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- W2316973399 abstract "OBJECTIVES: To examine whether the lactate kinetics during exercise are abnormal in patients with chronic obstructive pulmonary disease (COPD) and to evaluate the relationship of lactate kinetics with functional status. POPULATION: Fifty-four patients with COPD (forced expiratory volume in 1 s [FEV 1 ] [mean ± SD] 36±12% predicted, range 19 to 70) and 10 healthy, age-matched normal men were included in this study. INTERVENTION: Each subject performed a stepwise exercise test up to maximal capacity during which five-breath averages of oxygen uptake (VO 2 ) were obtained. Arterial plasma lactate (La) concentration was also measured at each one-minute exercise step. The La/VO 2 relationship during exercise was fitted by an exponential function La = a + b VO 2 where b represents the steepness of the relationship. Patients' functional status was classified according to the peak VO 2 : more than 16 mL/min/kg and 20 mL/min/kg or less indicated mild to moderate impairment (class B, n=15); more than 10 mL/min/kg and 16 or less mL/min/kg, moderate to severe impairment (class C, n=31); and more than 6 mL/min/kg and 10 mL/min/kg or less, severe impairment (class D, n=8). An average La/VO 2 relationship was constructed for each functional class with the La and VO 2 data obtained from each individual at each exercise step. RESULTS: Parameter b was obtained in all normal subjects and in 46 of 54 patients with COPD. It averaged 2.66±0.47 and 4.49±1.72 in normal subjects and COPD patients, respectively (P<0.005). In 30 of 46 patients, parameter b was greater than the upper value obtained in the normal group. The rise in arterial lactate concentration during exercise became progressively greater with the worsening of functional status. CONCLUSIONS: Lactate kinetics are frequently abnormal in patients with moderate to severe COPD compared with age-matched normal subjects. Reduction in functional status from class B to D was associated with a progressively greater increase in arterial blood lactate during exercise." @default.
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- W2316973399 date "1997-01-01" @default.
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- W2316973399 title "Lactate Kinetics during Exercise in Chronic Obstructive Pulmonary Disease" @default.
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- W2316973399 doi "https://doi.org/10.1155/1997/158678" @default.
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