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- W2316994756 abstract "Mesenchymal stem cells (MSCs) - cells are pluripotent, residents of bone marrow stroma. MSCs сould be isolated from the bone marrow and in vitro could demonstrate a significant proliferative capacity. Recovery of nerve tissue and stimulation of angiognesis of the central nervous system (CNS) by MSC – is a modern, forward-looking method of treating patients in a prolonged unconsciousness state. Aim: To evaluate safety and efficacy of autologous mesenchymal stem (AMSK) bone marrow stromal cells in patients in extended unconscious state after traumatic brain injury. Materials and methods: a randomized study included 30 patients in unconscious state for more than 4 weeks after traumatic brain injury. 15 patients formed a control group, receiving standard therapy and 15 patients - experimental group, in which on a background of standard therapy we performed intravenous transplantation AMSK. Results: we did not observe any complications associated with the study within 6 months after AMSK transfusion in patients of experimental group. Within 12 months after injury, there was a good disease outcome (4–5 points on the Glasgow scale) in 5 patients in the control group and 4 patients of the experimental group. However, patients of the experimental group, regained consciousness, indicated a more rapid and better recovery of cognitive and motor function, compared with similar patients of the control group. A small number of patients and short time of observation does not allow us yet to make conclusions about the direct effect of AMSK on the recovery of consciousness, but neuroprotection and restoring of CNS probably occur more actively after the AMSK transplantation. Discussion: Our results of AMSK transplantation in patients with prolonged unconsciousness state after head injury can demonstrate the feasibility of using MSCs in the complex treatment of patients with severe CNS lesions. We have clearly marked such effects as stimulation of angiogenesis in the damaged areas of CNS, eliminating the defitiensy of macroergs in the CNS. All this showed the need for further research of stem cell transplantation in patients with severe damage to the CNS." @default.
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- W2316994756 date "2012-02-01" @default.
- W2316994756 modified "2023-10-18" @default.
- W2316994756 title "A65 The Studies of Autologous Stem Cells in Patients with a Prolonged Unconscious State after Traumatic Brain Injury" @default.
- W2316994756 doi "https://doi.org/10.1097/01.eja.0000412511.65997.f2" @default.
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