972904C86803240 @default.
- W2316972904 hasConceptScore W2316972904C95444343 @default.
- W2316972904 hasIssue "3" @default.
- W2316972904 hasLocation W23169729041 @default.
- W2316972904 hasLocation W23169729042 @default.
- W2316972904 hasOpenAccess W2316972904 @default.
- W2316972904 hasPrimaryLocation W23169729041 @default.
- W2316972904 hasRelatedWork W1963499284 @default.
- W2316972904 hasRelatedWork W1981966981 @default.
- W2316972904 hasRelatedWork W1983905836 @default.
- W2316972904 hasRelatedWork W1990009149 @default.
- W2316972904 hasRelatedWork W2011611612 @default.
- W2316972904 hasRelatedWork W2050594902 @default.
- W2316972904 hasRelatedWork W2066233537 @default.
- W2316972904 hasRelatedWork W2316972904 @default.
- W2316972904 hasRelatedWork W2412827997 @default.
- W2316972904 hasRelatedWork W2994398833 @default.
- W2316972904 hasVolume "64" @default.
- W2316972904 isParatext "false" @default.
- W2316972904 isRetracted "false" @default.
- W2316972904 magId "2316972904" @default.
- W2316972904 workType "article" @default.