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- W2316980028 abstract "Evidence suggests that 15–30% of individuals with obstructive sleep apnoea (OSA) have type 2 diabetes mellitus (T2DM), and that OSA is an independent risk factor for T2DM. There is considerable interest in ascertaining whether OSA treatment improves glycaemic control and insulin sensitivity in patients with OSA and T2DM. To assess the effects of continuous positive airway pressure (CPAP) therapy on glycosylated haemoglobin (HbA1c) level, insulin sensitivity and body mass index (BMI) in patients with OSA and T2DM. MEDLINE, EMBASE and the Cochrane Library were searched to identify prospective studies involving patients with OSA and T2DM who had received CPAP, and data on primary outcome (change in HbA1c) and/or secondary outcomes (changes in insulin sensitivity and BMI) were reported. All relevant studies published before 31 January 2014 were included. Six studies were included in the systematic review and meta-analysis. The numbers of patients ranged from 9 to 44 (total=128), and mean age ranged from 50.7 to 66.1 years. For the change in HbA1c (six studies, 128 patients), the combined standardised paired difference revealed no significant effect of CPAP (−0.071, 95% confidence interval (CI)=−0.245, 0.103; P=0.421). Similarly, there was no significant effect of CPAP on the change in BMI (−0.102, 95% CI=−0.296, 0.092; P=0.302; five studies, 103 patients). In contrast, there was a significant effect of CPAP on the change (improvement) in insulin sensitivity (0.330, 95% CI=0.001, 0.658; P=0.049; three studies, 39 patients). The limited available evidence from randomised controlled trials and prospective observational studies suggests that CPAP does not decrease HbA1c level or BMI in patients with OSA and T2DM but may improve insulin sensitivity. Treating obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) may improve insulin sensitivity. Up to 30% of patients with OSA, a condition in which breathing is interrupted due to throat narrowing during sleep, also suffer from type 2 diabetes mellitus (T2DM). Ye Feng from the Zhejiang University School of Medicine in China and colleagues systematically reviewed six studies examining the effects of CPAP treatment for OSA on indicators of T2DM. Following CPAP treatment for up to 4 months, no significant changes in blood sugar levels or body weight were noted. However, the research team found a significant improvement in insulin sensitivity. These findings raise the possibility that the application of mild air pressure to keep the airways open during the night could be used to treat both OSA and T2DM." @default.
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- W2316980028 date "2015-02-26" @default.
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- W2316980028 title "Effects of continuous positive airway pressure therapy on glycaemic control, insulin sensitivity and body mass index in patients with obstructive sleep apnoea and type 2 diabetes: a systematic review and meta-analysis" @default.
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- W2316980028 doi "https://doi.org/10.1038/npjpcrm.2015.5" @default.
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