FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2317002885> ?p ?o ?g. }

• W2317002885 endingPage "235" @default.
• W2317002885 startingPage "224" @default.
• W2317002885 abstract "Objective The diagnosis of acute coronary syndrome remains challenging especially in patients without clear symptoms or electrocardiographic and/or biomarker features. A hallmark of ischemia/reperfusion is activation of endothelial cells leading to altered expression of molecular markers, including selectins. In this context, we aimed to validate the value of ultrasound molecular imaging for detecting transient myocardial ischemia by using a clinically translatable dual P- and E-selectin–targeted ultrasound contrast agent (UCA) and microbubble (MBselectin). Material and Methods Transient (20 minutes) myocardial ischemia of rat heart was produced by ligation of the left anterior descending coronary artery ligation followed by 2-, 5-, or 24-hour reperfusion. Imaging of the transient ischemic event was achieved by the use of MBselectin. Performance of this clinically translatable targeted UCA was compared with that of antibody-targeted streptavidin MBs. Finally, immunohistochemistry staining of rat myocardial ischemic tissue was performed to assess expression of selectins accessible to targeted UCA. Results In rats subjected to myocardial ischemia (20 minutes) followed by reperfusion (2 hours), injection of MBselectin produced high late phase (ie, 10-minute postinjection) ultrasound molecular imaging enhancement in the myocardium, which colocalized with the ischemic area. Late phase enhancement persisted 5 and 24 hours after reperfusion. Similarly, the use of MBP and MBE, comprising antibodies specific for P- and E-selectin, respectively, showed high late-phase enhancement within the ischemic area compared with remote myocardial tissue. Two and 5 hours after ischemia has resolved, a persistent expression of these 2 selectins was detected. After 24 hours of reperfusion, only MBE produced late phase enhancement within the ischemic myocardium. Immunohistochemical findings revealed that both P- and E-selectin were expressed and accessible on the surface of the activated endothelium 2 and 5 hours after the acute ischemic event, whereas only E-selectin remained accessible after 24 hours. Conclusions Ultrasound molecular imaging of transient myocardial ischemia using dual selectin-targeted UCA is able to monitor the time course of expression of selectins after resolution of the ischemic event, paving the way for a large clinical diagnostic window." @default.
• W2317002885 created "2016-06-24" @default.
• W2317002885 creator A5008092046 @default.
• W2317002885 creator A5012088906 @default.
• W2317002885 creator A5027684620 @default.
• W2317002885 creator A5042925758 @default.
• W2317002885 creator A5047836897 @default.
• W2317002885 creator A5072909346 @default.
• W2317002885 creator A5073425039 @default.
• W2317002885 creator A5073992827 @default.
• W2317002885 creator A5081701161 @default.
• W2317002885 creator A5087110729 @default.
• W2317002885 creator A5088081135 @default.
• W2317002885 creator A5088575667 @default.
• W2317002885 creator A5090290241 @default.
• W2317002885 date "2014-04-01" @default.
• W2317002885 modified "2023-10-14" @default.
• W2317002885 title "Ultrasound Molecular Imaging of Transient Acute Myocardial Ischemia With a Clinically Translatable P- and E-Selectin Targeted Contrast Agent" @default.
• W2317002885 cites W1496351287 @default.
• W2317002885 cites W1512569924 @default.
• W2317002885 cites W1967525067 @default.
• W2317002885 cites W1980205263 @default.
• W2317002885 cites W1984619456 @default.
• W2317002885 cites W1987500112 @default.
• W2317002885 cites W1989308172 @default.
• W2317002885 cites W1990314722 @default.
• W2317002885 cites W1991085088 @default.
• W2317002885 cites W1992673857 @default.
• W2317002885 cites W1994033703 @default.
• W2317002885 cites W1995826822 @default.
• W2317002885 cites W1996694523 @default.
• W2317002885 cites W1999063996 @default.
• W2317002885 cites W2006926663 @default.
• W2317002885 cites W2009555874 @default.
• W2317002885 cites W2012485065 @default.
• W2317002885 cites W2015269201 @default.
• W2317002885 cites W2015531285 @default.
• W2317002885 cites W2023856777 @default.
• W2317002885 cites W2024697030 @default.
• W2317002885 cites W2035797488 @default.
• W2317002885 cites W2050856345 @default.
• W2317002885 cites W2052227572 @default.
• W2317002885 cites W2053084187 @default.
• W2317002885 cites W2061986418 @default.
• W2317002885 cites W2071666577 @default.
• W2317002885 cites W2092928993 @default.
• W2317002885 cites W2100303262 @default.
• W2317002885 cites W2109081751 @default.
• W2317002885 cites W2117127822 @default.
• W2317002885 cites W2120344766 @default.
• W2317002885 cites W2125542444 @default.
• W2317002885 cites W2130421963 @default.
• W2317002885 cites W2145902235 @default.
• W2317002885 cites W2149809268 @default.
• W2317002885 cites W2159527439 @default.
• W2317002885 cites W2161621220 @default.
• W2317002885 cites W2166256883 @default.
• W2317002885 cites W2169735148 @default.
• W2317002885 cites W2262294238 @default.
• W2317002885 cites W2329673071 @default.
• W2317002885 cites W2330886575 @default.
• W2317002885 cites W2335377152 @default.
• W2317002885 cites W2760092279 @default.
• W2317002885 cites W3030817736 @default.
• W2317002885 cites W3242620 @default.
• W2317002885 cites W4292022394 @default.
• W2317002885 doi "https://doi.org/10.1097/rli.0000000000000018" @default.
• W2317002885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24442162" @default.
• W2317002885 hasPublicationYear "2014" @default.
• W2317002885 type Work @default.
• W2317002885 sameAs 2317002885 @default.
• W2317002885 citedByCount "25" @default.
• W2317002885 countsByYear W23170028852014 @default.
• W2317002885 countsByYear W23170028852015 @default.
• W2317002885 countsByYear W23170028852016 @default.
• W2317002885 countsByYear W23170028852017 @default.
• W2317002885 countsByYear W23170028852018 @default.
• W2317002885 countsByYear W23170028852019 @default.
• W2317002885 countsByYear W23170028852020 @default.
• W2317002885 crossrefType "journal-article" @default.
• W2317002885 hasAuthorship W2317002885A5008092046 @default.
• W2317002885 hasAuthorship W2317002885A5012088906 @default.
• W2317002885 hasAuthorship W2317002885A5027684620 @default.
• W2317002885 hasAuthorship W2317002885A5042925758 @default.
• W2317002885 hasAuthorship W2317002885A5047836897 @default.
• W2317002885 hasAuthorship W2317002885A5072909346 @default.
• W2317002885 hasAuthorship W2317002885A5073425039 @default.
• W2317002885 hasAuthorship W2317002885A5073992827 @default.
• W2317002885 hasAuthorship W2317002885A5081701161 @default.
• W2317002885 hasAuthorship W2317002885A5087110729 @default.
• W2317002885 hasAuthorship W2317002885A5088081135 @default.
• W2317002885 hasAuthorship W2317002885A5088575667 @default.
• W2317002885 hasAuthorship W2317002885A5090290241 @default.
• W2317002885 hasConcept C126322002 @default.
• W2317002885 hasConcept C126838900 @default.
• W2317002885 hasConcept C142724271 @default.
• W2317002885 hasConcept C143753070 @default.
• W2317002885 hasConcept C151730666 @default.

• next